SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		4 / 4 VAL A  93
LEU A 152
ILE A 133
LEU A 109
 None
 0.98A 2byoA-4gelA:
undetectable		 2byoA-4gelA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		5 / 12 SER A 122
LEU A 212
VAL A 205
VAL A  93
PHE A 114
 None
 1.17A 3u9fB-4gelA:
undetectable
3u9fC-4gelA:
undetectable		 3u9fB-4gelA:
19.03
3u9fC-4gelA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		5 / 12 SER A 122
LEU A 212
VAL A 205
VAL A  93
PHE A 114
 None
 1.14A 3u9fH-4gelA:
undetectable
3u9fI-4gelA:
undetectable		 3u9fH-4gelA:
19.03
3u9fI-4gelA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		5 / 11 SER A 122
LEU A 212
VAL A 205
VAL A  93
PHE A 114
 None
 1.16A 3u9fN-4gelA:
undetectable
3u9fO-4gelA:
undetectable		 3u9fN-4gelA:
19.03
3u9fO-4gelA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		5 / 12 PHE A 114
SER A 122
LEU A 212
VAL A 205
VAL A  93
 None
 1.01A 3u9fP-4gelA:
undetectable
3u9fS-4gelA:
undetectable		 3u9fP-4gelA:
19.03
3u9fS-4gelA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		4 / 7 ARG A 102
ALA A 223
THR A 228
ILE A 174
 None
 0.77A 5te8A-4gelA:
undetectable		 5te8A-4gelA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Drosophila
melanogaster) 		4 / 5 GLN A  99
ARG A 102
TYR A 197
GLU A  52
 None
 1.19A 5yf0A-4gelA:
undetectable		 5yf0A-4gelA:
18.98