SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 8 GLU A 231
ASP A 234
ARG A 237
MET A 238
 None
 1.11A 1dtlA-4gklA:
undetectable		 1dtlA-4gklA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ALA A 275
VAL A 280
TRP A 353
 None
 0.98A 1gmkA-4gklA:
undetectable
1gmkB-4gklA:
undetectable		 1gmkA-4gklA:
4.47
1gmkB-4gklA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ALA A 275
VAL A 280
TRP A 353
 None
 1.00A 1gmkC-4gklA:
undetectable
1gmkD-4gklA:
undetectable		 1gmkC-4gklA:
4.47
1gmkD-4gklA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.28A 1v54A-4gklA:
undetectable
1v54C-4gklA:
undetectable		 1v54A-4gklA:
21.23
1v54C-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.26A 1v54N-4gklA:
undetectable
1v54P-4gklA:
undetectable		 1v54N-4gklA:
21.23
1v54P-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.25A 1v55A-4gklA:
undetectable
1v55C-4gklA:
undetectable		 1v55A-4gklA:
21.23
1v55C-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 6 MET A  99
VAL A 100
LEU A 101
PHE A 139
 None
 1.14A 1x8vA-4gklA:
undetectable		 1x8vA-4gklA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.29A 2dyrA-4gklA:
undetectable
2dyrC-4gklA:
undetectable		 2dyrA-4gklA:
21.23
2dyrC-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.26A 2dyrN-4gklA:
undetectable
2dyrP-4gklA:
undetectable		 2dyrN-4gklA:
21.23
2dyrP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.25A 2eijA-4gklA:
undetectable
2eijC-4gklA:
undetectable		 2eijA-4gklA:
21.23
2eijC-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.22A 2eijN-4gklA:
undetectable
2eijP-4gklA:
undetectable		 2eijN-4gklA:
21.23
2eijP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.25A 2eikA-4gklA:
undetectable
2eikC-4gklA:
undetectable		 2eikA-4gklA:
21.23
2eikC-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.22A 2eikN-4gklA:
undetectable
2eikP-4gklA:
undetectable		 2eikN-4gklA:
21.23
2eikP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.26A 2eilA-4gklA:
undetectable
2eilC-4gklA:
undetectable		 2eilA-4gklA:
21.23
2eilC-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.23A 2eilN-4gklA:
undetectable
2eilP-4gklA:
undetectable		 2eilN-4gklA:
21.23
2eilP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		5 / 10 GLY A  54
GLY A  51
THR A  50
ALA A  64
ALA A 105
 None
 0.96A 2ej3B-4gklA:
undetectable		 2ej3B-4gklA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 ARG A 267
GLU A 413
PRO A 414
ALA A 275
 None
 1.33A 2ejgA-4gklA:
undetectable		 2ejgA-4gklA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 6 TYR A 232
TRP A 273
TYR A 216
ILE A 223
 None
 1.34A 2pgzD-4gklA:
undetectable
2pgzE-4gklA:
undetectable		 2pgzD-4gklA:
19.80
2pgzE-4gklA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.23A 3abkA-4gklA:
undetectable
3abkC-4gklA:
undetectable		 3abkA-4gklA:
21.23
3abkC-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.27A 3abmN-4gklA:
undetectable
3abmP-4gklA:
undetectable		 3abmN-4gklA:
21.23
3abmP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.25A 3ag2A-4gklA:
undetectable
3ag2C-4gklA:
undetectable		 3ag2A-4gklA:
21.23
3ag2C-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.25A 3ag2N-4gklA:
undetectable
3ag2P-4gklA:
undetectable		 3ag2N-4gklA:
21.23
3ag2P-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.22A 3ag3A-4gklA:
undetectable
3ag3C-4gklA:
undetectable		 3ag3A-4gklA:
21.23
3ag3C-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.20A 3ag3N-4gklA:
undetectable
3ag3P-4gklA:
undetectable		 3ag3N-4gklA:
21.23
3ag3P-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.22A 3ag4A-4gklA:
undetectable
3ag4C-4gklA:
undetectable		 3ag4A-4gklA:
21.23
3ag4C-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.23A 3ag4N-4gklA:
undetectable
3ag4P-4gklA:
undetectable		 3ag4N-4gklA:
21.23
3ag4P-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		5 / 9 ASP A  72
ILE A  47
ILE A 300
VAL A 100
ILE A  65
 None
 1.31A 3ekyB-4gklA:
undetectable		 3ekyB-4gklA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 5 TYR A 243
GLN A 239
ILE A 233
LEU A 236
 None
 1.25A 3ls4L-4gklA:
undetectable		 3ls4L-4gklA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 8 GLU A 291
TYR A 304
ARG A  33
ASP A  30
 None
 1.16A 3mjrD-4gklA:
undetectable		 3mjrD-4gklA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 VAL A 348
VAL A 363
LEU A 415
VAL A 399
 None
 1.08A 4e1gB-4gklA:
undetectable		 4e1gB-4gklA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ASP A 138
ARG A 128
ASP A 169
 None
 0.88A 4fp9D-4gklA:
undetectable		 4fp9D-4gklA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ARG A 347
GLU A 369
ASN A 365
 None
 0.81A 4imaD-4gklA:
4.6		 4imaD-4gklA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ARG A 347
GLU A 369
ASN A 365
 None
 0.82A 4ip7D-4gklA:
6.9		 4ip7D-4gklA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ILE A 274
MET A  37
ARG A 320
 None
 0.82A 4lnwA-4gklA:
undetectable		 4lnwA-4gklA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ILE A 315
MET A  37
ARG A 320
 None
 0.93A 4lnwA-4gklA:
undetectable		 4lnwA-4gklA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ILE A 274
MET A  37
ARG A 320
 None
 0.82A 4lnxA-4gklA:
undetectable		 4lnxA-4gklA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ILE A 315
MET A  37
ARG A 320
 None
 0.90A 4lnxA-4gklA:
undetectable		 4lnxA-4gklA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		5 / 12 VAL A 100
LEU A 173
TYR A 141
GLY A 172
ALA A 171
 None
 1.10A 4otyA-4gklA:
undetectable		 4otyA-4gklA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		5 / 12 VAL A 100
LEU A 173
TYR A 141
GLY A 172
ALA A 171
 None
 1.06A 4rrwC-4gklA:
undetectable		 4rrwC-4gklA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		5 / 12 VAL A 100
LEU A 173
TYR A 141
GLY A 172
ALA A 171
 None
 1.06A 4rrwD-4gklA:
undetectable		 4rrwD-4gklA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		5 / 12 VAL A 100
LEU A 173
TYR A 141
GLY A 172
ALA A 171
 None
 1.06A 4rrzC-4gklA:
undetectable		 4rrzC-4gklA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		5 / 12 VAL A 100
LEU A 173
TYR A 141
GLY A 172
ALA A 171
 None
 1.06A 4rrzD-4gklA:
undetectable		 4rrzD-4gklA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.46A 4v2yA-4gklA:
undetectable		 4v2yA-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.46A 4v2yB-4gklA:
undetectable		 4v2yB-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.45A 4v2zA-4gklA:
undetectable		 4v2zA-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 8 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.45A 4v2zB-4gklA:
undetectable		 4v2zB-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.47A 4v30A-4gklA:
undetectable		 4v30A-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.44A 5amhA-4gklA:
undetectable		 5amhA-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.46A 5amiA-4gklA:
undetectable		 5amiA-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.48A 5amjA-4gklA:
undetectable		 5amjA-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.46A 5amjB-4gklA:
undetectable		 5amjB-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.23A 5b1aN-4gklA:
undetectable
5b1aP-4gklA:
undetectable		 5b1aN-4gklA:
21.23
5b1aP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.22A 5b1bN-4gklA:
undetectable
5b1bP-4gklA:
undetectable		 5b1bN-4gklA:
21.23
5b1bP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 8 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.22A 5b3sA-4gklA:
undetectable
5b3sC-4gklA:
undetectable
5b3sP-4gklA:
undetectable		 5b3sA-4gklA:
21.23
5b3sC-4gklA:
18.87
5b3sP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.24A 5iy5A-4gklA:
undetectable
5iy5C-4gklA:
undetectable		 5iy5A-4gklA:
21.23
5iy5C-4gklA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ASP A 214
ASN A 255
GLN A 258
 None
 0.77A 5k7uA-4gklA:
undetectable		 5k7uA-4gklA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.46A 5oh1A-4gklA:
undetectable		 5oh1A-4gklA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.43A 5oh1B-4gklA:
undetectable		 5oh1B-4gklA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 PRO A 284
PHE A 278
TRP A 353
TYR A 351
 None
 1.46A 5oh3A-4gklA:
undetectable		 5oh3A-4gklA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 8 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.22A 5z85A-4gklA:
undetectable
5z85C-4gklA:
undetectable
5z85P-4gklA:
undetectable		 5z85A-4gklA:
21.23
5z85C-4gklA:
18.87
5z85P-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 8 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.22A 5zcpA-4gklA:
undetectable
5zcpC-4gklA:
undetectable
5zcpP-4gklA:
undetectable		 5zcpA-4gklA:
21.23
5zcpC-4gklA:
18.87
5zcpP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.24A 5zcqN-4gklA:
undetectable
5zcqP-4gklA:
undetectable		 5zcqN-4gklA:
21.23
5zcqP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ASP A 138
ARG A 128
ASP A 169
 None
 0.77A 5zvgA-4gklA:
undetectable		 5zvgA-4gklA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		3 / 3 ASP A 138
ARG A 128
ASP A 169
 None
 0.79A 5zvgB-4gklA:
undetectable		 5zvgB-4gklA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.19A 6nmfN-4gklA:
undetectable
6nmfP-4gklA:
undetectable		 6nmfN-4gklA:
21.23
6nmfP-4gklA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4gkl ALPHA-AMYLASE
(Thermotoga
neapolitana) 		4 / 7 TRP A 179
ASP A 212
THR A 198
TRP A 194
 None
 1.23A 6nmpN-4gklA:
undetectable
6nmpP-4gklA:
undetectable		 6nmpN-4gklA:
21.23
6nmpP-4gklA:
18.87