SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 7 TYR A 196
ASP A 140
GLU A 144
PHE A 200
 None
 1.36A 1b2iA-4gisA:
undetectable		 1b2iA-4gisA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLU A 334
GLU A 257
GLU A 231
ALA A 254
VAL A 274
 None
MG  A 405 ( 2.4A)
MG  A 405 (-2.7A)
None
None
 1.30A 1ctrA-4gisA:
undetectable		 1ctrA-4gisA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 12 TYR A 124
GLU A 231
ASP A 232
GLU A 257
ASP A 311
 None
MG  A 405 (-2.7A)
MG  A 405 ( 4.8A)
MG  A 405 ( 2.4A)
GOL  A 404 (-2.8A)
 1.46A 1dy4A-4gisA:
undetectable		 1dy4A-4gisA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 6 TYR A  35
GLY A  34
ASP A  99
GLY A 366
 None
 0.91A 1eswA-4gisA:
6.2		 1eswA-4gisA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gis ENOLASE
(Vibrio
harveyi) 		3 / 3 GLN A 283
ILE A 365
HIS A 322
 None
 0.63A 1fm9A-4gisA:
undetectable		 1fm9A-4gisA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gis ENOLASE
(Vibrio
harveyi) 		3 / 3 GLN A 283
ILE A 365
HIS A 322
 None
 0.61A 1k74A-4gisA:
undetectable		 1k74A-4gisA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 7 ASN A 320
GLY A  92
PRO A 289
ALA A 290
 None
 0.79A 1n49A-4gisA:
undetectable		 1n49A-4gisA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 12 TYR A 181
ILE A 222
ILE A 182
LEU A 135
PHE A 189
 None
 1.09A 1uduB-4gisA:
undetectable		 1uduB-4gisA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 6 LEU A 210
ALA A 219
HIS A 204
ASP A 205
 None
None
None
MG  A 405 (-2.7A)
 1.37A 2dpzA-4gisA:
undetectable		 2dpzA-4gisA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 10 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.24A 3fhjA-4gisA:
undetectable		 3fhjA-4gisA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 10 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.23A 3fhjB-4gisA:
undetectable		 3fhjB-4gisA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 10 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.24A 3fhjC-4gisA:
undetectable		 3fhjC-4gisA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.23A 3fhjD-4gisA:
undetectable		 3fhjD-4gisA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 10 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.23A 3fhjE-4gisA:
undetectable		 3fhjE-4gisA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.23A 3fhjF-4gisA:
undetectable		 3fhjF-4gisA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.28A 3fi0A-4gisA:
undetectable		 3fi0A-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.26A 3fi0C-4gisA:
undetectable		 3fi0C-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.26A 3fi0D-4gisA:
undetectable		 3fi0D-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.29A 3fi0F-4gisA:
undetectable		 3fi0F-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.34A 3fi0H-4gisA:
undetectable		 3fi0H-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.26A 3fi0J-4gisA:
undetectable		 3fi0J-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.29A 3fi0L-4gisA:
undetectable		 3fi0L-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.24A 3fi0M-4gisA:
undetectable		 3fi0M-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.27A 3fi0O-4gisA:
undetectable		 3fi0O-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 9 GLY A 355
VAL A 123
HIS A 335
ILE A 353
GLN A 145
 None
 1.34A 3fi0R-4gisA:
undetectable		 3fi0R-4gisA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 12 GLY A  36
ASN A 320
GLY A  92
SER A  91
GLY A 286
 None
 1.05A 3huoB-4gisA:
undetectable		 3huoB-4gisA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 4 LEU A 258
GLY A 256
LEU A 255
GLU A 231
 None
None
None
MG  A 405 (-2.7A)
 0.94A 3tgvB-4gisA:
undetectable		 3tgvB-4gisA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 8 TYR A 181
TYR A 176
HIS A 397
LEU A 234
 None
 1.39A 3uzzB-4gisA:
3.4		 3uzzB-4gisA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 12 ALA A 317
GLN A 333
LEU A 323
THR A  23
PHE A 346
 None
 1.49A 3vhuA-4gisA:
undetectable		 3vhuA-4gisA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 12 GLY A 364
GLY A 366
GLU A 361
ALA A 105
LEU A 112
 None
 1.17A 3vywA-4gisA:
undetectable		 3vywA-4gisA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4gis ENOLASE
(Vibrio
harveyi) 		3 / 3 ARG A 151
TYR A 356
ASN A 324
 None
 0.96A 4ffwB-4gisA:
undetectable		 4ffwB-4gisA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 8 ASP A 179
GLN A 217
VAL A 186
THR A 185
 None
 1.02A 4lnwA-4gisA:
undetectable		 4lnwA-4gisA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 11 ARG A 371
GLY A 366
ILE A 100
THR A  23
ILE A 315
 None
 0.93A 4njvB-4gisA:
undetectable		 4njvB-4gisA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 11 ARG A 371
GLY A 366
ILE A 100
THR A  23
ILE A 315
 None
 0.97A 4njvC-4gisA:
undetectable		 4njvC-4gisA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 10 CYH A 279
CYH A 297
LEU A 293
ALA A 290
LEU A 323
 None
 1.26A 4p65A-4gisA:
undetectable
4p65B-4gisA:
undetectable
4p65F-4gisA:
undetectable
4p65H-4gisA:
undetectable		 4p65A-4gisA:
4.79
4p65B-4gisA:
6.94
4p65F-4gisA:
6.94
4p65H-4gisA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 4 ASN A 324
TRP A 306
LEU A 293
PHE A 276
 None
 1.40A 4u15B-4gisA:
0.0		 4u15B-4gisA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 4 ILE A   6
ASN A   8
ILE A  25
VAL A  24
 None
 1.27A 4uy87-4gisA:
undetectable		 4uy87-4gisA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 12 GLY A 316
LEU A  21
LEU A 323
GLY A 286
ILE A 287
 None
 1.01A 5d4uC-4gisA:
undetectable		 5d4uC-4gisA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 12 GLY A 316
LEU A  21
LEU A 323
GLY A 286
ILE A 287
 None
 0.98A 5d4uD-4gisA:
undetectable		 5d4uD-4gisA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 5 LEU A 203
PHE A 189
ILE A 230
ILE A 222
 None
 1.00A 5dzk4-4gisA:
undetectable
5dzkg-4gisA:
2.1
5dzkm-4gisA:
undetectable
5dzkn-4gisA:
undetectable		 5dzk4-4gisA:
2.44
5dzkg-4gisA:
20.47
5dzkm-4gisA:
18.27
5dzkn-4gisA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 4gis ENOLASE
(Vibrio
harveyi) 		3 / 3 ILE A  25
ILE A 100
MET A 369
 None
 0.65A 5i9yA-4gisA:
undetectable		 5i9yA-4gisA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 10 LEU A 143
LEU A 203
ALA A 127
LEU A 135
GLU A 144
 None
 1.14A 5y7pG-4gisA:
undetectable		 5y7pG-4gisA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4gis ENOLASE
(Vibrio
harveyi) 		4 / 5 ILE A 222
PHE A 218
ASN A 163
TYR A 157
 None
 1.17A 6a93B-4gisA:
undetectable		 6a93B-4gisA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4gis ENOLASE
(Vibrio
harveyi) 		5 / 11 ASP A  94
PRO A 289
PRO A 314
ALA A 317
PRO A 309
 None
None
None
None
GOL  A 404 (-4.3A)
 1.40A 6bm5A-4gisA:
undetectable		 6bm5A-4gisA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 4gis ENOLASE
(Vibrio
harveyi) 		3 / 3 ILE A  13
THR A  14
PRO A  44
 None
 0.62A 6ncsA-4gisA:
9.3		 6ncsA-4gisA:
20.42