SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4giz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 GLU A 131
GLU A 132
LEU A 136
MET A 225
LEU A 116
 None
 1.46A 1a29A-4gizA:
undetectable		 1a29A-4gizA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 6 VAL A   9
VAL A  51
ILE A  61
ASN A 268
 None
 0.93A 1e06A-4gizA:
undetectable		 1e06A-4gizA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4giz PROTEIN E6
(Alphapapillomavi
rus
9) 		5 / 12 TYR C  81
TRP C 132
GLY C 130
SER C  80
TYR C  92
 None
 1.40A 1nbhA-4gizC:
undetectable		 1nbhA-4gizC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4giz PROTEIN E6
(Alphapapillomavi
rus
9) 		5 / 12 TYR C  81
TRP C 132
GLY C 130
SER C  80
TYR C  92
 None
 1.40A 1nbhD-4gizC:
undetectable		 1nbhD-4gizC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY A 188
GLY A 166
GLY A 167
LEU A 362
ASP A 359
 None
 1.06A 1qzzA-4gizA:
undetectable		 1qzzA-4gizA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 10 LEU A 193
LEU A 196
ILE A 162
GLU A 154
LEU A 152
 None
None
None
CEY  A 400 (-3.1A)
None
 1.25A 1wopA-4gizA:
undetectable		 1wopA-4gizA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLY A 188
GLY A 166
GLY A 167
LEU A 362
ASP A 359
 None
 1.04A 1xdsA-4gizA:
undetectable		 1xdsA-4gizA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 ALA A 304
ILE A 109
VAL A  98
LEU A  77
ILE A  80
 None
 1.23A 2h42A-4gizA:
undetectable		 2h42A-4gizA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 263
ILE A 109
VAL A  98
LEU A  77
ILE A  80
 None
 0.97A 2h42C-4gizA:
undetectable		 2h42C-4gizA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.66A 3bjwC-4gizA:
undetectable		 3bjwC-4gizA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.82A 3bjwA-4gizA:
undetectable		 3bjwA-4gizA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 344
GLY A 188
ALA A 189
LEU A 193
LEU A 161
 None
 1.02A 3hs6A-4gizA:
undetectable		 3hs6A-4gizA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 GLU A 154
TYR A 156
MET A 331
TRP A 341
 CEY  A 400 (-3.1A)
CEY  A 400 (-3.7A)
CEY  A 400 ( 3.9A)
CEY  A 400 (-3.8A)
 0.83A 3jyrA-4gizA:
58.3		 3jyrA-4gizA:
91.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 11 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
 None
 1.17A 3mg0H-4gizA:
undetectable
3mg0I-4gizA:
undetectable		 3mg0H-4gizA:
21.15
3mg0I-4gizA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.02A 3n8yB-4gizA:
undetectable		 3n8yB-4gizA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VFJ_A_ACTA410_0
(MALTOSE-BINDING
PERIPLASMIC PROTEIN,
C-TERMINAL FUSED BY
CYS-LYS-D-ALA-D-ALA)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 4 LYS A  16
ALA A  64
GLU A 112
LEU A 263
 CEY  A 400 (-2.9A)
CEY  A 400 (-3.6A)
CEY  A 400 (-3.0A)
None
 0.85A 3vfjA-4gizA:
56.3		 3vfjA-4gizA:
96.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
PROTEIN E6
(Alphapapillomavi
rus
9;
Escherichia
coli;
Homo
sapiens) 		3 / 3 TYR A 342
ARG C 129
SER A 338
 CEY  A 400 (-4.5A)
None
None
 1.04A 4khpI-4gizA:
undetectable
4khpJ-4gizA:
undetectable		 4khpI-4gizA:
15.18
4khpJ-4gizA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.16A 4or0B-4gizA:
undetectable		 4or0B-4gizA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 MET A 337
TRP A 341
TYR A 172
GLU A 329
 None
CEY  A 400 (-3.8A)
None
None
 1.47A 4r87J-4gizA:
undetectable
4r87L-4gizA:
undetectable		 4r87J-4gizA:
18.23
4r87L-4gizA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
PROTEIN E6
(Alphapapillomavi
rus
9;
Escherichia
coli;
Homo
sapiens) 		4 / 4 ASN C 105
LEU A 379
PHE C  69
TYR C  32
 None
 1.49A 4u14A-4gizC:
undetectable		 4u14A-4gizC:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 LEU A  77
GLY A 266
ALA A 265
SER A 264
 None
 0.90A 5f1aB-4gizA:
undetectable		 5f1aB-4gizA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 4giz PROTEIN E6
(Alphapapillomavi
rus
9) 		3 / 3 TYR C  81
TYR C  92
GLN C  91
 None
 0.88A 5jsdA-4gizC:
undetectable
5jsdB-4gizC:
undetectable		 5jsdA-4gizC:
10.15
5jsdB-4gizC:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 4giz PROTEIN E6
(Alphapapillomavi
rus
9) 		3 / 3 TYR C  81
TYR C  92
GLN C  91
 None
 0.88A 5jsdB-4gizC:
undetectable
5jsdC-4gizC:
undetectable		 5jsdB-4gizC:
10.15
5jsdC-4gizC:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
 None
 1.21A 5l66H-4gizA:
undetectable
5l66I-4gizA:
undetectable		 5l66H-4gizA:
23.31
5l66I-4gizA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 GLN A  50
ALA A 270
GLY A  55
THR A  54
ALA A  53
 None
 1.21A 5l66V-4gizA:
undetectable
5l66W-4gizA:
undetectable		 5l66V-4gizA:
23.31
5l66W-4gizA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4giz PROTEIN E6
(Alphapapillomavi
rus
9) 		4 / 5 LEU C  67
CYH C 106
CYH C 136
ASP C  44
 None
ZN  C 201 (-2.3A)
ZN  C 201 (-2.2A)
None
 1.44A 5mafA-4gizC:
undetectable		 5mafA-4gizC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.95A 5sxqA-4gizA:
undetectable		 5sxqA-4gizA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.99A 5sxqB-4gizA:
undetectable		 5sxqB-4gizA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.98A 5sxtA-4gizA:
undetectable		 5sxtA-4gizA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.97A 5sxtB-4gizA:
undetectable		 5sxtB-4gizA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 8 VAL A 344
GLY A 192
LEU A 196
THR A 194
 None
 0.98A 5syjB-4gizA:
undetectable		 5syjB-4gizA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ALA A  64
GLY A 261
GLU A 112
ASN A  13
 CEY  A 400 (-3.6A)
None
CEY  A 400 (-3.0A)
CEY  A 400 (-3.7A)
 0.78A 5ybbB-4gizA:
undetectable		 5ybbB-4gizA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
(Escherichia
coli;
Homo
sapiens) 		5 / 12 LEU A 276
GLY A  25
VAL A  36
LEU A   8
ILE A  10
 None
 1.01A 6ecxA-4gizA:
undetectable		 6ecxA-4gizA:
22.28