SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gh4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4gh4 CAPSID PROTEIN VP1
(Foot-and-mouth
disease
virus) 		3 / 3 ASP A  75
TYR A 119
GLU A 183
 None
 0.81A 1vm1A-4gh4A:
undetectable		 1vm1A-4gh4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP3
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		5 / 7 TYR A 107
GLY A 102
THR C  16
ASP C 217
ASN A 103
 None
 1.40A 2g70A-4gh4A:
undetectable		 2g70A-4gh4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP3
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		5 / 7 TYR A 107
GLY A 102
THR C  16
ASP C 217
ASN A 103
 None
 1.40A 2g70B-4gh4A:
undetectable		 2g70B-4gh4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y04_B_68HB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4gh4 CAPSID PROTEIN VP3
(Foot-and-mouth
disease
virus) 		5 / 12 THR C 112
VAL C 201
VAL C 202
PHE C  57
TYR C 121
 None
 1.26A 2y04B-4gh4C:
undetectable		 2y04B-4gh4C:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 4gh4 CAPSID PROTEIN VP1
(Foot-and-mouth
disease
virus) 		4 / 6 ASN A  91
SER A 161
ALA A 121
HIS A 123
 None
 1.38A 3aruA-4gh4A:
undetectable		 3aruA-4gh4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4gh4 CAPSID PROTEIN VP3
(Foot-and-mouth
disease
virus) 		5 / 12 THR C 112
VAL C 201
VAL C 202
PHE C  57
TYR C 121
 None
 1.24A 3d4sA-4gh4C:
undetectable		 3d4sA-4gh4C:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4gh4 CAPSID PROTEIN VP2
CAPSID PROTEIN VP3
(Foot-and-mouth
disease
virus) 		3 / 3 TYR C 125
TYR B 100
GLY C 183
 None
 0.73A 3eteB-4gh4C:
undetectable
3eteD-4gh4C:
undetectable
3eteF-4gh4C:
undetectable		 3eteB-4gh4C:
17.72
3eteD-4gh4C:
17.72
3eteF-4gh4C:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		5 / 12 LEU B 163
TYR A 130
PRO B 176
GLY A 132
THR A 133
 None
 1.04A 3okxA-4gh4B:
undetectable		 3okxA-4gh4B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		5 / 12 LEU B 163
TYR A 130
PRO B 176
GLY A 132
THR A 133
 None
 1.07A 3okxB-4gh4B:
undetectable		 3okxB-4gh4B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4gh4 CAPSID PROTEIN VP1
(Foot-and-mouth
disease
virus) 		5 / 10 ALA A 121
LEU A 126
LEU A  53
ALA A 182
VAL A  62
 None
 1.16A 3r9cA-4gh4A:
undetectable		 3r9cA-4gh4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4gh4 CAPSID PROTEIN VP1
(Foot-and-mouth
disease
virus) 		4 / 8 ILE A  42
ILE A  78
LEU A  76
ILE A  51
 None
 0.85A 4dtaB-4gh4A:
undetectable		 4dtaB-4gh4A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4gh4 CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus) 		3 / 3 PHE B  62
TYR B 171
TYR B  91
 None
 0.98A 4ffwA-4gh4B:
undetectable		 4ffwA-4gh4B:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4gh4 CAPSID PROTEIN VP1
(Foot-and-mouth
disease
virus) 		5 / 12 LEU A 126
LEU A  76
MET A 179
THR A  56
ILE A  42
 None
 1.28A 4okbA-4gh4A:
undetectable		 4okbA-4gh4A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP3
(Foot-and-mouth
disease
virus) 		4 / 5 ALA C 172
TYR C 170
HIS A  49
PRO A  90
 None
 1.16A 4ze2A-4gh4C:
undetectable		 4ze2A-4gh4C:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4gh4 CAPSID PROTEIN VP2
CAPSID PROTEIN VP3
(Foot-and-mouth
disease
virus) 		3 / 3 PRO C 134
ILE C 105
SER B 216
 None
 0.81A 5fsaA-4gh4C:
undetectable		 5fsaA-4gh4C:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus) 		5 / 12 ILE B 197
VAL B 109
VAL B 123
GLY A   5
THR A   4
 None
 1.04A 5igiA-4gh4B:
undetectable		 5igiA-4gh4B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus) 		5 / 12 ILE B 197
VAL B 109
VAL B 123
GLY A   5
THR A   4
 None
 1.04A 5igjA-4gh4B:
undetectable		 5igjA-4gh4B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		5 / 12 ILE B 197
VAL B 109
VAL B 123
GLY A   5
THR A   4
 None
 1.04A 5igtA-4gh4B:
undetectable		 5igtA-4gh4B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		3 / 3 PRO A 189
ARG A 188
GLU B 136
 None
 0.95A 5j6hA-4gh4A:
undetectable		 5j6hA-4gh4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4gh4 CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus) 		3 / 3 VAL B  43
ARG B  60
PRO B 205
 None
 0.79A 5koxA-4gh4B:
undetectable		 5koxA-4gh4B:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4gh4 CAPSID PROTEIN VP1
(Foot-and-mouth
disease
virus) 		4 / 7 LEU A 184
ILE A  42
THR A  56
MET A 179
 None
 1.15A 5ljcA-4gh4A:
undetectable		 5ljcA-4gh4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4gh4 CAPSID PROTEIN VP3
(Foot-and-mouth
disease
virus) 		5 / 9 LEU C  91
GLY C  93
SER C 205
VAL C  47
LEU C  45
 None
 1.18A 5o96E-4gh4C:
undetectable
5o96F-4gh4C:
undetectable		 5o96E-4gh4C:
22.55
5o96F-4gh4C:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4gh4 CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus) 		3 / 3 GLU B  59
HIS B 207
ARG B 102
 None
 0.93A 5uunA-4gh4B:
undetectable		 5uunA-4gh4B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4gh4 CAPSID PROTEIN VP4
(Foot-and-mouth
disease
virus) 		3 / 3 SER D  69
LYS D  70
SER D  73
 None
 0.52A 6az3P-4gh4D:
undetectable		 6az3P-4gh4D:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4gh4 CAPSID PROTEIN VP2
(Foot-and-mouth
disease
virus) 		4 / 7 TRP B 177
ARG B 102
GLU B  40
ASP B  41
 None
 1.41A 6mn4F-4gh4B:
undetectable		 6mn4F-4gh4B:
20.63