SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4geq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4geq KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 213
ILE A 171
PHE A 163
LEU B 164
LEU A 200
 None
 1.13A 1dtlA-4geqA:
undetectable		 1dtlA-4geqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 4geq KINETOCHORE PROTEIN
SPC24
KINETOCHORE PROTEIN
SPC25
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 210
TYR B 165
GLY B 169
LEU A 206
 None
 0.97A 1s1xA-4geqA:
undetectable		 1s1xA-4geqA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4geq KINETOCHORE PROTEIN
SPC25
KINETOCHORE PROTEIN
SPC24
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 LYS B 185
ARG B 183
ASP A 215
 None
None
GOL  B 301 (-3.3A)
 1.09A 3o7wA-4geqB:
undetectable		 3o7wA-4geqB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4geq KINETOCHORE PROTEIN
SPC25
KINETOCHORE PROTEIN
SPC24
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP A 205
TRP B 208
SER B 167
 None
 0.83A 4lrhB-4geqA:
undetectable		 4lrhB-4geqA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4geq KINETOCHORE PROTEIN
SPC25
KINETOCHORE PROTEIN
SPC24
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP A 205
TRP B 208
SER B 167
 None
 0.81A 4lrhF-4geqA:
undetectable		 4lrhF-4geqA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4geq KINETOCHORE PROTEIN
SPC25
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 181
LEU A 196
LEU A 217
PHE A 163
 None
 0.72A 4qopC-4geqA:
undetectable		 4qopC-4geqA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 4geq KINETOCHORE PROTEIN
SPC25
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 210
ALA A 213
LEU A 196
LEU A 200
LEU A 217
 None
 1.15A 4zn7A-4geqA:
undetectable		 4zn7A-4geqA:
19.48