SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ggp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 12 ASN A  95
CYH A  20
GLY A  83
SER A  84
THR A  86
 None
 1.26A 1g60A-4ggpA:
2.2		 1g60A-4ggpA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 7 ALA A 280
PHE A 169
PRO A 164
THR A 244
 None
 1.05A 2q6oA-4ggpA:
undetectable		 2q6oA-4ggpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 8 HIS A  16
GLY A  19
PHE A 394
TYR A  94
 None
 1.42A 3ccfA-4ggpA:
4.5		 3ccfA-4ggpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 9 VAL A 141
LEU A 319
ILE A 334
ILE A 308
GLY A  57
 None
 1.16A 3cv9A-4ggpA:
undetectable		 3cv9A-4ggpA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 12 PHE A 165
ALA A 189
ALA A 194
THR A 197
VAL A 161
 None
 1.17A 3cwkA-4ggpA:
undetectable		 3cwkA-4ggpA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 8 TYR A 230
ASP A 338
GLU A 317
GLU A 305
 None
 1.44A 3dh0A-4ggpA:
5.3		 3dh0A-4ggpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 5 TYR A 230
ASP A 338
GLU A 317
GLU A 305
 None
 1.47A 3dh0B-4ggpA:
5.1		 3dh0B-4ggpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 8 LEU A 314
GLY A  69
ALA A  67
THR A  74
 None
 0.73A 3jusA-4ggpA:
undetectable		 3jusA-4ggpA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 8 LEU A 314
GLY A  69
ALA A  67
THR A  74
 None
 0.73A 3jusA-4ggpA:
undetectable		 3jusA-4ggpA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 5 GLY A 246
LYS A 247
GLU A 250
GLY A 243
 None
 0.87A 3onnA-4ggpA:
4.1		 3onnA-4ggpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 12 ILE A 224
LEU A 226
ALA A  66
THR A  74
VAL A 141
 None
 1.03A 3rukA-4ggpA:
undetectable		 3rukA-4ggpA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 6 SER A 110
LEU A 108
THR A  74
ARG A  63
 None
 1.27A 3thrB-4ggpA:
6.4		 3thrB-4ggpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 4 MET A 353
SER A 293
LEU A 289
VAL A 356
 None
 1.44A 3vlnA-4ggpA:
undetectable		 3vlnA-4ggpA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 12 PHE A 137
TYR A 109
ASN A  96
SER A  78
LEU A  50
 None
 1.44A 4a83A-4ggpA:
undetectable		 4a83A-4ggpA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 12 TYR A 109
GLU A 128
VAL A  77
ILE A 122
ILE A 127
 None
 1.44A 4a99A-4ggpA:
3.8
4a99C-4ggpA:
3.8		 4a99A-4ggpA:
21.76
4a99C-4ggpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 11 LEU A 213
ILE A 210
ARG A 267
LEU A  52
ILE A 135
 None
 1.17A 4dm8A-4ggpA:
undetectable		 4dm8A-4ggpA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 12 ASN A  48
LEU A 139
VAL A  51
CYH A  54
LEU A  60
 None
 1.42A 4k36A-4ggpA:
2.3		 4k36A-4ggpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 12 ASN A  48
LEU A 139
VAL A  51
CYH A  54
LEU A  60
 None
 1.38A 4k36B-4ggpA:
2.4		 4k36B-4ggpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		4 / 6 ALA A  61
THR A 312
THR A  31
TYR A  30
 None
 1.45A 4z4iA-4ggpA:
2.4		 4z4iA-4ggpA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4ggp TRANS-2-ENOYL-COA
REDUCTASE
(Treponema
denticola) 		5 / 12 TYR A 228
LEU A 226
ILE A 311
THR A  31
LEU A  52
 None
 1.38A 6djzB-4ggpA:
undetectable		 6djzB-4ggpA:
19.70