SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 12 ALA A 309
LEU A 310
LEU A 359
LEU A 301
LEU A 294
 None
 1.23A 1errB-4gl8A:
undetectable		 1errB-4gl8A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		4 / 7 LYS A 156
THR A 166
THR A  93
VAL A  91
 None
 0.76A 1ictD-4gl8A:
undetectable		 1ictD-4gl8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 10 LEU A 237
ILE A  57
GLY A  56
PRO A 209
ILE A 240
 None
 0.83A 1sdtA-4gl8A:
undetectable		 1sdtA-4gl8A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 11 LEU A 237
ILE A  57
GLY A  56
PRO A 209
ILE A 240
 None
 0.91A 1sduA-4gl8A:
undetectable		 1sduA-4gl8A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 10 LEU A 237
ILE A  57
GLY A  56
PRO A 209
ILE A 240
 None
 0.86A 1sdvA-4gl8A:
undetectable		 1sdvA-4gl8A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		3 / 3 PHE A 495
TYR A 454
TYR A 459
 None
 0.97A 1x70B-4gl8A:
undetectable		 1x70B-4gl8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 11 ARG A 520
ILE A 165
TYR A 117
ILE A 133
PHE A 174
 None
 1.39A 2fkeA-4gl8A:
undetectable		 2fkeA-4gl8A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 12 PHE A 442
TYR A 459
LEU A 347
TYR A 343
ALA A 482
 None
 1.35A 2iyfB-4gl8A:
undetectable		 2iyfB-4gl8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		3 / 3 PRO A 209
ASN A 522
ARG A  76
 None
 0.97A 2qeuB-4gl8A:
undetectable		 2qeuB-4gl8A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 12 LEU A  44
ARG A 215
ILE A 263
ASN A 266
PHE A  33
 None
 1.32A 2zznB-4gl8A:
undetectable		 2zznB-4gl8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 10 ASP A  45
TYR A 117
SER A 116
GLY A  64
ILE A 184
 None
 1.49A 3a66A-4gl8A:
0.0		 3a66A-4gl8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 12 GLN A 403
ILE A 400
LEU A 404
VAL A 494
LEU A 301
 None
 1.13A 3dzuA-4gl8A:
undetectable		 3dzuA-4gl8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 10 ILE A  49
GLY A  54
GLY A  56
VAL A 179
ILE A 184
 None
 1.08A 3em4V-4gl8A:
undetectable		 3em4V-4gl8A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 12 MET A 177
LEU A 167
PHE A 174
ILE A 133
ALA A 140
 None
 1.07A 3nxuB-4gl8A:
undetectable		 3nxuB-4gl8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		4 / 7 ILE A 526
LYS A 265
PHE A 242
GLY A  56
 None
 0.96A 3sj0X-4gl8A:
undetectable		 3sj0X-4gl8A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 10 ASP A  45
TYR A 117
SER A 116
GLY A  64
ILE A 184
 None
 1.49A 3vwpA-4gl8A:
undetectable		 3vwpA-4gl8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 12 ASP A  45
TYR A 117
SER A 116
GLY A  64
ILE A 184
 None
 1.48A 3vwqA-4gl8A:
undetectable		 3vwqA-4gl8A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		4 / 8 ASN A 497
LEU A 324
TYR A 292
ARG A 425
 None
 1.00A 4ijiF-4gl8A:
undetectable		 4ijiF-4gl8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		3 / 3 GLN A 181
SER A 429
ASP A 431
 None
 0.91A 4qwpA-4gl8A:
undetectable
4qwpB-4gl8A:
undetectable		 4qwpA-4gl8A:
18.32
4qwpB-4gl8A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		5 / 12 ILE A 240
PRO A 209
SER A 103
GLU A 224
PHE A 210
 None
 1.24A 5il1A-4gl8A:
undetectable		 5il1A-4gl8A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		4 / 8 LEU A 118
ILE A 137
LEU A 158
ALA A 157
 None
 0.86A 5y7pC-4gl8A:
undetectable		 5y7pC-4gl8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV
(Borreliella
burgdorferi) 		4 / 8 GLY A  56
THR A  52
SER A  59
TYR A 503
 None
 1.17A 6eqpA-4gl8A:
undetectable		 6eqpA-4gl8A:
8.21