SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 422
VAL A 366
VAL A 453
ILE A 416
 None
C  D   8 ( 3.9A)
None
G  D   9 ( 4.4A)
 1.15A 2hyyB-4gl2A:
undetectable		 2hyyB-4gl2A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 CYH A 328
SER A 490
TYR A 855
VAL A 861
LEU A 528
 None
 1.42A 2prgB-4gl2A:
undetectable		 2prgB-4gl2A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 572
PHE A 573
LEU A 611
 None
 0.29A 2zi9A-4gl2A:
2.5		 2zi9A-4gl2A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ILE A 484
TYR A 454
ILE A 441
HIS A 346
 None
 1.08A 3eteA-4gl2A:
undetectable
3eteE-4gl2A:
undetectable		 3eteA-4gl2A:
22.27
3eteE-4gl2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 484
TYR A 454
ILE A 441
HIS A 346
 None
 1.06A 3eteB-4gl2A:
undetectable
3eteC-4gl2A:
undetectable		 3eteB-4gl2A:
22.27
3eteC-4gl2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A 441
HIS A 346
ILE A 484
TYR A 454
 None
 1.07A 3eteD-4gl2A:
undetectable
3eteF-4gl2A:
undetectable		 3eteD-4gl2A:
22.27
3eteF-4gl2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 422
VAL A 366
VAL A 453
ILE A 416
 None
C  D   8 ( 3.9A)
None
G  D   9 ( 4.4A)
 1.18A 3k5vA-4gl2A:
undetectable		 3k5vA-4gl2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 422
VAL A 366
VAL A 453
ILE A 416
 None
C  D   8 ( 3.9A)
None
G  D   9 ( 4.4A)
 1.22A 3k5vB-4gl2A:
undetectable		 3k5vB-4gl2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A 512
ILE A 326
THR A 488
ILE A 858
ILE A 506
 None
 1.12A 3kpbA-4gl2A:
undetectable		 3kpbA-4gl2A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 CYH A 328
THR A 488
ILE A 814
LEU A 509
ILE A 858
 None
 1.29A 3sp9A-4gl2A:
undetectable		 3sp9A-4gl2A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A 488
HIS A 447
ASN A 364
TYR A 454
 None
 1.26A 4awuA-4gl2A:
undetectable		 4awuA-4gl2A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 809
ARG A 806
ILE A 814
ASN A 364
 None
 1.37A 4i00A-4gl2A:
undetectable		 4i00A-4gl2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 454
ILE A 814
LEU A 513
LEU A 509
 None
 0.84A 4l1wA-4gl2A:
undetectable		 4l1wA-4gl2A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 487
VAL A 338
LEU A 368
LEU A 372
 None
 0.96A 4l1xA-4gl2A:
undetectable		 4l1xA-4gl2A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLY A 795
ILE A 775
LYS A 772
GLN A 771
 None
None
None
G  D   7 ( 4.0A)
 1.14A 4ma8C-4gl2A:
undetectable		 4ma8C-4gl2A:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 ILE A 557
HIS A 603
LEU A 604
LEU A 676
LEU A 626
 None
 0.95A 4p65E-4gl2A:
undetectable
4p65F-4gl2A:
undetectable
4p65J-4gl2A:
undetectable
4p65L-4gl2A:
undetectable		 4p65E-4gl2A:
3.31
4p65F-4gl2A:
4.67
4p65J-4gl2A:
4.67
4p65L-4gl2A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 676
LEU A 626
ILE A 557
HIS A 603
LEU A 604
 None
 0.79A 4p65B-4gl2A:
undetectable
4p65D-4gl2A:
undetectable
4p65I-4gl2A:
undetectable
4p65J-4gl2A:
undetectable		 4p65B-4gl2A:
4.67
4p65D-4gl2A:
4.67
4p65I-4gl2A:
3.31
4p65J-4gl2A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 626
LEU A 676
ILE A 557
HIS A 603
LEU A 604
 None
 0.79A 4p65F-4gl2A:
undetectable
4p65H-4gl2A:
undetectable
4p65K-4gl2A:
undetectable
4p65L-4gl2A:
undetectable		 4p65F-4gl2A:
4.67
4p65H-4gl2A:
4.67
4p65K-4gl2A:
3.31
4p65L-4gl2A:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 SER A 911
ALA A 589
ASP A 673
GLU A 633
GLU A 602
 None
 1.33A 4zjoA-4gl2A:
undetectable		 4zjoA-4gl2A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 461
ASP A 514
ILE A 881
ILE A 873
 None
 0.99A 5hw8H-4gl2A:
undetectable		 5hw8H-4gl2A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 372
VAL A 340
PHE A 377
TYR A 454
GLY A 486
 None
 1.49A 5i8fA-4gl2A:
undetectable		 5i8fA-4gl2A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLU A 602
CYH A 962
CYH A 964
PHE A 987
 None
ZN  A1102 (-2.3A)
ZN  A1102 (-2.1A)
None
 1.41A 5oajD-4gl2A:
undetectable
5oajE-4gl2A:
undetectable		 5oajD-4gl2A:
15.68
5oajE-4gl2A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 350
LYS A 358
SER A 438
 None
 1.47A 5odiA-4gl2A:
undetectable		 5odiA-4gl2A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 627
ASN A 631
ASN A 684
TYR A 630
PHE A 629
 None
 1.43A 5v37A-4gl2A:
2.3		 5v37A-4gl2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 680
ILE A 557
PRO A 549
PHE A 550
 None
 1.15A 5x23A-4gl2A:
undetectable		 5x23A-4gl2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A 357
LYS A 349
ASP A 345
SER A 438
LEU A 439
 None
 0.99A 5x6yA-4gl2A:
2.1		 5x6yA-4gl2A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 627
ASN A 631
ASN A 684
TYR A 630
PHE A 629
 None
 1.41A 5xxjA-4gl2A:
2.2		 5xxjA-4gl2A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ARG A 560
MET A 558
THR A 559
LEU A 555
 None
 1.39A 5z86J-4gl2A:
undetectable		 5z86J-4gl2A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A 795
GLU A 444
THR A 488
ARG A 806
GLY A 821
 None
 1.08A 6nknA-4gl2A:
3.3
6nknB-4gl2A:
undetectable
6nknT-4gl2A:
undetectable		 6nknA-4gl2A:
20.84
6nknB-4gl2A:
15.06
6nknT-4gl2A:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 9 ARG A 806
GLY A 821
GLY A 795
GLU A 444
THR A 488
 None
 1.13A 6nknG-4gl2A:
undetectable
6nknN-4gl2A:
1.6
6nknO-4gl2A:
undetectable		 6nknG-4gl2A:
6.42
6nknN-4gl2A:
20.84
6nknO-4gl2A:
15.06