SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 12 ILE A 274
ILE A 276
ALA A 351
LEU A 336
ILE A 354
 None
 1.11A 1bsxA-4gicA:
undetectable		 1bsxA-4gicA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 12 ILE A 274
ILE A 276
ALA A 351
LEU A 336
ILE A 354
 None
 1.11A 1bsxB-4gicA:
undetectable		 1bsxB-4gicA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 12 PHE A 190
ALA A 165
THR A  57
GLY A 138
LEU A 178
 None
 1.41A 3aobC-4gicA:
undetectable		 3aobC-4gicA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 12 PHE A 190
ALA A 165
THR A  57
GLY A 138
LEU A 178
 None
 1.40A 3aodC-4gicA:
undetectable		 3aodC-4gicA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		4 / 6 ILE A 348
ASN A 350
PRO A 331
LEU A 334
 None
 1.06A 3oi8A-4gicA:
undetectable		 3oi8A-4gicA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 12 LEU A  56
THR A  57
GLY A 194
ALA A 195
ALA A 199
 None
 1.15A 3p5nA-4gicA:
undetectable		 3p5nA-4gicA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 12 LEU A  56
THR A  57
GLY A 194
ALA A 195
ALA A 199
 None
 1.15A 3p5nB-4gicA:
undetectable		 3p5nB-4gicA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 10 ALA A 273
ILE A   6
VAL A   4
ALA A 258
ILE A 290
 None
 1.06A 4lbgA-4gicA:
3.4		 4lbgA-4gicA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 9 ALA A 273
ILE A   6
VAL A   4
ALA A 258
ILE A 290
 None
 1.04A 4lbgB-4gicA:
3.0		 4lbgB-4gicA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		5 / 12 LYS A 226
ASP A 236
VAL A 132
LEU A 134
ALA A 165
 None
 1.40A 4yhaA-4gicA:
undetectable		 4yhaA-4gicA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		6 / 12 GLY A 216
ALA A 225
ILE A  41
ILE A  34
ALA A 199
PHE A  60
 None
 1.46A 5hesA-4gicA:
undetectable		 5hesA-4gicA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 4gic HISTIDINOL
DEHYDROGENASE
(Methylococcus
capsulatus) 		4 / 5 ASN A 174
VAL A 186
LEU A 162
SER A 146
 None
 1.24A 6a7pA-4gicA:
undetectable		 6a7pA-4gicA:
21.36