SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 4gj4 SOLUBLE GUANYLYL
CYCLASE ALPHA-1
SUBUNIT
(Manduca
sexta) 		4 / 4 VAL A 281
LEU A 298
ILE A 341
LEU A 342
 None
 1.00A 2byoA-4gj4A:
undetectable		 2byoA-4gj4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4gj4 SOLUBLE GUANYLYL
CYCLASE ALPHA-1
SUBUNIT
(Manduca
sexta) 		4 / 7 PRO A 348
MET A 350
LYS A 368
GLY A 384
 None
 0.80A 2hs1B-4gj4A:
undetectable		 2hs1B-4gj4A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4gj4 SOLUBLE GUANYLYL
CYCLASE ALPHA-1
SUBUNIT
(Manduca
sexta) 		4 / 5 LEU A 303
GLY A 304
PHE A 307
PHE A 326
 None
 1.15A 3smtA-4gj4A:
undetectable		 3smtA-4gj4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_B_017B202_1
(PROTEASE)		 4gj4 SOLUBLE GUANYLYL
CYCLASE ALPHA-1
SUBUNIT
(Manduca
sexta) 		4 / 7 PRO A 348
MET A 350
LYS A 368
GLY A 384
 None
 0.82A 3ucbB-4gj4A:
undetectable		 3ucbB-4gj4A:
23.01