SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4glr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZR_A_H4BA760_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.22A	1zzrA-4glrI: undetectable 1zzrB-4glrI: undetectable	1zzrA-4glrI: 20.86 1zzrB-4glrI: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZR_B_H4BB761_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	GLU I 83 VAL I 106 ARG I 61 VAL I 19	None	1.22A	1zzrA-4glrI: undetectable 1zzrB-4glrI: undetectable	1zzrA-4glrI: 20.86 1zzrB-4glrI: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZU_A_H4BA760_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.21A	1zzuA-4glrI: undetectable 1zzuB-4glrI: undetectable	1zzuA-4glrI: 20.86 1zzuB-4glrI: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZU_B_H4BB761_1 (NITRIC-OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	GLU I 83 VAL I 106 ARG I 61 VAL I 19	None	1.21A	1zzuA-4glrI: undetectable 1zzuB-4glrI: undetectable	1zzuA-4glrI: 20.86 1zzuB-4glrI: 20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2OLD_B_IPHB2001_0 (BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN)	4glr	ANTI-PTAU HEAVY CHAIN ANTI-PTAU LIGHT CHAIN (Gallus gallus; Gallus gallus)	4 / 7	TYR H 91 TYR I 36 PRO I 44 TYR I 87	None	0.63A	2oldA-4glrH: 18.5 2oldB-4glrH: 16.3	2oldA-4glrH: 31.40 2oldB-4glrH: 31.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2OLD_B_IPHB2001_0 (BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN)	4glr	ANTI-PTAU HEAVY CHAIN ANTI-PTAU LIGHT CHAIN (Gallus gallus; Gallus gallus)	4 / 7	TYR I 36 PRO I 44 TYR I 87 TYR H 91	None	0.56A	2oldA-4glrI: 19.9 2oldB-4glrI: 23.3	2oldA-4glrI: 75.58 2oldB-4glrI: 75.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCT_D_ASDD1223_1 (GLUTATHIONE S-TRANSFERASE A2)	4glr	ANTI-PTAU HEAVY CHAIN ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	ILE H 100 GLY H 100 LEU I 4 PHE I 98	None	1.02A	2vctD-4glrH: undetectable	2vctD-4glrH: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DQR_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.25A	3dqrA-4glrI: undetectable 3dqrB-4glrI: undetectable	3dqrA-4glrI: 19.08 3dqrB-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX2_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.15A	3jx2A-4glrI: undetectable 3jx2B-4glrI: undetectable	3jx2A-4glrI: 19.08 3jx2B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX3_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.20A	3jx3A-4glrI: undetectable 3jx3B-4glrI: undetectable	3jx3A-4glrI: 19.08 3jx3B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX3_B_H4BB760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	GLU I 83 VAL I 106 ARG I 61 VAL I 19	None	1.16A	3jx3A-4glrI: undetectable 3jx3B-4glrI: undetectable	3jx3A-4glrI: 19.08 3jx3B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX5_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.18A	3jx5A-4glrI: undetectable 3jx5B-4glrI: undetectable	3jx5A-4glrI: 19.08 3jx5B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX6_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.13A	3jx6A-4glrI: undetectable 3jx6B-4glrI: undetectable	3jx6A-4glrI: 19.08 3jx6B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JX6_B_H4BB761_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	GLU I 83 VAL I 106 ARG I 61 VAL I 19	None	1.18A	3jx6A-4glrI: undetectable 3jx6B-4glrI: undetectable	3jx6A-4glrI: 19.08 3jx6B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LXI_A_CAMA423_0 (CYTOCHROME P450)	4glr	ANTI-PTAU HEAVY CHAIN ANTI-PTAU LIGHT CHAIN (Gallus gallus; Gallus gallus)	5 / 10	TYR H 91 THR H 89 LEU H 45 GLY H 44 VAL I 85	None	1.29A	3lxiA-4glrH: undetectable	3lxiA-4glrH: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NBR_A_ASDA129_1 (STEROID DELTA-ISOMERASE)	4glr	ANTI-PTAU HEAVY CHAIN ANTI-PTAU LIGHT CHAIN (Gallus gallus)	5 / 12	PHE H 166 VAL I 195 VAL I 144 PRO I 113 PHE I 139	None	1.36A	3nbrA-4glrH: undetectable	3nbrA-4glrH: 18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NLJ_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.15A	3nljA-4glrI: undetectable 3nljB-4glrI: undetectable	3nljA-4glrI: 19.08 3nljB-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NLP_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.16A	3nlpA-4glrI: undetectable 3nlpB-4glrI: undetectable	3nlpA-4glrI: 19.08 3nlpB-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NLQ_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 8	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.16A	3nlqA-4glrI: undetectable 3nlqB-4glrI: undetectable	3nlqA-4glrI: 19.08 3nlqB-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NLR_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.16A	3nlrA-4glrI: undetectable 3nlrB-4glrI: undetectable	3nlrA-4glrI: 19.08 3nlrB-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_B_SAMB300_1 (SAM-DEPENDENT METHYLTRANSFERASE)	4glr	ANTI-PTAU HEAVY CHAIN ANTI-PTAU LIGHT CHAIN (Gallus gallus; Gallus gallus)	3 / 3	TYR H 32 ASP H 101 ASP I 57	None	0.79A	3ou6B-4glrH: undetectable	3ou6B-4glrH: 22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_A_MTXA2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	VAL H 2 MET H 34 ARG H 71 ASN H 73 VAL H 78	None	0.52A	3qxvA-4glrH: 21.0	3qxvA-4glrH: 30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3QXV_C_MTXC2000_1 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	VAL H 2 MET H 34 ARG H 71 ASN H 73 VAL H 78	None	0.60A	3qxvC-4glrH: 21.1	3qxvC-4glrH: 30.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4C9P_A_CAMA423_0 (CYTOCHROME P450)	4glr	ANTI-PTAU HEAVY CHAIN ANTI-PTAU LIGHT CHAIN (Gallus gallus; Gallus gallus)	5 / 9	TYR H 91 THR H 89 LEU H 45 GLY H 44 VAL I 85	None	1.34A	4c9pA-4glrH: undetectable	4c9pA-4glrH: 20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX3_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.22A	4cx3A-4glrI: undetectable 4cx3B-4glrI: undetectable	4cx3A-4glrI: 19.08 4cx3B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX3_B_H4BB760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	GLU I 83 VAL I 106 ARG I 61 VAL I 19	None	1.19A	4cx3A-4glrI: undetectable 4cx3B-4glrI: undetectable	4cx3A-4glrI: 19.08 4cx3B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX4_A_H4BA760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	VAL I 106 ARG I 61 VAL I 19 GLU I 83	None	1.23A	4cx4A-4glrI: undetectable 4cx4B-4glrI: undetectable	4cx4A-4glrI: 19.08 4cx4B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CX4_B_H4BB760_1 (NITRIC OXIDE SYNTHASE, BRAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 7	GLU I 83 VAL I 106 ARG I 61 VAL I 19	None	1.19A	4cx4A-4glrI: undetectable 4cx4B-4glrI: undetectable	4cx4A-4glrI: 19.08 4cx4B-4glrI: 19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA502_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	4 / 8	LEU H 18 ARG H 38 VAL H 109 VAL H 111	None	1.00A	4em2A-4glrH: undetectable	4em2A-4glrH: 18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.75A	4qvpH-4glrH: undetectable 4qvpI-4glrH: undetectable	4qvpH-4glrH: 23.72 4qvpI-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.75A	4qvpV-4glrH: undetectable 4qvpW-4glrH: undetectable	4qvpV-4glrH: 23.72 4qvpW-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.80A	4qvvH-4glrH: undetectable	4qvvH-4glrH: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.79A	4qvvV-4glrH: undetectable	4qvvV-4glrH: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVY_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.79A	4qvyH-4glrH: undetectable	4qvyH-4glrH: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVY_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.79A	4qvyV-4glrH: undetectable 4qvyW-4glrH: undetectable	4qvyV-4glrH: 23.72 4qvyW-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.78A	4qw0H-4glrH: undetectable 4qw0I-4glrH: undetectable	4qw0H-4glrH: 23.72 4qw0I-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QW0_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.78A	4qw0V-4glrH: undetectable 4qw0W-4glrH: undetectable	4qw0V-4glrH: 23.72 4qw0W-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE2_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	GLY H 60 LEU H 82 GLY H 10 THR H 107 LEU H 20	None	1.04A	4ze2A-4glrH: undetectable	4ze2A-4glrH: 18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ALB_L_TIQL1210_2 (MEDI2452 LIGHT CHAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 8	TYR I 36 GLY I 89 GLY I 96 PHE I 98	None	0.28A	5albL-4glrI: 21.0	5albL-4glrI: 77.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5ALC_L_TIQL1210_2 (ANTI-TICAGRELOR FAB 72, LIGHT CHAIN)	4glr	ANTI-PTAU LIGHT CHAIN (Gallus gallus)	4 / 8	TYR I 36 GLY I 89 GLY I 96 PHE I 98	None	0.31A	5alcL-4glrI: 24.5	5alcL-4glrI: 78.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BXN_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.77A	5bxnH-4glrH: undetectable 5bxnI-4glrH: undetectable	5bxnH-4glrH: 23.72 5bxnI-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CZ7_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.78A	5cz7V-4glrH: undetectable 5cz7W-4glrH: undetectable	5cz7V-4glrH: 23.72 5cz7W-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5D0X_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.77A	5d0xV-4glrH: undetectable	5d0xV-4glrH: 23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.74A	5l5fH-4glrH: undetectable 5l5fI-4glrH: undetectable	5l5fH-4glrH: 23.72 5l5fI-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.74A	5l5fV-4glrH: undetectable 5l5fW-4glrH: undetectable	5l5fV-4glrH: 23.72 5l5fW-4glrH: 24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_H_BO2H301_0 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 12	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.85A	6hwdH-4glrH: undetectable 6hwdI-4glrH: undetectable	6hwdH-4glrH: 18.41 6hwdI-4glrH: 17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_V_BO2V301_0 (PROTEASOME SUBUNIT BETA TYPE-2)	4glr	ANTI-PTAU HEAVY CHAIN (Gallus gallus)	5 / 11	SER H 188 GLY H 134 THR H 135 ALA H 136 THR H 131	None	0.85A	6hwdV-4glrH: undetectable	6hwdV-4glrH: 18.41

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ZZR_A_H4BA760_1","NITRIC-OXIDE SYNTHASE, BRAIN;NITRIC-OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.22A","1zzrA-4glrI:undetectable;1zzrB-4glrI:undetectable","1zzrA-4glrI:20.86;1zzrB-4glrI:20.86"],["1ZZR_B_H4BB761_1","NITRIC-OXIDE SYNTHASE, BRAIN;NITRIC-OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"GLU I  83;VAL I 106;ARG I  61;VAL I  19","None","1.22A","1zzrA-4glrI:undetectable;1zzrB-4glrI:undetectable","1zzrA-4glrI:20.86;1zzrB-4glrI:20.86"],["1ZZU_A_H4BA760_1","NITRIC-OXIDE SYNTHASE, BRAIN;NITRIC-OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.21A","1zzuA-4glrI:undetectable;1zzuB-4glrI:undetectable","1zzuA-4glrI:20.86;1zzuB-4glrI:20.86"],["1ZZU_B_H4BB761_1","NITRIC-OXIDE SYNTHASE, BRAIN;NITRIC-OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"GLU I  83;VAL I 106;ARG I  61;VAL I  19","None","1.21A","1zzuA-4glrI:undetectable;1zzuB-4glrI:undetectable","1zzuA-4glrI:20.86;1zzuB-4glrI:20.86"],["2OLD_B_IPHB2001_0","BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN","4glr","ANTI-PTAU HEAVY CHAIN;ANTI-PTAU LIGHT CHAIN","Gallus gallus;Gallus gallus",4,"TYR H  91;TYR I  36;PRO I  44;TYR I  87","None","0.63A","2oldA-4glrH:18.5;2oldB-4glrH:16.3","2oldA-4glrH:31.40;2oldB-4glrH:31.40"],["2OLD_B_IPHB2001_0","BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN","4glr","ANTI-PTAU HEAVY CHAIN;ANTI-PTAU LIGHT CHAIN","Gallus gallus;Gallus gallus",4,"TYR I  36;PRO I  44;TYR I  87;TYR H  91","None","0.56A","2oldA-4glrI:19.9;2oldB-4glrI:23.3","2oldA-4glrI:75.58;2oldB-4glrI:75.58"],["2VCT_D_ASDD1223_1","GLUTATHIONE S-TRANSFERASE A2","4glr","ANTI-PTAU HEAVY CHAIN;ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"ILE H 100;GLY H 100;LEU I   4;PHE I  98","None","1.02A","2vctD-4glrH:undetectable","2vctD-4glrH:21.51"],["3DQR_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.25A","3dqrA-4glrI:undetectable;3dqrB-4glrI:undetectable","3dqrA-4glrI:19.08;3dqrB-4glrI:19.08"],["3JX2_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.15A","3jx2A-4glrI:undetectable;3jx2B-4glrI:undetectable","3jx2A-4glrI:19.08;3jx2B-4glrI:19.08"],["3JX3_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.20A","3jx3A-4glrI:undetectable;3jx3B-4glrI:undetectable","3jx3A-4glrI:19.08;3jx3B-4glrI:19.08"],["3JX3_B_H4BB760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"GLU I  83;VAL I 106;ARG I  61;VAL I  19","None","1.16A","3jx3A-4glrI:undetectable;3jx3B-4glrI:undetectable","3jx3A-4glrI:19.08;3jx3B-4glrI:19.08"],["3JX5_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.18A","3jx5A-4glrI:undetectable;3jx5B-4glrI:undetectable","3jx5A-4glrI:19.08;3jx5B-4glrI:19.08"],["3JX6_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.13A","3jx6A-4glrI:undetectable;3jx6B-4glrI:undetectable","3jx6A-4glrI:19.08;3jx6B-4glrI:19.08"],["3JX6_B_H4BB761_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"GLU I  83;VAL I 106;ARG I  61;VAL I  19","None","1.18A","3jx6A-4glrI:undetectable;3jx6B-4glrI:undetectable","3jx6A-4glrI:19.08;3jx6B-4glrI:19.08"],["3LXI_A_CAMA423_0","CYTOCHROME P450","4glr","ANTI-PTAU HEAVY CHAIN;ANTI-PTAU LIGHT CHAIN","Gallus gallus;Gallus gallus",5,"TYR H  91;THR H  89;LEU H  45;GLY H  44;VAL I  85","None","1.29A","3lxiA-4glrH:undetectable","3lxiA-4glrH:20.76"],["3NBR_A_ASDA129_1","STEROID DELTA-ISOMERASE","4glr","ANTI-PTAU HEAVY CHAIN;ANTI-PTAU LIGHT CHAIN","Gallus gallus",5,"PHE H 166;VAL I 195;VAL I 144;PRO I 113;PHE I 139","None","1.36A","3nbrA-4glrH:undetectable","3nbrA-4glrH:18.41"],["3NLJ_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.15A","3nljA-4glrI:undetectable;3nljB-4glrI:undetectable","3nljA-4glrI:19.08;3nljB-4glrI:19.08"],["3NLP_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.16A","3nlpA-4glrI:undetectable;3nlpB-4glrI:undetectable","3nlpA-4glrI:19.08;3nlpB-4glrI:19.08"],["3NLQ_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.16A","3nlqA-4glrI:undetectable;3nlqB-4glrI:undetectable","3nlqA-4glrI:19.08;3nlqB-4glrI:19.08"],["3NLR_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.16A","3nlrA-4glrI:undetectable;3nlrB-4glrI:undetectable","3nlrA-4glrI:19.08;3nlrB-4glrI:19.08"],["3OU6_B_SAMB300_1","SAM-DEPENDENT METHYLTRANSFERASE","4glr","ANTI-PTAU HEAVY CHAIN;ANTI-PTAU LIGHT CHAIN","Gallus gallus;Gallus gallus",3,"TYR H  32;ASP H 101;ASP I  57","None","0.79A","3ou6B-4glrH:undetectable","3ou6B-4glrH:22.83"],["3QXV_A_MTXA2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"VAL H   2;MET H  34;ARG H  71;ASN H  73;VAL H  78","None","0.52A","3qxvA-4glrH:21.0","3qxvA-4glrH:30.30"],["3QXV_C_MTXC2000_1","ANTI-METHOTREXATE CDR1-4 GRAFT VHH","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"VAL H   2;MET H  34;ARG H  71;ASN H  73;VAL H  78","None","0.60A","3qxvC-4glrH:21.1","3qxvC-4glrH:30.30"],["4C9P_A_CAMA423_0","CYTOCHROME P450","4glr","ANTI-PTAU HEAVY CHAIN;ANTI-PTAU LIGHT CHAIN","Gallus gallus;Gallus gallus",5,"TYR H  91;THR H  89;LEU H  45;GLY H  44;VAL I  85","None","1.34A","4c9pA-4glrH:undetectable","4c9pA-4glrH:20.76"],["4CX3_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.22A","4cx3A-4glrI:undetectable;4cx3B-4glrI:undetectable","4cx3A-4glrI:19.08;4cx3B-4glrI:19.08"],["4CX3_B_H4BB760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"GLU I  83;VAL I 106;ARG I  61;VAL I  19","None","1.19A","4cx3A-4glrI:undetectable;4cx3B-4glrI:undetectable","4cx3A-4glrI:19.08;4cx3B-4glrI:19.08"],["4CX4_A_H4BA760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"VAL I 106;ARG I  61;VAL I  19;GLU I  83","None","1.23A","4cx4A-4glrI:undetectable;4cx4B-4glrI:undetectable","4cx4A-4glrI:19.08;4cx4B-4glrI:19.08"],["4CX4_B_H4BB760_1","NITRIC OXIDE SYNTHASE, BRAIN;NITRIC OXIDE SYNTHASE, BRAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"GLU I  83;VAL I 106;ARG I  61;VAL I  19","None","1.19A","4cx4A-4glrI:undetectable;4cx4B-4glrI:undetectable","4cx4A-4glrI:19.08;4cx4B-4glrI:19.08"],["4EM2_A_SALA502_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",4,"LEU H  18;ARG H  38;VAL H 109;VAL H 111","None","1.00A","4em2A-4glrH:undetectable","4em2A-4glrH:18.64"],["4QVP_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.75A","4qvpH-4glrH:undetectable;4qvpI-4glrH:undetectable","4qvpH-4glrH:23.72;4qvpI-4glrH:24.18"],["4QVP_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.75A","4qvpV-4glrH:undetectable;4qvpW-4glrH:undetectable","4qvpV-4glrH:23.72;4qvpW-4glrH:24.18"],["4QVV_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.80A","4qvvH-4glrH:undetectable","4qvvH-4glrH:23.72"],["4QVV_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.79A","4qvvV-4glrH:undetectable","4qvvV-4glrH:23.72"],["4QVY_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.79A","4qvyH-4glrH:undetectable","4qvyH-4glrH:23.72"],["4QVY_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.79A","4qvyV-4glrH:undetectable;4qvyW-4glrH:undetectable","4qvyV-4glrH:23.72;4qvyW-4glrH:24.18"],["4QW0_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.78A","4qw0H-4glrH:undetectable;4qw0I-4glrH:undetectable","4qw0H-4glrH:23.72;4qw0I-4glrH:24.18"],["4QW0_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.78A","4qw0V-4glrH:undetectable;4qw0W-4glrH:undetectable","4qw0V-4glrH:23.72;4qw0W-4glrH:24.18"],["4ZE2_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"GLY H  60;LEU H  82;GLY H  10;THR H 107;LEU H  20","None","1.04A","4ze2A-4glrH:undetectable","4ze2A-4glrH:18.88"],["5ALB_L_TIQL1210_2","MEDI2452 LIGHT CHAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"TYR I  36;GLY I  89;GLY I  96;PHE I  98","None","0.28A","5albL-4glrI:21.0","5albL-4glrI:77.88"],["5ALC_L_TIQL1210_2","ANTI-TICAGRELOR FAB 72, LIGHT CHAIN","4glr","ANTI-PTAU LIGHT CHAIN","Gallus gallus",4,"TYR I  36;GLY I  89;GLY I  96;PHE I  98","None","0.31A","5alcL-4glrI:24.5","5alcL-4glrI:78.80"],["5BXN_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.77A","5bxnH-4glrH:undetectable;5bxnI-4glrH:undetectable","5bxnH-4glrH:23.72;5bxnI-4glrH:24.18"],["5CZ7_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.78A","5cz7V-4glrH:undetectable;5cz7W-4glrH:undetectable","5cz7V-4glrH:23.72;5cz7W-4glrH:24.18"],["5D0X_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.77A","5d0xV-4glrH:undetectable","5d0xV-4glrH:23.72"],["5L5F_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.74A","5l5fH-4glrH:undetectable;5l5fI-4glrH:undetectable","5l5fH-4glrH:23.72;5l5fI-4glrH:24.18"],["5L5F_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.74A","5l5fV-4glrH:undetectable;5l5fW-4glrH:undetectable","5l5fV-4glrH:23.72;5l5fW-4glrH:24.18"],["6HWD_H_BO2H301_0","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.85A","6hwdH-4glrH:undetectable;6hwdI-4glrH:undetectable","6hwdH-4glrH:18.41;6hwdI-4glrH:17.62"],["6HWD_V_BO2V301_0","PROTEASOME SUBUNIT BETA TYPE-2","4glr","ANTI-PTAU HEAVY CHAIN","Gallus gallus",5,"SER H 188;GLY H 134;THR H 135;ALA H 136;THR H 131","None","0.85A","6hwdV-4glrH:undetectable","6hwdV-4glrH:18.41"]]