SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4giw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  89
VAL A  91
TRP A 136
 None
 0.96A 1grmA-4giwA:
undetectable		 1grmA-4giwA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  89
VAL A  91
TRP A 136
 None
 0.96A 1grmB-4giwA:
undetectable		 1grmB-4giwA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A  97
SER A  99
SER A  90
LEU A 146
 None
 1.04A 1ibgL-4giwA:
undetectable		 1ibgL-4giwA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  89
VAL A  91
TRP A 136
 None
 0.91A 1magA-4giwA:
undetectable		 1magA-4giwA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  89
VAL A  91
TRP A 136
 None
 0.91A 1magB-4giwA:
undetectable		 1magB-4giwA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  23
LEU A 175
THR A  54
LEU A 128
ILE A  22
 None
 0.97A 1ra8A-4giwA:
undetectable		 1ra8A-4giwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  23
LEU A 175
THR A  54
LEU A 128
ILE A  22
 None
 0.94A 1rd7A-4giwA:
undetectable		 1rd7A-4giwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  23
LEU A 175
THR A  54
LEU A 128
ILE A  22
 None
 0.96A 1rd7B-4giwA:
undetectable		 1rd7B-4giwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  23
LEU A 175
THR A  54
LEU A 128
ILE A  22
 None
 0.95A 1rx7A-4giwA:
undetectable		 1rx7A-4giwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 185
LEU A 128
ASN A 129
LEU A 127
LEU A 175
 None
 1.21A 1zucB-4giwA:
undetectable		 1zucB-4giwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  23
LEU A 175
THR A  54
LEU A 128
ILE A  22
 None
 0.99A 2d0kB-4giwA:
undetectable		 2d0kB-4giwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 124
VAL A  86
LEU A 140
PHE A 157
ALA A  61
 None
 1.46A 2jj8C-4giwA:
undetectable		 2jj8C-4giwA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A  12
LEU A 175
ALA A  58
LEU A  59
PHE A 137
 None
 1.24A 2vcvD-4giwA:
undetectable		 2vcvD-4giwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 185
LEU A 133
LEU A  55
VAL A  51
PHE A 183
 None
 1.03A 2w9gA-4giwA:
undetectable		 2w9gA-4giwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 185
LEU A 133
LEU A  55
VAL A  51
PHE A 183
 None
 1.03A 2w9hA-4giwA:
undetectable		 2w9hA-4giwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 185
LEU A 128
ASN A 129
LEU A 127
LEU A 175
 None
 1.27A 3d90B-4giwA:
undetectable		 3d90B-4giwA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 185
LEU A 133
LEU A  55
VAL A  51
PHE A 183
 None
 1.00A 3frbX-4giwA:
undetectable		 3frbX-4giwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 117
HIS A 121
SER A 115
 None
 0.99A 4mjwA-4giwA:
undetectable
4mjwB-4giwA:
undetectable		 4mjwA-4giwA:
14.60
4mjwB-4giwA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 137
LEU A 140
SER A 168
VAL A  15
LEU A  12
 None
 1.43A 4wnvA-4giwA:
1.4		 4wnvA-4giwA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  23
LEU A 175
THR A  54
LEU A 128
ILE A  22
 None
 0.97A 4x5gB-4giwA:
undetectable		 4x5gB-4giwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 124
LEU A  50
LYS A  21
VAL A  15
 None
 1.14A 5jmnB-4giwA:
undetectable		 5jmnB-4giwA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 4 PHE A 120
LEU A 178
LEU A 127
VAL A  51
 None
 1.26A 5xxiA-4giwA:
undetectable		 5xxiA-4giwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  23
LEU A 175
THR A  54
LEU A 128
ILE A  22
 None
 0.92A 5z6jA-4giwA:
undetectable		 5z6jA-4giwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  67
GLU A  88
VAL A  86
THR A  76
GLY A  77
 None
 1.02A 6mn8A-4giwA:
undetectable		 6mn8A-4giwA:
15.77