SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ASN A 274
ILE A  46
PRO A  48
PHE A  54
TYR A  64
 None
None
PG4  A 502 (-4.4A)
None
PG4  A 502 ( 4.0A)
 1.03A 1g60B-4gl0A:
undetectable		 1g60B-4gl0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASP A 193
LEU A 187
LEU A 184
 None
 0.80A 1np1B-4gl0A:
undetectable		 1np1B-4gl0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  86
ALA A 272
LYS A 280
LEU A 111
PRO A 112
 None
 0.91A 2d0kA-4gl0A:
undetectable		 2d0kA-4gl0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 182
LEU A 141
GLY A 142
MET A 209
ALA A 160
 None
 1.14A 2oz7A-4gl0A:
undetectable		 2oz7A-4gl0A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 11 ILE A 170
ALA A 233
THR A 235
ARG A 177
LEU A 141
 None
 1.37A 2v0mD-4gl0A:
undetectable		 2v0mD-4gl0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  46
LEU A  37
PHE A  54
ILE A 282
ASN A 283
 None
 1.05A 2w3bB-4gl0A:
undetectable		 2w3bB-4gl0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  46
LEU A  37
PHE A  54
ILE A 282
ASN A 283
 None
 1.05A 2w3mA-4gl0A:
undetectable		 2w3mA-4gl0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 10 TRP A 158
LEU A 182
VAL A 234
GLY A 142
THR A 157
 None
 1.29A 2wd9C-4gl0A:
undetectable		 2wd9C-4gl0A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ASN A 283
ASN A 290
GLU A  57
 None
 0.93A 3kpdC-4gl0A:
undetectable		 3kpdC-4gl0A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A  46
LEU A  37
PHE A  54
ILE A 282
ASN A 283
 None
 1.06A 4kebB-4gl0A:
undetectable		 4kebB-4gl0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		4 / 6 LYS A 110
LEU A 111
ASN A 113
PRO A 112
 None
 1.13A 4yv5B-4gl0A:
undetectable		 4yv5B-4gl0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		4 / 6 LYS A 110
LEU A 111
ASN A 113
PRO A 112
 None
 1.13A 4yv5A-4gl0A:
undetectable		 4yv5A-4gl0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 250
ASP A 156
PHE A 155
THR A 157
TYR A 252
 None
 1.49A 5d0yB-4gl0A:
undetectable		 5d0yB-4gl0A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		3 / 3 LEU A  50
PHE A 281
ILE A  46
 None
 0.66A 5dzk1-4gl0A:
undetectable
5dzkF-4gl0A:
undetectable
5dzkM-4gl0A:
undetectable		 5dzk1-4gl0A:
2.53
5dzkF-4gl0A:
22.52
5dzkM-4gl0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		4 / 5 LEU A  50
PHE A 281
ILE A  51
ILE A  39
 None
None
PG4  A 502 ( 4.3A)
None
 1.00A 5dzk4-4gl0A:
undetectable
5dzkg-4gl0A:
undetectable
5dzkm-4gl0A:
undetectable
5dzkn-4gl0A:
undetectable		 5dzk4-4gl0A:
2.53
5dzkg-4gl0A:
22.52
5dzkm-4gl0A:
22.12
5dzkn-4gl0A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		4 / 6 ILE A 143
VAL A 234
TRP A 158
SER A 259
 None
 0.98A 5jwaH-4gl0A:
undetectable		 5jwaH-4gl0A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PHE A 236
SER A 237
ASN A 185
ASP A 257
 PGE  A 501 (-3.5A)
None
EDO  A 507 ( 4.7A)
None
 1.47A 5kpcA-4gl0A:
undetectable		 5kpcA-4gl0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A  37
ALA A 278
PHE A 281
TYR A  40
LEU A 102
 None
 1.35A 5ljbA-4gl0A:
undetectable		 5ljbA-4gl0A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 4gl0 LMO0810 PROTEIN
(Listeria
monocytogenes) 		5 / 10 TYR A 344
PHE A 349
LEU A 206
ALA A 202
LEU A 184
 PG4  A 503 (-3.7A)
None
None
None
None
 1.17A 5y7pG-4gl0A:
undetectable		 5y7pG-4gl0A:
22.70