SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gg2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 ALA A  68
LEU A  89
ARG A 147
GLN A 146
ILE A 138
 None
 1.11A 1drfA-4gg2A:
undetectable		 1drfA-4gg2A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 TYR A 229
ILE A 241
VAL A 132
ALA A 258
GLY A  86
 None
None
None
IOD  A 408 (-4.0A)
None
 1.20A 1kiaB-4gg2A:
undetectable		 1kiaB-4gg2A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 9 ALA A 106
LEU A  91
ILE A  69
LEU A  73
ILE A 138
 None
 1.33A 3jw3B-4gg2A:
undetectable		 3jw3B-4gg2A:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN
(Homo
sapiens) 		4 / 8 GLY A 140
ILE A  93
ASP A  66
SER A  63
 None
None
None
NAG  A 401 ( 4.0A)
 0.83A 3pwwA-4gg2A:
undetectable		 3pwwA-4gg2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 PRO A 159
ALA A  57
TYR A 141
ILE A 138
GLY A  86
 None
 1.08A 4l9qA-4gg2A:
undetectable		 4l9qA-4gg2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 VAL A 248
ALA A 250
ILE A 237
THR A 234
 None
NAG  A 403 ( 4.4A)
None
NAG  A 403 (-3.4A)
 1.11A 5e4dB-4gg2A:
undetectable		 5e4dB-4gg2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 231
SER A 232
LEU A 233
LEU A 220
GLU A 223
 NAG  A 403 (-3.2A)
None
None
None
None
 1.12A 5hwkA-4gg2A:
undetectable		 5hwkA-4gg2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4gg2 GAMMA-GLUTAMYLTRANSP
EPTIDASE 1 HEAVY
CHAIN
(Homo
sapiens) 		5 / 10 GLY A 231
SER A 232
LEU A 233
LEU A 220
GLU A 223
 NAG  A 403 (-3.2A)
None
None
None
None
 1.11A 5hwkB-4gg2A:
undetectable		 5hwkB-4gg2A:
19.67