SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ggj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 GLN A 102
ILE A 141
HIS A 111
 None
 0.51A 1fm9A-4ggjA:
undetectable		 1fm9A-4ggjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 GLN A 102
ILE A 141
HIS A 111
 None
 0.53A 1k74A-4ggjA:
undetectable		 1k74A-4ggjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		5 / 11 VAL A 115
LEU A  84
LEU A  91
LEU A  54
LEU A  81
 None
 1.06A 1mx1B-4ggjA:
undetectable		 1mx1B-4ggjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 CYH A  66
CYH A  49
HIS A  72
 ZN  A 301 (-2.2A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.73A 2iwkA-4ggjA:
undetectable		 2iwkA-4ggjA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 CYH A  68
CYH A  49
HIS A  72
 ZN  A 301 (-2.1A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.86A 2iwkA-4ggjA:
undetectable		 2iwkA-4ggjA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 CYH A  66
CYH A  49
HIS A  72
 ZN  A 301 (-2.2A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.76A 2iwkB-4ggjA:
undetectable		 2iwkB-4ggjA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 CYH A  68
CYH A  49
HIS A  72
 ZN  A 301 (-2.1A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.85A 2iwkB-4ggjA:
undetectable		 2iwkB-4ggjA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		5 / 12 LEU A  84
PHE A  98
GLY A 104
VAL A 183
ILE A 165
 None
 0.92A 3c6gA-4ggjA:
undetectable		 3c6gA-4ggjA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 CYH A  66
CYH A  49
HIS A  72
 ZN  A 301 (-2.2A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.73A 3dtuB-4ggjA:
undetectable		 3dtuB-4ggjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 CYH A  66
CYH A  49
HIS A  72
 ZN  A 301 (-2.2A)
ZN  A 301 (-2.2A)
ZN  A 301 (-3.3A)
 0.71A 3dtuD-4ggjA:
undetectable		 3dtuD-4ggjA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 PHE A 156
CYH A  94
HIS A 154
 None
 1.08A 3u9fF-4ggjA:
undetectable		 3u9fF-4ggjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 PHE A 156
CYH A  94
HIS A 154
 None
 1.09A 3u9fG-4ggjA:
undetectable		 3u9fG-4ggjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 PHE A 156
CYH A  94
HIS A 154
 None
 0.95A 3u9fL-4ggjA:
undetectable		 3u9fL-4ggjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 PHE A 156
CYH A  94
HIS A 154
 None
 1.15A 3u9fS-4ggjA:
undetectable		 3u9fS-4ggjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 TYR A 125
ARG A 137
HIS A 145
 None
 1.20A 4fubA-4ggjA:
undetectable		 4fubA-4ggjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		5 / 11 LEU A 103
TRP A 171
ILE A 165
LEU A 110
LEU A  91
 None
 1.22A 4yvpA-4ggjA:
undetectable		 4yvpA-4ggjA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		5 / 12 LEU A 103
TRP A 171
ILE A 165
LEU A 110
LEU A  91
 None
 1.24A 4yvpB-4ggjA:
undetectable		 4yvpB-4ggjA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		4 / 8 ILE A 141
VAL A 143
GLN A 132
SER A 131
 None
 0.93A 5dqyA-4ggjA:
undetectable		 5dqyA-4ggjA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		3 / 3 GLN A 102
ILE A 141
HIS A 111
 None
 0.62A 5z12B-4ggjA:
undetectable		 5z12B-4ggjA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE
(Mus
musculus) 		5 / 11 VAL A 183
PHE A  43
ILE A 176
ALA A 175
ALA A  97
 None
 1.09A 6h1lB-4ggjA:
undetectable		 6h1lB-4ggjA:
17.52