SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3
([Candida]
glabrata) 		3 / 3 ASN A 447
ASN A 409
ARG A 356
 None
None
ADP  A 702 (-3.3A)
 0.69A 2rlcA-4gkrA:
undetectable		 2rlcA-4gkrA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3
([Candida]
glabrata) 		6 / 12 VAL A 588
LEU A 587
ILE A 584
SER A 650
SER A 655
THR A 657
 None
 1.38A 3bjwF-4gkrA:
undetectable		 3bjwF-4gkrA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3
([Candida]
glabrata) 		5 / 12 ASN A 613
ALA A 591
SER A 560
GLN A 436
ARG A 561
 None
 1.34A 4ejwA-4gkrA:
undetectable		 4ejwA-4gkrA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3
([Candida]
glabrata) 		4 / 7 VAL A 373
ILE A 357
ARG A 356
ILE A 663
 None
None
ADP  A 702 (-3.3A)
None
 0.77A 4lv9B-4gkrA:
undetectable		 4lv9B-4gkrA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3
([Candida]
glabrata) 		5 / 10 VAL A 453
THR A 456
ILE A 457
LEU A 531
PHE A 566
 None
 1.07A 5mxbA-4gkrA:
undetectable		 5mxbA-4gkrA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4gkr NECK AND C-TERMINAL
MOTOR DOMAIN OF KAR3
([Candida]
glabrata) 		5 / 12 SER A 650
PHE A 432
LEU A 616
LEU A 590
VAL A 588
 None
 1.06A 5tudA-4gkrA:
undetectable		 5tudA-4gkrA:
21.98