SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 6 HIS A   9
HIS A  11
HIS A 109
HIS A 154
ASP A 228
 ZN  A 303 (-3.3A)
ZN  A 303 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 303 ( 2.6A)
 1.00A 1fweC-4gk8A:
8.0		 1fweC-4gk8A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 GLU A  81
HIS A 109
HIS A   9
ASN A 195
ASP A 228
 ZN  A 301 (-2.5A)
ZN  A 301 ( 3.3A)
ZN  A 303 (-3.3A)
None
ZN  A 303 ( 2.6A)
 1.26A 1ituA-4gk8A:
7.7		 1ituA-4gk8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 ASN A 195
HIS A 109
TYR A 157
GLY A 153
 None
ZN  A 301 ( 3.3A)
GK8  A 305 (-4.6A)
None
 1.11A 1mxdA-4gk8A:
2.9		 1mxdA-4gk8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ASN A 195
HIS A 109
TYR A 157
GLY A 153
 None
ZN  A 301 ( 3.3A)
GK8  A 305 (-4.6A)
None
 1.15A 1mxgA-4gk8A:
5.3		 1mxgA-4gk8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 4 HIS A  42
GLU A  81
HIS A  11
HIS A 230
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.16A 1os2D-4gk8A:
undetectable		 1os2D-4gk8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 11 GLU A  41
ARG A 234
GLU A  20
ILE A  37
ASP A   7
 None
 1.42A 1t6zA-4gk8A:
undetectable		 1t6zA-4gk8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 11 TYR A   8
ARG A 234
GLU A  20
ILE A  37
ASP A   7
 None
 1.38A 1t6zB-4gk8A:
undetectable		 1t6zB-4gk8A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 4 HIS A  42
GLU A  81
HIS A  11
HIS A 230
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.12A 1utzA-4gk8A:
undetectable		 1utzA-4gk8A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 4 HIS A  42
GLU A  81
HIS A  11
HIS A 230
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.12A 1utzB-4gk8A:
undetectable		 1utzB-4gk8A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.12A 1v7zA-4gk8A:
undetectable		 1v7zA-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.12A 1v7zB-4gk8A:
undetectable		 1v7zB-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.12A 1v7zC-4gk8A:
undetectable		 1v7zC-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
 0.96A 1v7zD-4gk8A:
undetectable		 1v7zD-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
 0.96A 1v7zE-4gk8A:
undetectable		 1v7zE-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.12A 1v7zF-4gk8A:
undetectable		 1v7zF-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 PHE A 152
TYR A 135
TYR A 157
 None
None
GK8  A 305 (-4.6A)
 1.06A 1x70B-4gk8A:
undetectable		 1x70B-4gk8A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 SER A  12
PHE A  10
ARG A 234
GLU A  41
 None
 1.30A 2c8aA-4gk8A:
undetectable		 2c8aA-4gk8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 SER A  12
PHE A  10
ARG A 234
GLU A  41
 None
 1.21A 2c8aC-4gk8A:
undetectable		 2c8aC-4gk8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 ASP A  17
THR A  40
GLU A  41
GLU A  81
 ZN  A 302 ( 2.2A)
None
None
ZN  A 301 (-2.5A)
 1.44A 2dttB-4gk8A:
undetectable
2dttC-4gk8A:
undetectable		 2dttB-4gk8A:
19.71
2dttC-4gk8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 4 HIS A  42
GLU A  81
HIS A  11
HIS A 230
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.09A 2ow9B-4gk8A:
undetectable		 2ow9B-4gk8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 4 HIS A  42
GLU A  81
HIS A  11
HIS A 230
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.13A 2ozrC-4gk8A:
undetectable		 2ozrC-4gk8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 4 HIS A  42
GLU A  81
HIS A  11
HIS A 230
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.12A 2ozrD-4gk8A:
undetectable		 2ozrD-4gk8A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 HIS A   9
HIS A 230
ARG A 197
TYR A 157
 ZN  A 303 (-3.3A)
ZN  A 302 ( 3.3A)
GK8  A 305 (-3.3A)
GK8  A 305 (-4.6A)
 1.45A 2vmyA-4gk8A:
undetectable
2vmyB-4gk8A:
undetectable		 2vmyA-4gk8A:
20.53
2vmyB-4gk8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 THR A 204
GLU A 205
LYS A 248
ILE A 194
 None
 1.27A 2w98B-4gk8A:
undetectable		 2w98B-4gk8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 9 ILE A 194
ILE A 223
PHE A 215
ILE A 105
PHE A 257
 None
 1.46A 2ygpA-4gk8A:
undetectable		 2ygpA-4gk8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.12A 3a6jA-4gk8A:
undetectable		 3a6jA-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 7 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.11A 3a6jB-4gk8A:
undetectable		 3a6jB-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.10A 3a6jC-4gk8A:
undetectable		 3a6jC-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.13A 3a6jE-4gk8A:
undetectable		 3a6jE-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 8 GLU A  81
HIS A  11
ASP A 228
HIS A 154
HIS A  42
 ZN  A 301 (-2.5A)
ZN  A 303 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 302 ( 3.3A)
 1.09A 3a6jF-4gk8A:
undetectable		 3a6jF-4gk8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 SER A 151
ILE A 262
ASP A 263
ALA A 255
ILE A 223
 None
 1.03A 3ddyA-4gk8A:
undetectable		 3ddyA-4gk8A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HTH_A_PRLA201_0
(EBRA REPRESSOR)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 9 PHE A 152
VAL A 143
LEU A 136
TYR A 208
ASP A 156
 None
 1.15A 3hthA-4gk8A:
0.7		 3hthA-4gk8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 5 HIS A  11
SER A 229
ARG A 243
THR A  40
 ZN  A 303 ( 3.3A)
None
CL  A 306 ( 4.8A)
None
 1.41A 3okxA-4gk8A:
undetectable		 3okxA-4gk8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 5 HIS A  11
SER A 229
ARG A 243
THR A  40
 ZN  A 303 ( 3.3A)
None
CL  A 306 ( 4.8A)
None
 1.34A 3okxB-4gk8A:
undetectable		 3okxB-4gk8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 HIS A 154
HIS A   9
ILE A 105
 ZN  A 301 ( 3.3A)
ZN  A 303 (-3.3A)
None
 0.60A 3u52A-4gk8A:
undetectable
3u52C-4gk8A:
undetectable		 3u52A-4gk8A:
21.28
3u52C-4gk8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 5 THR A 256
ASP A 263
LYS A  75
GLU A  36
 None
 1.08A 3v5vC-4gk8A:
undetectable
3v5vD-4gk8A:
1.1		 3v5vC-4gk8A:
20.58
3v5vD-4gk8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5V_C_ACTC510_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 5 THR A 256
ASP A 263
LYS A  77
GLU A  36
 None
 1.13A 3v5vC-4gk8A:
undetectable
3v5vD-4gk8A:
1.1		 3v5vC-4gk8A:
20.58
3v5vD-4gk8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 5 LYS A  75
GLU A  36
THR A 256
ASP A 263
 None
 1.12A 4e7cA-4gk8A:
1.1
4e7cB-4gk8A:
1.1		 4e7cA-4gk8A:
20.58
4e7cB-4gk8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_B_ACTB502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 5 LYS A  77
GLU A  36
THR A 256
ASP A 263
 None
 1.14A 4e7cA-4gk8A:
1.1
4e7cB-4gk8A:
1.1		 4e7cA-4gk8A:
20.58
4e7cB-4gk8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 8 HIS A 154
ASP A 228
HIS A 109
HIS A  11
 ZN  A 301 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 303 ( 3.3A)
 0.91A 4exsB-4gk8A:
undetectable		 4exsB-4gk8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 HIS A  42
GLU A  81
ARG A 160
HIS A 109
TYR A 161
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
GK8  A 305 (-3.0A)
ZN  A 301 ( 3.3A)
None
 0.79A 4jd1A-4gk8A:
undetectable
4jd1B-4gk8A:
undetectable		 4jd1A-4gk8A:
21.99
4jd1B-4gk8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 HIS A 109
TYR A 161
HIS A  42
GLU A  81
ARG A 160
 ZN  A 301 ( 3.3A)
None
ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
GK8  A 305 (-3.0A)
 0.94A 4jd1A-4gk8A:
undetectable
4jd1B-4gk8A:
undetectable		 4jd1A-4gk8A:
21.99
4jd1B-4gk8A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 HIS A  42
GLU A  81
ARG A 160
HIS A 109
TYR A 161
 ZN  A 302 ( 3.3A)
ZN  A 301 (-2.5A)
GK8  A 305 (-3.0A)
ZN  A 301 ( 3.3A)
None
 0.88A 4jh3A-4gk8A:
undetectable
4jh3B-4gk8A:
undetectable		 4jh3A-4gk8A:
19.01
4jh3B-4gk8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 HIS A 109
HIS A 154
HIS A   9
HIS A  11
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 303 (-3.3A)
ZN  A 303 ( 3.3A)
 0.92A 4p6sA-4gk8A:
undetectable		 4p6sA-4gk8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 HIS A 109
HIS A 154
HIS A   9
HIS A  11
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 303 (-3.3A)
ZN  A 303 ( 3.3A)
 0.88A 4p6sB-4gk8A:
undetectable		 4p6sB-4gk8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 MET A  50
MET A  82
TYR A 117
 GK8  A 305 ( 3.9A)
None
GK8  A 305 ( 3.9A)
 1.44A 4p6xI-4gk8A:
undetectable		 4p6xI-4gk8A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 ILE A 223
LEU A 185
ALA A 186
LEU A 211
ILE A 194
 None
 0.94A 4pssA-4gk8A:
undetectable		 4pssA-4gk8A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.39A 5a06A-4gk8A:
2.0		 5a06A-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.41A 5a06C-4gk8A:
2.0		 5a06C-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.40A 5a06D-4gk8A:
undetectable		 5a06D-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.40A 5a06E-4gk8A:
undetectable		 5a06E-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 ARG A 160
PHE A  52
ASP A  17
TYR A 157
 GK8  A 305 (-3.0A)
None
ZN  A 302 ( 2.2A)
GK8  A 305 (-4.6A)
 1.38A 5a06F-4gk8A:
undetectable		 5a06F-4gk8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 8 HIS A 154
ASP A 228
HIS A 109
HIS A  11
 ZN  A 301 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 303 ( 3.3A)
 0.85A 5a5zA-4gk8A:
undetectable		 5a5zA-4gk8A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 11 HIS A 154
ASP A 228
HIS A 109
HIS A  11
GLU A  41
 ZN  A 301 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 301 ( 3.3A)
ZN  A 303 ( 3.3A)
None
 1.06A 5ayaA-4gk8A:
undetectable		 5ayaA-4gk8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		5 / 12 ALA A 249
ILE A 169
TYR A 208
ILE A 194
LEU A 178
 None
 1.00A 5h8tA-4gk8A:
undetectable		 5h8tA-4gk8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 VAL A 143
LEU A 185
CYH A 139
LEU A 155
 None
 1.16A 5hrqB-4gk8A:
undetectable
5hrqI-4gk8A:
undetectable
5hrqJ-4gk8A:
undetectable		 5hrqB-4gk8A:
9.74
5hrqI-4gk8A:
9.86
5hrqJ-4gk8A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 HIS A 109
HIS A 154
HIS A   9
HIS A  11
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 303 (-3.3A)
ZN  A 303 ( 3.3A)
 0.88A 5i3aA-4gk8A:
undetectable		 5i3aA-4gk8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 HIS A 109
HIS A 154
HIS A   9
HIS A  11
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 303 (-3.3A)
ZN  A 303 ( 3.3A)
 0.88A 5i3aB-4gk8A:
undetectable		 5i3aB-4gk8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 7 HIS A 109
HIS A 154
HIS A   9
HIS A  11
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 303 (-3.3A)
ZN  A 303 ( 3.3A)
 0.92A 5i3bA-4gk8A:
undetectable		 5i3bA-4gk8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 ASP A  17
HIS A  11
ILE A 231
TYR A 161
 ZN  A 302 ( 2.2A)
ZN  A 303 ( 3.3A)
None
None
 0.99A 5ih0A-4gk8A:
undetectable		 5ih0A-4gk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 ASP A 228
HIS A   9
ILE A 194
TYR A 135
 ZN  A 303 ( 2.6A)
ZN  A 303 (-3.3A)
None
None
 1.12A 5ih0A-4gk8A:
undetectable		 5ih0A-4gk8A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 ASP A 228
HIS A  11
HIS A 230
HIS A 154
 ZN  A 303 ( 2.6A)
ZN  A 303 ( 3.3A)
ZN  A 302 ( 3.3A)
ZN  A 301 ( 3.3A)
 0.92A 5ncdA-4gk8A:
3.6
5ncdD-4gk8A:
4.5		 5ncdA-4gk8A:
22.77
5ncdD-4gk8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 HIS A 109
ASP A 228
HIS A  11
HIS A 154
 ZN  A 301 ( 3.3A)
ZN  A 303 ( 2.6A)
ZN  A 303 ( 3.3A)
ZN  A 301 ( 3.3A)
 0.89A 5ncdB-4gk8A:
3.8
5ncdC-4gk8A:
3.6		 5ncdB-4gk8A:
22.77
5ncdC-4gk8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		4 / 6 ASP A 228
HIS A  11
HIS A 154
HIS A 109
 ZN  A 303 ( 2.6A)
ZN  A 303 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
 0.88A 5nelA-4gk8A:
4.5
5nelD-4gk8A:
3.9		 5nelA-4gk8A:
22.77
5nelD-4gk8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 HIS A 230
ASP A  17
HIS A  42
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
 0.57A 5oexA-4gk8A:
undetectable		 5oexA-4gk8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 HIS A 230
ASP A  17
HIS A  42
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
 0.56A 5oexB-4gk8A:
undetectable		 5oexB-4gk8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 HIS A 230
ASP A  17
HIS A  42
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
 0.55A 5oexC-4gk8A:
undetectable		 5oexC-4gk8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4gk8 HISTIDINOL-PHOSPHATA
SE
(Lactococcus
lactis) 		3 / 3 HIS A 230
ASP A  17
HIS A  42
 ZN  A 302 ( 3.3A)
ZN  A 302 ( 2.2A)
ZN  A 302 ( 3.3A)
 0.54A 5oexD-4gk8A:
undetectable		 5oexD-4gk8A:
19.52