SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ASP A 219
ARG A 151
TYR A 149
THR A  96
 None
 1.42A 1ceaA-4gfjA:
undetectable
1ceaB-4gfjA:
undetectable		 1ceaA-4gfjA:
8.05
1ceaB-4gfjA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 SER A 322
ASP A 320
GLU A 375
GLU A 215
 GOL  A 703 (-2.8A)
None
None
None
 0.94A 1knyA-4gfjA:
2.3
1knyB-4gfjA:
3.1		 1knyA-4gfjA:
17.23
1knyB-4gfjA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 GLU A 175
GLU A 171
LEU A 189
GLU A 186
 None
 1.12A 1linA-4gfjA:
undetectable		 1linA-4gfjA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.47A 1mskA-4gfjA:
undetectable		 1mskA-4gfjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_D_DESD128_1
(TRANSTHYRETIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 4 LYS A  28
LEU A 254
LEU A  62
SER A  65
 None
 1.46A 1tz8D-4gfjA:
undetectable		 1tz8D-4gfjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.97A 1v54N-4gfjA:
4.3
1v54W-4gfjA:
undetectable		 1v54N-4gfjA:
20.06
1v54W-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ARG A 112
SER A  99
TYR A 103
 None
 0.78A 1x70A-4gfjA:
undetectable		 1x70A-4gfjA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ALA A 366
ALA A 367
LEU A 356
ALA A 401
LEU A 343
 None
 1.06A 1xiuB-4gfjA:
undetectable		 1xiuB-4gfjA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		6 / 12 ILE A 380
ALA A 382
PHE A 374
ARG A 396
LEU A 397
ILE A 388
 None
 1.38A 2d0kB-4gfjA:
undetectable		 2d0kB-4gfjA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.97A 2dyrN-4gfjA:
1.2
2dyrW-4gfjA:
undetectable		 2dyrN-4gfjA:
20.06
2dyrW-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.95A 2eikN-4gfjA:
1.8
2eikW-4gfjA:
undetectable		 2eikN-4gfjA:
20.06
2eikW-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.93A 2eilN-4gfjA:
1.2
2eilW-4gfjA:
undetectable		 2eilN-4gfjA:
20.06
2eilW-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.91A 2einN-4gfjA:
4.1
2einW-4gfjA:
undetectable		 2einN-4gfjA:
20.06
2einW-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 ILE A 377
ARG A  90
ARG A  93
ILE A 388
 None
 1.06A 2q72A-4gfjA:
1.1		 2q72A-4gfjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 VAL A 106
THR A  96
ARG A 144
ILE A 145
SER A 227
 None
None
GOL  A 703 ( 4.5A)
None
None
 1.44A 2vdyA-4gfjA:
undetectable		 2vdyA-4gfjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 ARG A 231
ARG A 436
PRO A 220
 None
 0.98A 2wljA-4gfjA:
2.9		 2wljA-4gfjA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.96A 3ablA-4gfjA:
2.5
3ablJ-4gfjA:
undetectable		 3ablA-4gfjA:
20.06
3ablJ-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.90A 3ablN-4gfjA:
1.8
3ablW-4gfjA:
undetectable		 3ablN-4gfjA:
20.06
3ablW-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ILE A 114
ILE A 105
VAL A 147
GLY A 150
ARG A  76
 None
 0.99A 3em0B-4gfjA:
undetectable		 3em0B-4gfjA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 VAL A 232
PHE A 170
ILE A 174
ALA A 141
ILE A 188
 None
 1.08A 3me6A-4gfjA:
undetectable		 3me6A-4gfjA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ASP A 160
PRO A 163
GLN A  57
GLU A  54
 None
 1.11A 3oyaA-4gfjA:
undetectable		 3oyaA-4gfjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_B_STIB4_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 VAL A  27
ILE A 278
MET A  40
ARG A 112
 None
 1.26A 3pyyB-4gfjA:
undetectable		 3pyyB-4gfjA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 PHE A 374
TYR A 402
LEU A 353
 None
 0.64A 3sueB-4gfjA:
undetectable		 3sueB-4gfjA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 5 LEU A  24
PHE A  23
PRO A 126
ALA A 115
 None
 1.42A 3vm4A-4gfjA:
undetectable		 3vm4A-4gfjA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 10 ALA A 581
ILE A 568
ILE A 565
LEU A 552
ILE A 562
 None
 1.24A 4dtaA-4gfjA:
2.2		 4dtaA-4gfjA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 8 ALA A 113
THR A 333
VAL A 337
PHE A 319
 None
 0.97A 4ltwA-4gfjA:
undetectable		 4ltwA-4gfjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.99A 4pwjA-4gfjA:
undetectable		 4pwjA-4gfjA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.94A 4pwjB-4gfjA:
undetectable		 4pwjB-4gfjA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 LEU A 207
THR A 198
LEU A 209
SER A 210
 None
 0.91A 5bojB-4gfjA:
undetectable		 5bojB-4gfjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 THR A 508
ASP A 509
ALA A 510
 None
 0.05A 5g5gB-4gfjA:
undetectable		 5g5gB-4gfjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.89A 5iy5N-4gfjA:
2.4
5iy5W-4gfjA:
undetectable		 5iy5N-4gfjA:
20.06
5iy5W-4gfjA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 PHE A 374
ILE A 380
MET A 391
ILE A 408
PRO A 434
 None
 1.41A 5mlmA-4gfjA:
undetectable		 5mlmA-4gfjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ARG A 135
ASN A 136
SER A  65
GLY A  64
THR A  63
 None
 1.22A 5oj0A-4gfjA:
undetectable		 5oj0A-4gfjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		3 / 3 VAL A  80
TYR A  77
GLN A  78
 None
 0.74A 5qgkA-4gfjA:
undetectable		 5qgkA-4gfjA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 7 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.84A 5xdxA-4gfjA:
2.5
5xdxJ-4gfjA:
undetectable		 5xdxA-4gfjA:
20.06
5xdxJ-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 1.02A 5z86N-4gfjA:
1.4
5z86W-4gfjA:
undetectable		 5z86N-4gfjA:
20.06
5z86W-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 1.03A 5zcoN-4gfjA:
2.5
5zcoW-4gfjA:
undetectable		 5zcoN-4gfjA:
20.06
5zcoW-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 12 ALA A 366
ALA A 367
LEU A 356
ALA A 401
LEU A 343
 None
 1.04A 6a60D-4gfjA:
undetectable		 6a60D-4gfjA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		5 / 11 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.47A 6bm5A-4gfjA:
undetectable		 6bm5A-4gfjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 1.01A 6e43A-4gfjA:
undetectable		 6e43A-4gfjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 1.01A 6e43B-4gfjA:
2.1		 6e43B-4gfjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 1.01A 6e43C-4gfjA:
undetectable		 6e43C-4gfjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
LEU A 154
LEU A 146
ARG A 151
 None
 0.99A 6e43D-4gfjA:
undetectable		 6e43D-4gfjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4gfj TOPOISOMERASE V
(Methanopyrus
kandleri) 		4 / 6 VAL A 232
PRO A 180
ILE A 181
GLU A 185
 None
 1.16A 6h7uA-4gfjA:
1.8		 6h7uA-4gfjA:
20.03