SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gh7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN5_C_T3C601_2 (TRANSTHYRETIN)	4gh7	NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN (Homo sapiens)	4 / 8	LEU A 144 THR A 136 LEU A 148 VAL A 121	None	0.96A	1sn5C-4gh7A: undetectable	1sn5C-4gh7A: 18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TLS_A_C2FA266_0 (THYMIDYLATE SYNTHASE)	4gh7	NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN (Homo sapiens)	5 / 12	ILE A 153 LEU A 159 LEU A 137 GLY A 35 PHE A 168	None	1.12A	1tlsA-4gh7A: undetectable	1tlsA-4gh7A: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TLS_B_C2FB266_0 (THYMIDYLATE SYNTHASE)	4gh7	NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN (Homo sapiens)	5 / 12	ILE A 153 LEU A 159 LEU A 137 GLY A 35 PHE A 168	None	1.05A	1tlsB-4gh7A: undetectable	1tlsB-4gh7A: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TSN_A_C2FA266_0 (THYMIDYLATE SYNTHASE)	4gh7	NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN (Homo sapiens)	5 / 12	ILE A 153 LEU A 159 LEU A 137 GLY A 35 PHE A 168	None	1.12A	1tsnA-4gh7A: undetectable	1tsnA-4gh7A: 21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QBM_A_CAMA517_0 (CYTOCHROME P450-CAM)	4gh7	NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN (Homo sapiens)	4 / 8	PHE A 27 THR A 54 THR A 136 VAL A 108	None	0.79A	2qbmA-4gh7A: undetectable	2qbmA-4gh7A: 16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QBM_A_CAMA517_0 (CYTOCHROME P450-CAM)	4gh7	NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN (Homo sapiens)	4 / 8	PHE A 83 THR A 54 VAL A 121 THR A 136	None	0.96A	2qbmA-4gh7A: undetectable	2qbmA-4gh7A: 16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QBM_A_CAMA517_0 (CYTOCHROME P450-CAM)	4gh7	NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN (Homo sapiens)	4 / 8	TYR A 56 THR A 54 VAL A 121 THR A 136	None	0.94A	2qbmA-4gh7A: undetectable	2qbmA-4gh7A: 16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FOG_D_C2FD302_0 (THYMIDYLATE SYNTHASE)	4gh7	NEUTROPHIL GELATINASE-ASSOCIATE D LIPOCALIN (Homo sapiens)	5 / 11	ILE A 153 LEU A 159 LEU A 137 GLY A 35 PHE A 168	None	1.19A	4fogD-4gh7A: undetectable	4fogD-4gh7A: 23.02

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SN5_C_T3C601_2","TRANSTHYRETIN","4gh7","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Homo sapiens",4,"LEU A 144;THR A 136;LEU A 148;VAL A 121","None","0.96A","1sn5C-4gh7A:undetectable","1sn5C-4gh7A:18.38"],["1TLS_A_C2FA266_0","THYMIDYLATE SYNTHASE","4gh7","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Homo sapiens",5,"ILE A 153;LEU A 159;LEU A 137;GLY A  35;PHE A 168","None","1.12A","1tlsA-4gh7A:undetectable","1tlsA-4gh7A:21.93"],["1TLS_B_C2FB266_0","THYMIDYLATE SYNTHASE","4gh7","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Homo sapiens",5,"ILE A 153;LEU A 159;LEU A 137;GLY A  35;PHE A 168","None","1.05A","1tlsB-4gh7A:undetectable","1tlsB-4gh7A:21.93"],["1TSN_A_C2FA266_0","THYMIDYLATE SYNTHASE","4gh7","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Homo sapiens",5,"ILE A 153;LEU A 159;LEU A 137;GLY A  35;PHE A 168","None","1.12A","1tsnA-4gh7A:undetectable","1tsnA-4gh7A:21.93"],["2QBM_A_CAMA517_0","CYTOCHROME P450-CAM","4gh7","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Homo sapiens",4,"PHE A  27;THR A  54;THR A 136;VAL A 108","None","0.79A","2qbmA-4gh7A:undetectable","2qbmA-4gh7A:16.08"],["2QBM_A_CAMA517_0","CYTOCHROME P450-CAM","4gh7","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Homo sapiens",4,"PHE A  83;THR A  54;VAL A 121;THR A 136","None","0.96A","2qbmA-4gh7A:undetectable","2qbmA-4gh7A:16.08"],["2QBM_A_CAMA517_0","CYTOCHROME P450-CAM","4gh7","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Homo sapiens",4,"TYR A  56;THR A  54;VAL A 121;THR A 136","None","0.94A","2qbmA-4gh7A:undetectable","2qbmA-4gh7A:16.08"],["4FOG_D_C2FD302_0","THYMIDYLATE SYNTHASE","4gh7","NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN","Homo sapiens",5,"ILE A 153;LEU A 159;LEU A 137;GLY A  35;PHE A 168","None","1.19A","4fogD-4gh7A:undetectable","4fogD-4gh7A:23.02"]]