SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ggv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		4 / 6 LEU A 250
ILE A 124
GLU A 123
PRO A 378
 None
 1.03A 1ditH-4ggvA:
undetectable
1ditP-4ggvA:
undetectable		 1ditH-4ggvA:
20.43
1ditP-4ggvA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		4 / 5 LEU A 221
GLU A 219
ALA A 214
LEU A 211
 None
 1.06A 1eta1-4ggvA:
undetectable		 1eta1-4ggvA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		4 / 5 LEU A 221
GLU A 219
ALA A 214
LEU A 211
 None
 1.00A 1eta2-4ggvA:
undetectable		 1eta2-4ggvA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 PHE A 381
PHE A 380
PRO A 378
THR A 372
ILE A 124
 None
 1.30A 1fm4A-4ggvA:
undetectable		 1fm4A-4ggvA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		4 / 8 THR A 244
ALA A 352
GLY A 338
ALA A 349
 HEM  A 401 (-3.4A)
HEM  A 401 ( 3.7A)
None
None
 0.74A 1gtnI-4ggvA:
undetectable
1gtnJ-4ggvA:
undetectable		 1gtnI-4ggvA:
10.28
1gtnJ-4ggvA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 VAL A   4
LEU A 280
SER A 281
LEU A 277
THR A   3
 None
 1.34A 1kw0A-4ggvA:
undetectable		 1kw0A-4ggvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 11 THR A 109
LEU A 354
VAL A 358
GLY A 356
ILE A 108
 None
 1.18A 1phgA-4ggvA:
35.5		 1phgA-4ggvA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		4 / 6 LEU A 221
GLU A 219
ALA A 214
LEU A 211
 None
 1.06A 2roxB-4ggvA:
undetectable		 2roxB-4ggvA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		4 / 8 ILE A 273
GLY A 356
LEU A 128
PHE A 364
 None
 0.87A 2vctC-4ggvA:
undetectable		 2vctC-4ggvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		4 / 7 ILE A 273
GLY A 356
LEU A 128
PHE A 364
 None
 0.97A 2vctD-4ggvA:
undetectable		 2vctD-4ggvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 GLY A  33
GLN A  32
LEU A 168
THR A 290
ILE A 301
 None
 1.27A 4p6xA-4ggvA:
undetectable		 4p6xA-4ggvA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		3 / 5 GLY A 164
GLY A 161
GLU A 160
 None
 0.41A 4z2eA-4ggvA:
undetectable
4z2eD-4ggvA:
undetectable		 4z2eA-4ggvA:
22.62
4z2eD-4ggvA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 LEU A 277
THR A 241
GLU A 274
GLY A 356
PHE A 339
 None
HEM  A 401 ( 4.4A)
None
None
HEM  A 401 (-4.7A)
 1.48A 5axaC-4ggvA:
undetectable		 5axaC-4ggvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 LEU A 188
GLY A 194
ALA A 230
VAL A 143
ASN A 231
 None
 1.12A 5kbwB-4ggvA:
undetectable		 5kbwB-4ggvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 LEU A 277
THR A 241
GLU A 274
GLY A 356
PHE A 339
 None
HEM  A 401 ( 4.4A)
None
None
HEM  A 401 (-4.7A)
 1.47A 5m5kB-4ggvA:
undetectable		 5m5kB-4ggvA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 LEU A 277
THR A 241
GLU A 274
GLY A 356
PHE A 339
 None
HEM  A 401 ( 4.4A)
None
None
HEM  A 401 (-4.7A)
 1.47A 5v96A-4ggvA:
undetectable		 5v96A-4ggvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 LEU A 277
THR A 241
GLU A 274
GLY A 356
PHE A 339
 None
HEM  A 401 ( 4.4A)
None
None
HEM  A 401 (-4.7A)
 1.46A 5v96C-4ggvA:
undetectable		 5v96C-4ggvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_1
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 LEU A 277
THR A 241
GLU A 274
GLY A 356
PHE A 339
 None
HEM  A 401 ( 4.4A)
None
None
HEM  A 401 (-4.7A)
 1.48A 5v96D-4ggvA:
undetectable		 5v96D-4ggvA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 LEU A  47
ILE A  46
GLY A  39
LEU A 311
PHE A 339
 None
None
None
None
HEM  A 401 (-4.7A)
 1.26A 6a7pA-4ggvA:
undetectable		 6a7pA-4ggvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 12 LEU A 277
THR A 241
GLU A 274
LEU A 360
PHE A 339
 None
HEM  A 401 ( 4.4A)
None
None
HEM  A 401 (-4.7A)
 1.01A 6aphA-4ggvA:
undetectable		 6aphA-4ggvA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN
(Streptomyces
himastatinicus) 		5 / 11 VAL A 105
THR A 109
LEU A 351
ALA A 359
VAL A 134
 None
 1.32A 6dryA-4ggvA:
undetectable		 6dryA-4ggvA:
20.39