SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 9 ASN A  70
ILE A 104
PRO A 105
ILE A 120
THR A 195
 ANP  A1202 ( 2.7A)
None
None
ANP  A1202 (-3.8A)
ANP  A1202 (-3.4A)
 0.81A 1aj6A-4gfhA:
16.3		 1aj6A-4gfhA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.14A 1dhfA-4gfhA:
undetectable		 1dhfA-4gfhA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  51
LEU A 255
ALA A 293
THR A 278
 None
 0.80A 1ie4B-4gfhA:
undetectable
1ie4D-4gfhA:
undetectable		 1ie4B-4gfhA:
7.57
1ie4D-4gfhA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  73
ILE A 104
PRO A 105
ILE A 120
THR A 195
 None
None
None
ANP  A1202 (-3.8A)
ANP  A1202 (-3.4A)
 0.83A 1kijA-4gfhA:
28.0		 1kijA-4gfhA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  70
ILE A 104
PRO A 105
ILE A 120
THR A 195
 ANP  A1202 ( 2.7A)
None
None
ANP  A1202 (-3.8A)
ANP  A1202 (-3.4A)
 0.82A 1kijB-4gfhA:
28.5		 1kijB-4gfhA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 493
ARG A 475
GLN A 496
GLU A 494
 None
 0.97A 1lqtB-4gfhA:
undetectable		 1lqtB-4gfhA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 493
ARG A 475
GLN A 496
GLU A 494
 None
 0.97A 1lquB-4gfhA:
undetectable		 1lquB-4gfhA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 869
TYR A 840
PRO A 843
 None
 0.84A 1mcnA-4gfhA:
2.4
1mcnB-4gfhA:
undetectable
1mcnP-4gfhA:
undetectable		 1mcnA-4gfhA:
11.34
1mcnB-4gfhA:
11.34
1mcnP-4gfhA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 558
LEU A 624
HIS A 520
PHE A 627
GLY A 554
 None
 1.16A 1mjlA-4gfhA:
undetectable
1mjlB-4gfhA:
undetectable		 1mjlA-4gfhA:
6.52
1mjlB-4gfhA:
6.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		7 / 7 HIS A  20
THR A  27
TYR A  28
ASN A 142
TYR A 144
LEU A 148
GLN A 365
 None
None
None
ANP  A1202 (-4.6A)
None
None
ANP  A1202 (-3.0A)
 0.34A 1qzrA-4gfhA:
60.9		 1qzrA-4gfhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		7 / 7 HIS A  20
THR A  27
TYR A  28
ASN A 142
TYR A 144
LEU A 148
GLN A 365
 None
None
None
ANP  A1202 (-4.6A)
None
None
ANP  A1202 (-3.0A)
 0.41A 1qzrB-4gfhA:
59.7		 1qzrB-4gfhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_B_ADNB501_1
(HYPOTHETICAL PROTEIN
PH0463)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 634
HIS A 628
ILE A 672
ASP A 674
PRO A 671
 None
 1.44A 1wu8B-4gfhA:
1.6
1wu8C-4gfhA:
1.5		 1wu8B-4gfhA:
12.35
1wu8C-4gfhA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 304
ARG A 287
ASN A 306
 None
 0.92A 1xzxX-4gfhA:
1.3		 1xzxX-4gfhA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 459
ASP A 526
TYR A 602
LYS A 607
 None
 1.26A 2dpzA-4gfhA:
undetectable		 2dpzA-4gfhA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 357
ASP A 376
PHE A 377
THR A 371
THR A 315
 None
 1.49A 2dttE-4gfhA:
undetectable
2dttF-4gfhA:
undetectable		 2dttE-4gfhA:
7.71
2dttF-4gfhA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 621
LEU A 624
LYS A 625
MET A 522
 None
 1.39A 2gj5A-4gfhA:
undetectable		 2gj5A-4gfhA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.20A 2obvA-4gfhA:
undetectable		 2obvA-4gfhA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.16A 2p02A-4gfhA:
undetectable		 2p02A-4gfhA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.02A 2w3aB-4gfhA:
undetectable		 2w3aB-4gfhA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.07A 2w3mA-4gfhA:
undetectable		 2w3mA-4gfhA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 435
LEU A 445
ASP A 431
LEU A 429
ILE A 423
 None
 0.87A 2w9sA-4gfhA:
undetectable		 2w9sA-4gfhA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 435
LEU A 445
ASP A 431
LEU A 429
ILE A 423
 None
 0.92A 2w9sB-4gfhA:
undetectable		 2w9sB-4gfhA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 148
PHE A 152
LEU A  22
ASP A  26
 None
 1.14A 2wm3A-4gfhA:
undetectable		 2wm3A-4gfhA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 194
VAL A 170
TYR A 188
ILE A 106
 None
 1.20A 2xz5B-4gfhA:
undetectable
2xz5E-4gfhA:
undetectable		 2xz5B-4gfhA:
10.54
2xz5E-4gfhA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.22A 2xz5A-4gfhA:
undetectable
2xz5C-4gfhA:
undetectable		 2xz5A-4gfhA:
10.54
2xz5C-4gfhA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.23A 2xz5C-4gfhA:
undetectable
2xz5D-4gfhA:
undetectable		 2xz5C-4gfhA:
10.54
2xz5D-4gfhA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.21A 2xz5D-4gfhA:
undetectable
2xz5E-4gfhA:
undetectable		 2xz5D-4gfhA:
10.54
2xz5E-4gfhA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 308
PRO A 360
VAL A 325
PHE A 377
 None
 1.15A 2ygnA-4gfhA:
undetectable		 2ygnA-4gfhA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 139
ILE A  67
CYH A 149
PHE A 152
GLY A 143
 None
None
None
None
ANP  A1202 (-3.1A)
 1.18A 3ko0A-4gfhA:
undetectable
3ko0C-4gfhA:
undetectable		 3ko0A-4gfhA:
5.97
3ko0C-4gfhA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 143
GLY A 139
ILE A  67
CYH A 149
PHE A 152
 ANP  A1202 (-3.1A)
None
None
None
None
 1.21A 3ko0F-4gfhA:
undetectable
3ko0G-4gfhA:
0.0		 3ko0F-4gfhA:
5.97
3ko0G-4gfhA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 143
GLY A 139
ILE A  67
CYH A 149
PHE A 152
 ANP  A1202 (-3.1A)
None
None
None
None
 1.17A 3ko0L-4gfhA:
undetectable
3ko0N-4gfhA:
undetectable		 3ko0L-4gfhA:
5.97
3ko0N-4gfhA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 139
ILE A  67
CYH A 149
PHE A 152
GLY A 143
 None
None
None
None
ANP  A1202 (-3.1A)
 1.19A 3ko0R-4gfhA:
undetectable
3ko0T-4gfhA:
undetectable		 3ko0R-4gfhA:
5.97
3ko0T-4gfhA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 617
PHE A 559
GLY A 460
ALA A 457
THR A 448
 None
 1.15A 3ld6A-4gfhA:
undetectable		 3ld6A-4gfhA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 617
PHE A 559
GLY A 460
ALA A 457
THR A 448
 None
 1.17A 3ld6B-4gfhA:
undetectable		 3ld6B-4gfhA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.13A 3n0hA-4gfhA:
undetectable		 3n0hA-4gfhA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 495
ILE A 498
VAL A 481
ILE A 538
 None
 0.69A 3p4wC-4gfhA:
undetectable		 3p4wC-4gfhA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 171
TYR A 169
GLN A 167
ILE A 106
 None
 0.92A 3peoG-4gfhA:
undetectable		 3peoG-4gfhA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 449
ILE A 534
SER A 532
GLU A 679
GLU A 558
 None
 1.17A 3r75A-4gfhA:
undetectable		 3r75A-4gfhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 449
ILE A 534
SER A 532
GLU A 679
GLU A 558
 None
 1.16A 3r75B-4gfhA:
undetectable		 3r75B-4gfhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 449
ILE A 534
SER A 532
GLU A 679
GLU A 558
 None
 1.17A 3r76A-4gfhA:
2.4		 3r76A-4gfhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 449
ILE A 534
SER A 532
GLU A 679
GLU A 558
 None
 1.19A 3r76B-4gfhA:
undetectable		 3r76B-4gfhA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.15A 3s3vA-4gfhA:
undetectable		 3s3vA-4gfhA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 882
ILE A 841
PRO A 842
PHE A 844
 None
 1.19A 3s3vA-4gfhA:
undetectable		 3s3vA-4gfhA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 316
SER A 379
ASN A 306
 None
 0.82A 3s8pB-4gfhA:
undetectable		 3s8pB-4gfhA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 466
GLY A 470
LEU A 447
MET A 524
ALA A 457
 None
 1.28A 3sxjA-4gfhA:
undetectable		 3sxjA-4gfhA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 466
GLY A 470
LEU A 447
MET A 524
ALA A 457
 None
 1.28A 3sxjB-4gfhA:
undetectable		 3sxjB-4gfhA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 542
ILE A 672
GLY A 536
ILE A 638
ILE A 534
 None
 1.37A 3uj7A-4gfhA:
undetectable		 3uj7A-4gfhA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 TYR A1005
TYR A 803
LEU A 696
TRP A 817
 None
 1.44A 3uzzB-4gfhA:
undetectable		 3uzzB-4gfhA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 639
ILE A 638
PHE A 642
GLY A 536
 None
 0.77A 4acbC-4gfhA:
undetectable		 4acbC-4gfhA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 738
GLY A 737
SER A 729
 None
 0.50A 4b53B-4gfhA:
undetectable		 4b53B-4gfhA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 194
VAL A 170
TYR A 188
ILE A 106
 None
 1.25A 4bqtC-4gfhA:
undetectable
4bqtD-4gfhA:
undetectable		 4bqtC-4gfhA:
10.54
4bqtD-4gfhA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 362
ASN A 142
GLY A 140
THR A 138
 None
ANP  A1202 (-4.6A)
ANP  A1202 (-2.9A)
None
 0.98A 4ejjB-4gfhA:
undetectable		 4ejjB-4gfhA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1008
HIS A 796
TYR A1005
 None
 0.90A 4fu8A-4gfhA:
undetectable		 4fu8A-4gfhA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1008
HIS A 796
TYR A1005
 None
 1.00A 4fu9A-4gfhA:
undetectable		 4fu9A-4gfhA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 954
ARG A 963
TRP A 929
 None
 1.27A 4i90A-4gfhA:
undetectable		 4i90A-4gfhA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 719
GLU A 786
LEU A 715
LYS A 713
 None
 1.34A 4k4yA-4gfhA:
undetectable		 4k4yA-4gfhA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 719
GLU A 786
LEU A 715
LYS A 713
 None
 1.35A 4k4yI-4gfhA:
undetectable		 4k4yI-4gfhA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.06A 4kebB-4gfhA:
undetectable		 4kebB-4gfhA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.19A 4kttC-4gfhA:
undetectable		 4kttC-4gfhA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.19A 4ndnC-4gfhA:
undetectable		 4ndnC-4gfhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 146
GLY A 145
ASP A  65
ILE A 120
GLY A 122
 ANP  A1202 (-3.5A)
ANP  A1202 (-3.2A)
None
ANP  A1202 (-3.8A)
None
 0.83A 4obwB-4gfhA:
undetectable		 4obwB-4gfhA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1158
HIS A 796
LYS A 793
 None
 0.93A 4qzuD-4gfhA:
undetectable		 4qzuD-4gfhA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 537
SER A 643
PHE A 642
GLY A 536
GLY A 531
 None
 0.93A 4rzvA-4gfhA:
undetectable		 4rzvA-4gfhA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 357
VAL A 305
PHE A 352
CYH A 381
 None
 1.21A 4rzvA-4gfhA:
undetectable		 4rzvA-4gfhA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 682
LEU A 663
VAL A 662
PHE A 675
 None
 1.10A 4uswA-4gfhA:
undetectable		 4uswA-4gfhA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 660
ILE A 523
PHE A 675
GLY A 536
THR A 661
 None
 1.19A 4zdyA-4gfhA:
1.0		 4zdyA-4gfhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 539
PHE A 627
ILE A 523
GLU A 558
 None
 1.34A 4zzcA-4gfhA:
3.5
4zzcB-4gfhA:
undetectable		 4zzcA-4gfhA:
14.75
4zzcB-4gfhA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.18A 5a1iA-4gfhA:
undetectable		 5a1iA-4gfhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.18A 5a1iA-4gfhA:
undetectable		 5a1iA-4gfhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 316
SER A 379
ASN A 306
 None
 0.78A 5cprB-4gfhA:
undetectable		 5cprB-4gfhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 504
GLY A 503
ARG A 517
TYR A 518
LEU A 549
 None
 1.36A 5czyA-4gfhA:
undetectable		 5czyA-4gfhA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 504
GLY A 503
TYR A 518
GLU A 494
LEU A 542
 None
 1.35A 5czyA-4gfhA:
undetectable		 5czyA-4gfhA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 623
VAL A 446
GLY A 460
ALA A 457
 None
 1.05A 5hwaA-4gfhA:
undetectable		 5hwaA-4gfhA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 760
ARG A 792
ILE A 794
PHE A 795
 None
 1.18A 5kirB-4gfhA:
undetectable		 5kirB-4gfhA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 GLN A1167
LEU A1170
ASP A1173
ALA A1176
 None
 0.88A 5nwvA-4gfhA:
undetectable		 5nwvA-4gfhA:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 708
GLN A 807
HIS A 735
TYR A 727
 None
 1.41A 5ov9B-4gfhA:
undetectable		 5ov9B-4gfhA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 538
LEU A 474
LEU A 454
ALA A 453
 None
 0.80A 5y7pE-4gfhA:
undetectable		 5y7pE-4gfhA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  86
VAL A  69
LEU A  68
PHE A 199
VAL A 197
 None
 1.30A 6dryA-4gfhA:
2.7		 6dryA-4gfhA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 660
ILE A 523
PHE A 675
GLY A 536
THR A 661
 None
 1.15A 6e8qA-4gfhA:
undetectable		 6e8qA-4gfhA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.18A 6fbnB-4gfhA:
undetectable		 6fbnB-4gfhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.21A 6fcdA-4gfhA:
undetectable		 6fcdA-4gfhA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 533
ASP A 530
SER A 740
ASP A 687
 None
 1.20A 6g6rA-4gfhA:
undetectable		 6g6rA-4gfhA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H3D_A_DHIA601_0
(DUF2338
DOMAIN-CONTAINING
PROTEIN)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 803
ASN A 694
ARG A 704
PHE A 795
 None
 1.44A 6h3dA-4gfhA:
undetectable		 6h3dA-4gfhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		 4gfh DNA TOPOISOMERASE 2
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 250
ASP A 225
ASN A 227
TYR A 254
GLU A  44
 None
 1.38A 6mb7A-4gfhA:
undetectable		 6mb7A-4gfhA:
5.02