SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ghb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 8 TYR A 142
GLY A 251
PRO A 253
GLU A 252
 None
None
GOL  A 413 ( 4.5A)
None
 0.97A 2ys6A-4ghbA:
undetectable		 2ys6A-4ghbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 7 THR A 115
VAL A 124
THR A 126
VAL A 132
 None
 0.46A 3em0B-4ghbA:
undetectable		 3em0B-4ghbA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 7 THR A 147
VAL A 132
THR A 134
VAL A 124
 None
 0.37A 3em0B-4ghbA:
undetectable		 3em0B-4ghbA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 6 ILE A 164
PRO A  58
ILE A 245
GLY A 251
 None
 0.80A 3n3iA-4ghbA:
undetectable		 3n3iA-4ghbA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 6 ILE A  65
VAL A 285
LEU A 279
ILE A 284
 None
 0.93A 4asdA-4ghbA:
undetectable		 4asdA-4ghbA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 4 ASN A  87
ALA A  89
GLY A  90
THR A  59
 SO4  A 402 (-4.5A)
None
GOL  A 412 (-3.5A)
GOL  A 412 ( 3.9A)
 1.26A 4bboC-4ghbA:
undetectable		 4bboC-4ghbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 8 ALA A 254
ASP A 234
ILE A 232
ILE A 188
 GOL  A 406 (-3.9A)
None
GOL  A 413 ( 4.2A)
None
 0.84A 4kttB-4ghbA:
undetectable		 4kttB-4ghbA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		4 / 5 LEU A 172
TYR A 162
ALA A 143
ILE A 249
 None
 1.17A 4y03B-4ghbA:
undetectable		 4y03B-4ghbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		3 / 3 TYR A 236
TYR A 135
SER A 148
 None
None
GOL  A 414 ( 4.0A)
 0.99A 5iktB-4ghbA:
undetectable		 5iktB-4ghbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4ghb HYPOTHETICAL PROTEIN
(Bacteroides
uniformis) 		3 / 3 LEU A 238
ILE A 188
TYR A 192
 None
None
GOL  A 406 (-4.8A)
 0.61A 5uunB-4ghbA:
undetectable		 5uunB-4ghbA:
20.06