SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gj1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 11 THR A   2
LEU A 241
LEU A 211
VAL A 184
VAL A 182
 None
 1.26A 3lxiB-4gj1A:
undetectable		 3lxiB-4gj1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		4 / 7 LEU A  50
GLY A  83
GLU A  89
ALA A  56
 None
 0.91A 3tehB-4gj1A:
undetectable		 3tehB-4gj1A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 10 THR A   2
LEU A 241
LEU A 211
VAL A 184
VAL A 182
 None
 1.27A 4c9nB-4gj1A:
undetectable		 4c9nB-4gj1A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 9 THR A   2
LEU A 241
LEU A 211
VAL A 184
VAL A 182
 None
 1.31A 4c9pA-4gj1A:
undetectable		 4c9pA-4gj1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		4 / 8 GLY A  83
GLY A 104
TYR A 160
LEU A 128
 None
 0.76A 4fgzB-4gj1A:
undetectable		 4fgzB-4gj1A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 12 LEU A 169
LEU A  53
ALA A  56
GLY A  81
GLY A  83
 None
 1.01A 4rn6B-4gj1A:
undetectable		 4rn6B-4gj1A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		3 / 3 LYS A 181
ARG A  17
VAL A  19
 None
 1.05A 4x3uA-4gj1A:
undetectable
4x3uB-4gj1A:
undetectable		 4x3uA-4gj1A:
13.22
4x3uB-4gj1A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 204
VAL A 205
THR A 171
VAL A 182
LEU A 214
 None
 1.20A 4yb6A-4gj1A:
undetectable
4yb6E-4gj1A:
undetectable		 4yb6A-4gj1A:
23.10
4yb6E-4gj1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 204
VAL A 205
THR A 171
VAL A 182
LEU A 214
 None
 1.20A 4yb6B-4gj1A:
undetectable
4yb6C-4gj1A:
undetectable		 4yb6B-4gj1A:
23.10
4yb6C-4gj1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 10 GLY A 204
VAL A 205
THR A 171
VAL A 182
LEU A 214
 None
 1.29A 4yb6C-4gj1A:
undetectable
4yb6F-4gj1A:
undetectable		 4yb6C-4gj1A:
23.10
4yb6F-4gj1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 10 LEU A 214
GLY A 204
VAL A 205
THR A 171
VAL A 182
 None
 1.29A 4yb6A-4gj1A:
undetectable
4yb6D-4gj1A:
undetectable		 4yb6A-4gj1A:
23.10
4yb6D-4gj1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 10 LEU A 214
GLY A 204
VAL A 205
THR A 171
VAL A 182
 None
 1.27A 4yb6D-4gj1A:
undetectable
4yb6E-4gj1A:
undetectable		 4yb6D-4gj1A:
23.10
4yb6E-4gj1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 10 LEU A 214
GLY A 204
VAL A 205
THR A 171
VAL A 182
 None
 1.18A 4yb6B-4gj1A:
undetectable
4yb6F-4gj1A:
undetectable		 4yb6B-4gj1A:
23.10
4yb6F-4gj1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		3 / 3 VAL A 234
TYR A  40
ALA A  43
 None
 0.54A 4ybnA-4gj1A:
undetectable		 4ybnA-4gj1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 11 ALA A  71
VAL A  98
LEU A  70
LEU A  10
VAL A  80
 None
 1.18A 5eb5A-4gj1A:
undetectable		 5eb5A-4gj1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		3 / 3 GLN A  63
THR A  54
ASP A  12
 None
 0.86A 5k9dA-4gj1A:
13.5		 5k9dA-4gj1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE
(Campylobacter
jejuni) 		5 / 12 VAL A 127
VAL A 102
GLY A 203
VAL A 205
PHE A 232
 None
 1.04A 6brdC-4gj1A:
undetectable		 6brdC-4gj1A:
18.52