SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4glf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4glf RSFP
(uncultured
bacterium) 		5 / 10 ARG A  34
LEU A  51
GLU A  53
LEU A  30
GLY A  23
 None
 1.39A 1cmcA-4glfA:
undetectable
1cmcB-4glfA:
undetectable		 1cmcA-4glfA:
16.49
1cmcB-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 4glf RSFP
(uncultured
bacterium) 		4 / 4 ARG A 153
ALA A 154
ALA A 258
GLU A 263
 None
 1.11A 1e7bA-4glfA:
undetectable		 1e7bA-4glfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 4glf RSFP
(uncultured
bacterium) 		4 / 4 ARG A 153
ALA A 154
ALA A 258
GLU A 263
 None
 1.05A 1e7bB-4glfA:
undetectable		 1e7bB-4glfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4glf RSFP
(uncultured
bacterium) 		4 / 5 ARG A 153
ALA A 154
ALA A 258
GLU A 263
 None
 1.08A 1e7cA-4glfA:
undetectable		 1e7cA-4glfA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4glf RSFP
(uncultured
bacterium) 		5 / 12 GLY A  23
ARG A  34
LEU A  51
GLU A  53
LEU A  30
 None
 1.28A 1mj2A-4glfA:
undetectable
1mj2B-4glfA:
undetectable		 1mj2A-4glfA:
16.49
1mj2B-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4glf RSFP
(uncultured
bacterium) 		5 / 9 ARG A  34
LEU A  51
GLU A  53
LEU A  30
GLY A  23
 None
 1.37A 1mjlA-4glfA:
undetectable
1mjlB-4glfA:
undetectable		 1mjlA-4glfA:
16.49
1mjlB-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4glf RSFP
(uncultured
bacterium) 		5 / 11 ARG A  34
LEU A  51
GLU A  53
LEU A  30
GLY A  23
 None
 1.27A 1mjqA-4glfA:
undetectable
1mjqB-4glfA:
undetectable		 1mjqA-4glfA:
16.49
1mjqB-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4glf RSFP
(uncultured
bacterium) 		5 / 11 GLY A  23
ARG A  34
LEU A  51
GLU A  53
LEU A  30
 None
 1.28A 1mjqA-4glfA:
undetectable
1mjqB-4glfA:
undetectable		 1mjqA-4glfA:
16.49
1mjqB-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 4glf RSFP
(uncultured
bacterium) 		5 / 10 GLY A  23
ARG A  34
LEU A  51
GLU A  53
LEU A  30
 None
 1.28A 1mjqG-4glfA:
undetectable
1mjqH-4glfA:
undetectable		 1mjqG-4glfA:
16.49
1mjqH-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4glf RSFP
(uncultured
bacterium) 		5 / 11 ARG A  34
LEU A  51
GLU A  53
LEU A  30
GLY A  23
 None
 1.24A 1mjqI-4glfA:
undetectable
1mjqJ-4glfA:
undetectable		 1mjqI-4glfA:
16.49
1mjqJ-4glfA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4glf RSFP
(uncultured
bacterium) 		4 / 5 LEU A 151
VAL A 147
CYH A 144
ALA A 269
 None
 0.94A 1mz9D-4glfA:
undetectable		 1mz9D-4glfA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4glf RSFP
(uncultured
bacterium) 		4 / 4 LEU A 151
VAL A 147
CYH A 144
ALA A 269
 None
 1.00A 1mz9E-4glfA:
undetectable		 1mz9E-4glfA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4glf RSFP
(uncultured
bacterium) 		5 / 10 GLY A 100
PHE A 179
GLY A 197
MET A 198
THR A 221
 None
 0.39A 1pwyE-4glfA:
23.0		 1pwyE-4glfA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4glf RSFP
(uncultured
bacterium) 		5 / 12 GLY A  52
ASN A  81
SER A  46
GLY A  20
ILE A  19
 None
 1.20A 1q8jB-4glfA:
undetectable		 1q8jB-4glfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4glf RSFP
(uncultured
bacterium) 		5 / 10 GLY A 100
PHE A 179
GLY A 197
MET A 198
THR A 221
 None
 0.29A 1v3qE-4glfA:
23.2		 1v3qE-4glfA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4glf RSFP
(uncultured
bacterium) 		5 / 12 PRO A  77
ILE A  19
LEU A  85
ILE A  49
ALA A  60
 None
 1.16A 3a50A-4glfA:
undetectable		 3a50A-4glfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4glf RSFP
(uncultured
bacterium) 		5 / 11 ILE A  82
LEU A  62
ALA A  60
ILE A  49
VAL A  90
 None
 1.16A 3b2rB-4glfA:
undetectable		 3b2rB-4glfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4glf RSFP
(uncultured
bacterium) 		5 / 10 ILE A 212
SER A  95
ASN A 200
ILE A  82
ALA A 210
 None
 1.42A 3u6tA-4glfA:
undetectable		 3u6tA-4glfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4glf RSFP
(uncultured
bacterium) 		5 / 12 ASP A 110
VAL A 220
ASN A 245
GLY A 163
ASP A 162
 None
 1.37A 4pevB-4glfA:
3.6		 4pevB-4glfA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 4glf RSFP
(uncultured
bacterium) 		3 / 3 ARG A  64
TYR A 214
GLU A 203
 None
 0.45A 4zzbE-4glfA:
undetectable		 4zzbE-4glfA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4glf RSFP
(uncultured
bacterium) 		4 / 6 GLY A  20
ILE A 174
TYR A 171
TYR A 214
 None
 1.07A 5iwuA-4glfA:
undetectable		 5iwuA-4glfA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4glf RSFP
(uncultured
bacterium) 		3 / 3 THR A 127
GLU A 209
HIS A 136
 None
 0.91A 5xiqB-4glfA:
2.0		 5xiqB-4glfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4glf RSFP
(uncultured
bacterium) 		3 / 3 THR A 127
GLU A 209
HIS A 136
 None
 0.93A 5xiqD-4glfA:
undetectable		 5xiqD-4glfA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4glf RSFP
(uncultured
bacterium) 		5 / 12 ILE A  16
GLY A  89
ALA A  14
ASN A  12
ALA A  84
 None
 1.01A 5zw4A-4glfA:
undetectable		 5zw4A-4glfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 4glf RSFP
(uncultured
bacterium) 		5 / 11 SER A  97
ARG A  64
ALA A 218
THR A 216
ALA A 207
 None
 1.41A 6efnA-4glfA:
undetectable		 6efnA-4glfA:
20.96