SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4gk5 DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 10 LEU E1171
LEU E1159
ILE E1232
THR E1177
ILE E1176
 None
 1.32A 1i18A-4gk5E:
undetectable
1i18B-4gk5E:
undetectable		 1i18A-4gk5E:
18.98
1i18B-4gk5E:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4gk5 DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 10 THR E1177
ILE E1176
LEU E1171
LEU E1159
ILE E1232
 None
 1.29A 1i18A-4gk5E:
undetectable
1i18B-4gk5E:
undetectable		 1i18A-4gk5E:
18.98
1i18B-4gk5E:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4gk5 DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 12 TYR E1193
THR E1195
CYH E1194
PRO E1157
VAL E1236
 None
 1.45A 1z9hA-4gk5E:
2.2		 1z9hA-4gk5E:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 4gk5 DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		5 / 12 TYR E1193
THR E1195
CYH E1194
PRO E1157
VAL E1236
 None
 1.45A 1z9hC-4gk5E:
2.6		 1z9hC-4gk5E:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 4gk5 DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 5 LEU E1203
VAL E1236
VAL E1250
TYR E1244
 None
 1.01A 4r7iA-4gk5E:
undetectable		 4r7iA-4gk5E:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4gk5 DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 ASP E1234
ASN E1226
GLN E1218
 None
 0.82A 5k7uA-4gk5E:
undetectable		 5k7uA-4gk5E:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4gk5 DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 4 VAL E1239
LEU E1240
LEU E1248
ASP E1207
 None
 1.48A 5xv7A-4gk5E:
undetectable		 5xv7A-4gk5E:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4gk5 DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		3 / 3 ASP E1207
LEU E1208
ARG E1215
 None
 0.82A 7dfrA-4gk5E:
undetectable		 7dfrA-4gk5E:
19.53