SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		5 / 12 ALA A 203
GLY A 148
ILE A 205
ASP A 142
TYR A 176
 None
 1.03A 1x1aA-4gkyA:
undetectable		 1x1aA-4gkyA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		4 / 4 PHE A  52
LYS A  53
ILE A  80
THR A  95
 None
 1.42A 3ia4B-4gkyA:
undetectable		 3ia4B-4gkyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		4 / 5 TRP A  94
GLY A 148
ALA A 124
PHE A 262
 None
 1.11A 3wqwA-4gkyA:
undetectable		 3wqwA-4gkyA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		3 / 3 TYR A 208
THR A 211
THR A 206
 None
 0.82A 5aoxB-4gkyA:
undetectable		 5aoxB-4gkyA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		3 / 3 TYR A 208
THR A 211
THR A 206
 None
 0.78A 5aoxE-4gkyA:
undetectable		 5aoxE-4gkyA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		5 / 12 GLY A 245
LEU A 133
GLY A 148
ILE A 149
GLY A 135
 None
 0.99A 5d4uC-4gkyA:
undetectable		 5d4uC-4gkyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		5 / 12 GLY A 245
LEU A 133
GLY A 148
ILE A 149
GLY A 135
 None
 1.01A 5d4uD-4gkyA:
undetectable		 5d4uD-4gkyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		3 / 3 VAL A 108
HIS A 257
VAL A  82
 None
 0.65A 5jmnC-4gkyA:
undetectable		 5jmnC-4gkyA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4gky PROTEIN ERGIC-53
(Homo
sapiens) 		4 / 8 ILE A 125
VAL A 147
ALA A 231
LEU A 212
 None
 0.74A 5og9A-4gkyA:
undetectable		 5og9A-4gkyA:
20.22