SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 4gft NANOBODY
(Lama
glama) 		4 / 7 ASP B  64
VAL B  66
GLY B  52
ILE B  53
 None
 0.77A 1t7iB-4gftB:
undetectable		 1t7iB-4gftB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 4gft NANOBODY
(Lama
glama) 		4 / 7 ASP B  64
VAL B  66
GLY B  52
ILE B  53
 None
 0.80A 1t7jB-4gftB:
undetectable		 1t7jB-4gftB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4gft NANOBODY
(Lama
glama) 		3 / 3 LYS B   3
TYR B  34
PRO B  27
 PCA  B   2 ( 3.5A)
None
PCA  B   2 ( 4.5A)
 1.44A 2j9cC-4gftB:
undetectable		 2j9cC-4gftB:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4gft MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN
(Plasmodium
falciparum) 		5 / 12 LEU A 203
ALA A 183
ASP A 201
ILE A 145
LEU A 144
 None
 1.00A 2jn3A-4gftA:
undetectable		 2jn3A-4gftA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 4gft MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN
NANOBODY
(Lama
glama;
Plasmodium
falciparum) 		5 / 11 LEU A 203
VAL B 105
TYR B 115
TYR B  34
LEU A 175
 None
None
PCA  B   2 ( 3.9A)
None
None
 1.08A 3bgrA-4gftA:
undetectable
3bgrB-4gftA:
undetectable		 3bgrA-4gftA:
7.99
3bgrB-4gftA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4gft NANOBODY
(Lama
glama) 		4 / 8 ASP B  64
VAL B  66
GLY B  52
ILE B  53
 None
 0.78A 3nu9A-4gftB:
undetectable		 3nu9A-4gftB:
18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4gft NANOBODY
(Lama
glama) 		6 / 12 LEU B   5
MET B  36
ARG B  74
VAL B  81
ALA B 100
TYR B 115
 None
None
None
None
None
PCA  B   2 ( 3.9A)
 0.34A 3qxtB-4gftB:
22.5		 3qxtB-4gftB:
66.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4gft NANOBODY
(Lama
glama) 		6 / 12 MET B  36
ARG B  74
ASN B  76
VAL B  81
ALA B 100
TYR B 115
 None
None
None
None
None
PCA  B   2 ( 3.9A)
 0.32A 3qxvA-4gftB:
22.6		 3qxvA-4gftB:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4gft NANOBODY
(Lama
glama) 		5 / 12 MET B  36
ARG B  74
VAL B  81
ALA B 100
TYR B 115
 None
None
None
None
PCA  B   2 ( 3.9A)
 0.35A 3qxvB-4gftB:
22.2		 3qxvB-4gftB:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4gft NANOBODY
(Lama
glama) 		5 / 11 MET B  36
ARG B  74
ASN B  76
VAL B  81
ALA B 100
 None
 0.26A 3qxvC-4gftB:
22.7		 3qxvC-4gftB:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4gft NANOBODY
(Lama
glama) 		5 / 12 MET B  36
ARG B  74
VAL B  81
ALA B 100
TYR B 115
 None
None
None
None
PCA  B   2 ( 3.9A)
 0.38A 3qxvD-4gftB:
22.0		 3qxvD-4gftB:
66.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4gft NANOBODY
(Lama
glama) 		5 / 12 MET B  36
ARG B  74
VAL B  81
ALA B 100
TYR B 115
 None
None
None
None
PCA  B   2 ( 3.9A)
 0.37A 3qxvE-4gftB:
18.6		 3qxvE-4gftB:
66.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4gft MYOSIN A TAIL DOMAIN
INTERACTING PROTEIN
NANOBODY
(Plasmodium
falciparum;
Lama
glama) 		4 / 8 PHE B  31
TYR B  34
GLU A 179
GLU B  28
 None
None
PCA  B   2 ( 3.7A)
None
 1.07A 3rqwC-4gftB:
2.5
3rqwD-4gftB:
undetectable		 3rqwC-4gftB:
17.38
3rqwD-4gftB:
17.38