SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gjh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5
(Mus
musculus) 		5 / 12 LEU A 494
LEU A 434
VAL A 474
GLU A 480
LEU A 479
 None
 1.12A 2bxfA-4gjhA:
undetectable		 2bxfA-4gjhA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5
(Mus
musculus) 		4 / 6 HIS A 476
TYR A 410
GLY A 402
LYS A 403
 None
 1.12A 2i30A-4gjhA:
undetectable		 2i30A-4gjhA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5
(Mus
musculus) 		5 / 11 ARG A 429
GLN A 428
LEU A 500
PHE A 411
LEU A 432
 None
 1.39A 3jwqA-4gjhA:
undetectable
3jwqD-4gjhA:
undetectable		 3jwqA-4gjhA:
19.76
3jwqD-4gjhA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5
(Mus
musculus) 		3 / 3 PHE A 381
GLN A 344
PHE A 411
 None
 0.81A 3rv5A-4gjhA:
undetectable		 3rv5A-4gjhA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5
(Mus
musculus) 		4 / 7 HIS A 476
TYR A 410
GLY A 402
LYS A 403
 None
 0.96A 4z69A-4gjhA:
undetectable		 4z69A-4gjhA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 4gjh TNF
RECEPTOR-ASSOCIATED
FACTOR 5
(Mus
musculus) 		5 / 12 LEU A 354
GLY A 352
TYR A 388
PHE A 448
LEU A 432
 None
 1.33A 5kklB-4gjhA:
undetectable		 5kklB-4gjhA:
11.36