SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 9 VAL A 197
GLY A 219
ILE A 221
PHE A 267
ILE A 153
 None
 1.16A 1cetA-4gewA:
undetectable		 1cetA-4gewA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 LEU A 154
PRO A 350
SER A 351
MET A 139
 None
 1.18A 2qd2A-4gewA:
undetectable		 2qd2A-4gewA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 8 ASP A 271
SER A 235
HIS A 232
ASP A 322
 GOL  A 401 (-2.6A)
GOL  A 401 (-2.4A)
GOL  A 401 (-3.7A)
None
 1.12A 3sg9B-4gewA:
undetectable		 3sg9B-4gewA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 228
LEU A 190
ILE A 189
ALA A 188
ILE A 356
 None
 0.87A 3vrmA-4gewA:
undetectable		 3vrmA-4gewA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		3 / 3 ARG A 342
PHE A 349
PRO A 350
 None
 0.42A 3zoaB-4gewA:
undetectable		 3zoaB-4gewA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 11 ALA A 362
LEU A 115
GLY A 263
ILE A 221
GLY A 328
 GOL  A 408 ( 4.2A)
GOL  A 408 (-3.9A)
None
None
GOL  A 403 (-4.0A)
 1.06A 3zosA-4gewA:
undetectable
3zosB-4gewA:
undetectable		 3zosA-4gewA:
21.39
3zosB-4gewA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 5 VAL A 146
LEU A 154
LEU A 190
ILE A 127
 None
 0.94A 4a9jA-4gewA:
undetectable		 4a9jA-4gewA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 7 LEU A 154
PRO A 350
SER A 351
MET A 139
 None
 1.23A 4klrA-4gewA:
undetectable		 4klrA-4gewA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 PHE A 267
LEU A 228
GLY A 222
ALA A 264
VAL A 122
 None
 0.98A 4wnwB-4gewA:
undetectable		 4wnwB-4gewA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 7 VAL A 122
ILE A 189
ASN A 261
PHE A 267
 None
 0.72A 5hieC-4gewA:
undetectable		 5hieC-4gewA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 VAL A 226
VAL A 122
LEU A 272
GLY A 269
LEU A 228
 None
 1.08A 5iktA-4gewA:
undetectable		 5iktA-4gewA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 VAL A 226
VAL A 122
LEU A 272
GLY A 269
LEU A 228
 None
 1.06A 5iktB-4gewA:
undetectable		 5iktB-4gewA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 12 GLN A 157
GLN A 215
HIS A 200
LEU A 156
ILE A 176
 None
None
GOL  A 406 (-4.2A)
None
GOL  A 402 ( 4.8A)
 1.05A 5uacC-4gewA:
undetectable		 5uacC-4gewA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		3 / 3 LYS A 181
LEU A 190
ASP A 168
 None
 0.83A 5zv2A-4gewA:
undetectable		 5zv2A-4gewA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		5 / 10 VAL A 266
GLU A 256
MET A 251
LEU A 214
ILE A 216
 None
 1.50A 6d9hR-4gewA:
undetectable		 6d9hR-4gewA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE
(Caenorhabditis
elegans) 		4 / 6 GLN A 215
PHE A 155
LEU A 272
PHE A 247
 None
 1.23A 6nmpC-4gewA:
undetectable
6nmpJ-4gewA:
undetectable		 6nmpC-4gewA:
19.83
6nmpJ-4gewA:
10.21