SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		5 / 11 VAL A 593
ASN A 589
GLU A 588
LEU A 564
ILE A 546
 None
 1.26A 1t6zA-4gf2A:
undetectable		 1t6zA-4gf2A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		5 / 10 LEU A 405
PHE A 327
ILE A 320
LEU A 376
LEU A 396
 None
 0.86A 1yi4A-4gf2A:
undetectable		 1yi4A-4gf2A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 7 GLY A 455
PHE A 454
ASP A 450
THR A 424
 None
GOL  A 807 (-3.4A)
None
GOL  A 807 ( 4.3A)
 1.17A 2aouB-4gf2A:
undetectable		 2aouB-4gf2A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 8 ARG A 485
GLN A 618
ARG A 582
THR A 493
 None
 1.34A 2vxaF-4gf2A:
undetectable
2vxaG-4gf2A:
undetectable
2vxaI-4gf2A:
undetectable		 2vxaF-4gf2A:
7.63
2vxaG-4gf2A:
7.63
2vxaI-4gf2A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 8 TYR A 556
GLN A 618
GLU A 625
GLU A 481
 None
 1.31A 3dh0A-4gf2A:
undetectable		 3dh0A-4gf2A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 7 TYR A 504
GLU A 562
LEU A 508
TRP A 585
 None
 1.00A 3k8mA-4gf2A:
undetectable		 3k8mA-4gf2A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 7 TYR A 504
GLU A 562
LEU A 508
TRP A 585
 None
 1.08A 3k8mB-4gf2A:
undetectable		 3k8mB-4gf2A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 8 GLU A 561
LYS A 559
ASN A 563
ASN A 565
 None
None
None
GOL  A 812 ( 4.1A)
 1.32A 3kp6A-4gf2A:
undetectable
3kp6B-4gf2A:
0.2		 3kp6A-4gf2A:
13.88
3kp6B-4gf2A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 5 LYS A 637
ILE A 669
PHE A 630
ASP A 629
 None
 1.17A 3kp6A-4gf2A:
undetectable
3kp6B-4gf2A:
0.2		 3kp6A-4gf2A:
13.88
3kp6B-4gf2A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 5 GLU A 506
ASP A 450
ASP A 416
ASN A 345
 GOL  A 813 ( 4.5A)
None
None
None
 1.39A 3vywD-4gf2A:
undetectable		 3vywD-4gf2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 5 TYR A 665
LEU A 671
ASP A 629
VAL A 680
 None
 1.27A 4nkvA-4gf2A:
undetectable		 4nkvA-4gf2A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		3 / 3 THR A 209
MET A 294
HIS A 293
 None
None
GOL  A 814 (-3.2A)
 0.92A 5uunA-4gf2A:
2.4		 5uunA-4gf2A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4gf2 ERYTHROCYTE BINDING
ANTIGEN 140
(Plasmodium
falciparum) 		4 / 6 PHE A 476
PRO A 477
GLY A 478
THR A 479
 None
 0.52A 5x24A-4gf2A:
undetectable		 5x24A-4gf2A:
21.33