SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gi5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		4 / 6 TRP A 102
GLY A 154
GLY A 155
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
None
 0.34A 2qr2A-4gi5A:
30.2
2qr2B-4gi5A:
30.1		 2qr2A-4gi5A:
37.73
2qr2B-4gi5A:
37.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 176
PHE A  98
SER A  37
LEU A  88
MET A 180
 None
 1.27A 2xkwB-4gi5A:
undetectable		 2xkwB-4gi5A:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 10 PHE A 103
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-3.2A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.70A 3fw1A-4gi5A:
30.4		 3fw1A-4gi5A:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 10 TRP A 102
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.36A 3fw1A-4gi5A:
30.4		 3fw1A-4gi5A:
39.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 9 TRP A 102
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.39A 3owxA-4gi5A:
30.3		 3owxA-4gi5A:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 11 TRP A 102
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.36A 3owxA-4gi5A:
30.3
3owxB-4gi5A:
30.4		 3owxA-4gi5A:
38.10
3owxB-4gi5A:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		4 / 7 PHE A 194
PHE A  22
ALA A  23
LEU A 192
 None
 0.83A 4ejgA-4gi5A:
undetectable		 4ejgA-4gi5A:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 7 TRP A 102
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.53A 4fgkB-4gi5A:
30.1		 4fgkB-4gi5A:
39.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		4 / 5 GLY A 140
VAL A 143
PRO A 184
TYR A 183
 None
None
None
UNL  A 302 (-4.2A)
 1.19A 4grkA-4gi5A:
undetectable		 4grkA-4gi5A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		6 / 12 VAL A 193
GLY A 167
GLY A 164
ILE A 169
ILE A 172
LEU A 100
 None
None
None
None
None
FAD  A 301 (-4.4A)
 1.29A 4iv0A-4gi5A:
undetectable		 4iv0A-4gi5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 12 VAL A 193
GLY A 164
ILE A 169
ILE A 172
LEU A 100
 None
None
None
None
FAD  A 301 (-4.4A)
 0.99A 4mwzB-4gi5A:
undetectable		 4mwzB-4gi5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A  88
ILE A   6
ALA A 147
ILE A 113
MET A 105
 None
 1.25A 4rp8C-4gi5A:
undetectable		 4rp8C-4gi5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 11 ILE A 172
GLY A 167
TYR A 195
LEU A 173
VAL A 193
 None
 1.24A 5hw4B-4gi5A:
undetectable		 5hw4B-4gi5A:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LBT_A_6T0A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 10 TRP A 102
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.36A 5lbtA-4gi5A:
30.4
5lbtB-4gi5A:
30.0		 5lbtA-4gi5A:
37.63
5lbtB-4gi5A:
37.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 10 TRP A 102
GLY A 154
GLY A 155
TYR A 160
ASN A 166
 FAD  A 301 (-4.1A)
FAD  A 301 (-3.6A)
FAD  A 301 (-3.5A)
FAD  A 301 (-4.7A)
None
 0.39A 5lbtA-4gi5A:
30.4
5lbtB-4gi5A:
30.0		 5lbtA-4gi5A:
37.63
5lbtB-4gi5A:
37.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		5 / 12 PHE A 186
ALA A 211
ALA A 213
LEU A  27
LEU A 219
 None
 1.08A 6aybA-4gi5A:
undetectable		 6aybA-4gi5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4gi5 QUINONE REDUCTASE
(Klebsiella
pneumoniae) 		4 / 6 ALA A  30
SER A   0
THR A  93
ILE A  95
 None
 0.91A 6f8cA-4gi5A:
undetectable		 6f8cA-4gi5A:
15.36