SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 10 VAL A 404
ILE A 480
ILE A 381
LEU A 354
PHE A 268
 None
 1.13A 1z11C-4gf8A:
undetectable		 1z11C-4gf8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 10 VAL A 404
ILE A 480
ILE A 381
LEU A 354
PHE A 268
 None
 1.07A 1z11D-4gf8A:
undetectable		 1z11D-4gf8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		3 / 3 ARG A 120
ASP A  60
ASP A 458
 None
 0.82A 2ejtA-4gf8A:
undetectable		 2ejtA-4gf8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 8 THR A 407
VAL A 404
ASN A 251
ALA A 396
 None
 1.16A 2ij7C-4gf8A:
undetectable		 2ij7C-4gf8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 9 ILE A 281
PHE A 248
ALA A 247
VAL A 482
 None
 0.87A 2vufA-4gf8A:
undetectable		 2vufA-4gf8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 6 ASP A 283
ILE A 284
LEU A 371
TYR A 321
 None
 0.99A 2ya7B-4gf8A:
undetectable		 2ya7B-4gf8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 6 ASP A 283
ILE A 284
GLN A 375
TYR A 321
 None
 1.37A 2ya7C-4gf8A:
undetectable		 2ya7C-4gf8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 6 ASP A 283
ILE A 284
LEU A 371
TYR A 321
 None
 0.99A 2ya7D-4gf8A:
undetectable		 2ya7D-4gf8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 12 LEU A 376
LEU A 329
ILE A 381
VAL A 250
VAL A 404
 None
 1.02A 2ygpA-4gf8A:
undetectable		 2ygpA-4gf8A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 12 VAL A 250
ILE A 480
TYR A 409
TYR A 418
TYR A 423
 None
 1.39A 3hgiA-4gf8A:
undetectable		 3hgiA-4gf8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 PRO A 415
ILE A 469
LEU A 446
TYR A 418
 None
 0.84A 3p50A-4gf8A:
undetectable		 3p50A-4gf8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 PRO A 415
ILE A 469
LEU A 446
TYR A 418
 None
 0.84A 3p50B-4gf8A:
undetectable		 3p50B-4gf8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 PRO A 415
ILE A 469
LEU A 446
TYR A 418
 None
 0.84A 3p50C-4gf8A:
undetectable		 3p50C-4gf8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 PRO A 415
ILE A 469
LEU A 446
TYR A 418
 None
 0.84A 3p50D-4gf8A:
undetectable		 3p50D-4gf8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 PRO A 415
ILE A 469
LEU A 446
TYR A 418
 None
 0.84A 3p50E-4gf8A:
undetectable		 3p50E-4gf8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 12 THR A 245
ASN A 293
ALA A 413
GLY A 412
ASN A  46
 None
 1.17A 3v3oA-4gf8A:
undetectable		 3v3oA-4gf8A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 5 LEU A 276
ARG A 278
PRO A 481
ALA A 247
 None
 1.20A 3vm4A-4gf8A:
undetectable		 3vm4A-4gf8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 TRP A 107
PHE A  90
GLU A 133
VAL A 130
 None
 1.48A 4cwxA-4gf8A:
undetectable
4cwxB-4gf8A:
undetectable		 4cwxA-4gf8A:
22.58
4cwxB-4gf8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 VAL A 130
TRP A 107
PHE A  90
GLU A 133
 None
 1.47A 4cwyA-4gf8A:
undetectable
4cwyB-4gf8A:
undetectable		 4cwyA-4gf8A:
22.58
4cwyB-4gf8A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 11 LEU A 123
VAL A 130
PHE A  90
PHE A  67
PHE A 121
 None
 1.46A 4evrA-4gf8A:
undetectable		 4evrA-4gf8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 12 GLY A 412
TYR A 409
ALA A 413
ASN A  46
TYR A 132
 None
 1.35A 4ymgA-4gf8A:
undetectable		 4ymgA-4gf8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		5 / 12 GLY A 412
TYR A 409
ALA A 413
ASN A  46
TYR A 132
 None
 1.32A 4ymgB-4gf8A:
undetectable		 4ymgB-4gf8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 TRP A 107
PHE A  90
GLU A 133
VAL A 130
 None
 1.45A 5vvdA-4gf8A:
undetectable
5vvdB-4gf8A:
undetectable		 5vvdA-4gf8A:
21.85
5vvdB-4gf8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 6 VAL A 522
TYR A 184
GLU A  35
ARG A  51
 None
 1.01A 5z3jA-4gf8A:
undetectable		 5z3jA-4gf8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 TRP A 107
PHE A  90
GLU A 133
VAL A 130
 None
 1.50A 6av6A-4gf8A:
undetectable
6av6B-4gf8A:
0.0		 6av6A-4gf8A:
10.10
6av6B-4gf8A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 7 ASN A  46
ASN A  41
GLU A 517
ARG A 508
 None
 1.03A 6b8kA-4gf8A:
undetectable		 6b8kA-4gf8A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN
(Vibrio
cholerae) 		4 / 8 ASN A  46
ASN A  41
GLU A 517
ARG A 508
 None
 1.12A 6b94A-4gf8A:
undetectable		 6b94A-4gf8A:
9.45