SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gga'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 HIS A 301
HIS A 267
VAL A 312
LEU A 305
THR A 304
 None
 1.28A 1zgfA-4ggaA:
undetectable		 1zgfA-4ggaA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 11 HIS A 267
HIS A 301
VAL A 302
SER A 266
ASP A 294
 None
 1.37A 2zwgA-4ggaA:
undetectable
2zwgB-4ggaA:
undetectable		 2zwgA-4ggaA:
23.56
2zwgB-4ggaA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 SER A 266
HIS A 293
GLY A 288
VAL A 312
GLY A 284
 None
 0.96A 3f8wB-4ggaA:
undetectable		 3f8wB-4ggaA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 SER A 266
HIS A 293
GLY A 288
VAL A 312
GLY A 284
 None
 0.97A 3f8wC-4ggaA:
undetectable		 3f8wC-4ggaA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 GLU A 249
GLY A 244
ARG A 270
VAL A 232
ILE A 229
 None
 1.22A 3jb2A-4ggaA:
undetectable		 3jb2A-4ggaA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 8 TRP A 407
PHE A 473
PRO A 365
TRP A 366
 None
 1.22A 3v35A-4ggaA:
undetectable		 3v35A-4ggaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 12 PHE A 473
LEU A 449
ILE A 405
GLY A 417
LEU A 439
 None
 1.12A 4dm8B-4ggaA:
undetectable		 4dm8B-4ggaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 8 ASN A 196
ALA A 211
SER A 210
ARG A 174
 None
 1.12A 4ijiF-4ggaA:
undetectable		 4ijiF-4ggaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 ASN A 196
ALA A 211
SER A 210
ARG A 174
 None
 1.14A 4ijiH-4ggaA:
undetectable		 4ijiH-4ggaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 176
THR A 457
ALA A 459
THR A 450
 None
 0.91A 4ik7A-4ggaA:
undetectable		 4ik7A-4ggaA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 THR A 457
ALA A 459
SER A 448
THR A 450
 None
 0.56A 4pwjB-4ggaA:
undetectable		 4pwjB-4ggaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 4 ASN A 329
SER A 378
ALA A 357
VAL A 358
 None
 0.77A 4x1kC-4ggaA:
undetectable		 4x1kC-4ggaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 7 THR A 457
ALA A 459
SER A 448
THR A 450
 None
 0.68A 5bojB-4ggaA:
undetectable		 5bojB-4ggaA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		4 / 4 ASN A 329
SER A 378
ALA A 357
VAL A 358
 None
 0.76A 5nm5A-4ggaA:
undetectable		 5nm5A-4ggaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		3 / 3 HIS A 300
HIS A 301
HIS A 291
 None
 0.81A 5oexA-4ggaA:
9.2		 5oexA-4ggaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens) 		5 / 11 HIS A 267
HIS A 301
VAL A 302
SER A 266
ASP A 294
 None
 1.39A 5z0mA-4ggaA:
undetectable
5z0mB-4ggaA:
1.3		 5z0mA-4ggaA:
10.86
5z0mB-4ggaA:
11.25