SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gib'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		5 / 12 TYR A  80
TYR A  21
TRP A  24
ILE A  35
ILE A  55
 None
 1.33A 2efjA-4gibA:
2.1		 2efjA-4gibA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		4 / 6 LEU A 113
PHE A   7
PHE A 133
LEU A 124
 None
 1.08A 3wg7C-4gibA:
undetectable
3wg7J-4gibA:
undetectable		 3wg7C-4gibA:
21.28
3wg7J-4gibA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		5 / 12 ALA A 120
PHE A 133
ILE A  97
LEU A 101
ILE A 129
 None
 1.06A 4kjkA-4gibA:
undetectable		 4kjkA-4gibA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		4 / 8 ASN A  78
ASP A 138
ASN A 119
ILE A 121
 None
None
PO4  A 304 (-3.8A)
None
 1.06A 4l7iA-4gibA:
undetectable		 4l7iA-4gibA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		5 / 12 ALA A 120
PHE A 133
ILE A  97
LEU A 101
ILE A 129
 None
 1.08A 4nx6A-4gibA:
2.9		 4nx6A-4gibA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		5 / 12 ALA A 120
PHE A 133
ILE A  97
LEU A 101
ILE A 129
 None
 1.07A 4nx7A-4gibA:
4.0		 4nx7A-4gibA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		4 / 5 VAL A 123
THR A  14
ASP A  10
LEU A   9
 None
None
PO4  A 303 ( 4.9A)
PO4  A 303 (-3.9A)
 1.24A 5m0iB-4gibA:
undetectable		 5m0iB-4gibA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		5 / 12 LEU A 124
ASN A 125
LEU A 127
GLY A 128
LEU A 101
 None
 0.89A 5uc1B-4gibA:
undetectable		 5uc1B-4gibA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		4 / 5 LEU A 113
PHE A   7
PHE A 133
LEU A 124
 None
 1.11A 5x1bP-4gibA:
undetectable		 5x1bP-4gibA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		4 / 6 PHE A   7
ILE A  97
GLY A  11
TYR A  19
 None
None
NA  A 302 ( 4.7A)
None
 0.87A 5x5qE-4gibA:
undetectable		 5x5qE-4gibA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4gib BETA-PHOSPHOGLUCOMUT
ASE
(Clostridioides
difficile) 		5 / 11 ALA A 116
SER A 114
VAL A 189
ILE A 169
ILE A  97
 PO4  A 303 (-3.9A)
None
None
None
None
 1.21A 5y80A-4gibA:
undetectable		 5y80A-4gibA:
17.89