SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4gkg C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		3 / 3 LEU A 369
ARG A 370
ARG A 373
 None
 0.96A 4yiaB-4gkgA:
undetectable		 4yiaB-4gkgA:
31.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4gkg C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		3 / 3 ARG A 355
HIS A 348
ARG A 352
 None
 0.92A 5iaoC-4gkgA:
undetectable		 5iaoC-4gkgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4gkg C4-DICARBOXYLATE
TRANSPORT SENSOR
PROTEIN DCTB
(Sinorhizobium
meliloti) 		3 / 3 ARG A 355
HIS A 348
ARG A 352
 None
 0.89A 5iaoF-4gkgA:
undetectable		 5iaoF-4gkgA:
19.18