SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  10
ALA A  15
SER A  13
HIS A 106
LEU A 101
 None
None
None
GSH  A 302 (-4.3A)
None
 1.02A 1kiaD-4gf0A:
undetectable		 1kiaD-4gf0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 LEU A  58
LEU A   3
VAL A  16
ALA A  78
ALA A  23
 None
 1.17A 1n5xA-4gf0A:
undetectable		 1n5xA-4gf0A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 LEU A  58
LEU A   3
VAL A  16
ALA A  78
ALA A  23
 None
 1.17A 1n5xB-4gf0A:
undetectable		 1n5xB-4gf0A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 GLY A  10
ALA A  15
SER A  13
HIS A 106
LEU A 101
 None
None
None
GSH  A 302 (-4.3A)
None
 0.99A 1nbhB-4gf0A:
undetectable		 1nbhB-4gf0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 7 PHE A 166
LEU A  83
PHE A 188
MET A 192
 None
 1.04A 1wrlE-4gf0A:
undetectable		 1wrlE-4gf0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 8 LYS A 112
ASN A 170
PRO A 163
PHE A 158
 None
 1.33A 3bjwD-4gf0A:
undetectable		 3bjwD-4gf0A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 9 LEU A   5
PRO A  54
LEU A  56
THR A  67
LEU A  71
 None
GSH  A 302 (-4.4A)
None
GSH  A 302 (-4.0A)
None
 1.24A 3q1eB-4gf0A:
undetectable
3q1eD-4gf0A:
undetectable		 3q1eB-4gf0A:
20.40
3q1eD-4gf0A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		5 / 12 VAL A 143
ALA A  97
THR A  89
GLY A 155
LEU A 154
 None
None
None
CL  A 301 ( 3.9A)
None
 1.21A 5m54E-4gf0A:
undetectable		 5m54E-4gf0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 4 THR A  62
ASP A  61
ARG A  57
LEU A  58
 None
 0.97A 5tdmA-4gf0A:
undetectable		 5tdmA-4gf0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 4gf0 GLUTATHIONE
S-TRANSFERASE
(Sulfitobacter
sp.
NAS-14.1) 		4 / 6 THR A  62
ASP A  61
ARG A  57
LEU A  58
 None
 0.88A 5tdzA-4gf0A:
undetectable		 5tdzA-4gf0A:
20.59