SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ghk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 5 THR A 260
GLU A 318
THR A 317
HIS A 231
 None
 1.11A 1d4fB-4ghkA:
3.2		 1d4fB-4ghkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		5 / 9 VAL A 203
GLY A 121
THR A 145
ILE A 122
SER A 141
 None
 1.15A 1gtnL-4ghkA:
undetectable
1gtnM-4ghkA:
undetectable		 1gtnL-4ghkA:
10.36
1gtnM-4ghkA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 TYR A 282
LEU A 278
LEU A 275
THR A 376
LEU A 289
 None
 1.24A 1tw4B-4ghkA:
undetectable		 1tw4B-4ghkA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 6 ARG A 186
THR A 183
ALA A 184
ARG A 148
 None
 1.30A 2ql8A-4ghkA:
undetectable
2ql8B-4ghkA:
undetectable		 2ql8A-4ghkA:
14.02
2ql8B-4ghkA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 7 ILE A  21
ILE A 390
LEU A 173
LEU A 147
 None
 0.95A 3adxA-4ghkA:
undetectable		 3adxA-4ghkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 THR A 145
VAL A 178
VAL A 189
ILE A 123
TYR A 124
 None
 1.47A 3em0A-4ghkA:
undetectable		 3em0A-4ghkA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 7 ASN A 157
LEU A 154
ASP A  54
SER A 126
 None
 1.33A 3lslA-4ghkA:
undetectable
3lslD-4ghkA:
undetectable		 3lslA-4ghkA:
20.04
3lslD-4ghkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		5 / 9 ALA A 134
ILE A 120
GLY A 391
ILE A 123
ILE A 122
 None
 1.02A 3s45A-4ghkA:
undetectable		 3s45A-4ghkA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 4 LEU A 386
GLY A 404
LEU A 405
GLU A 406
 None
 0.95A 3tgvB-4ghkA:
undetectable		 3tgvB-4ghkA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 5 ILE A  95
PRO A 116
SER A  20
GLY A 142
 None
 1.19A 3tkdB-4ghkA:
undetectable		 3tkdB-4ghkA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 6 ILE A 392
PHE A 384
HIS A 231
VAL A 246
 None
 1.21A 4a97I-4ghkA:
undetectable		 4a97I-4ghkA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 117
GLY A 142
ILE A 120
VAL A  88
LEU A 405
 None
 0.99A 4gc9A-4ghkA:
2.9		 4gc9A-4ghkA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		3 / 3 ASP A 348
VAL A 234
ASN A 340
 None
 0.81A 4lmnA-4ghkA:
undetectable		 4lmnA-4ghkA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		5 / 12 VAL A 403
LEU A 408
THR A 409
VAL A 203
PRO A 204
 None
 1.06A 4xiwB-4ghkA:
undetectable
4xiwE-4ghkA:
undetectable		 4xiwB-4ghkA:
20.54
4xiwE-4ghkA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 5 ARG A 148
THR A 183
ALA A 184
ASP A 185
 None
 1.45A 5mfxA-4ghkA:
3.0		 5mfxA-4ghkA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		5 / 10 THR A 131
ILE A 132
LEU A  85
GLY A 165
ALA A 161
 None
 1.19A 5mxbA-4ghkA:
undetectable		 5mxbA-4ghkA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE
(Burkholderia
thailandensis) 		4 / 8 GLN A 175
GLY A 165
GLU A 170
ASP A  43
 None
 1.07A 5vlmD-4ghkA:
undetectable		 5vlmD-4ghkA:
19.63