SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4glt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		5 / 12 MET A 137
LEU A 134
MET A 162
GLY A  99
LEU A  96
 None
 1.25A 1g50B-4gltA:
undetectable		 1g50B-4gltA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		5 / 12 LEU A  33
VAL A  31
SER A   9
VAL A  15
LEU A   3
 GSH  A 301 (-4.9A)
None
GSH  A 301 (-2.7A)
None
None
 0.85A 1mx1E-4gltA:
undetectable		 1mx1E-4gltA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		5 / 10 GLY A 160
VAL A 159
LEU A 182
LEU A 134
ALA A  97
 None
 1.29A 1pbcA-4gltA:
undetectable		 1pbcA-4gltA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		5 / 11 ALA A  97
CYH A 161
GLY A 160
ILE A 157
VAL A  67
 None
 1.32A 2uxpB-4gltA:
undetectable		 2uxpB-4gltA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.33A 3dqrA-4gltA:
undetectable
3dqrB-4gltA:
undetectable		 3dqrA-4gltA:
19.07
3dqrB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.29A 3jx2A-4gltA:
undetectable
3jx2B-4gltA:
undetectable		 3jx2A-4gltA:
19.07
3jx2B-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.26A 3jx3A-4gltA:
undetectable
3jx3B-4gltA:
undetectable		 3jx3A-4gltA:
19.07
3jx3B-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 6 VAL A  76
ARG A 192
VAL A  18
PHE A 152
 None
 1.31A 3jx4A-4gltA:
undetectable
3jx4B-4gltA:
1.2		 3jx4A-4gltA:
19.07
3jx4B-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.28A 3jx4A-4gltA:
undetectable
3jx4B-4gltA:
undetectable		 3jx4A-4gltA:
19.07
3jx4B-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.29A 3jx5A-4gltA:
undetectable
3jx5B-4gltA:
undetectable		 3jx5A-4gltA:
19.07
3jx5B-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.26A 3jx6A-4gltA:
undetectable
3jx6B-4gltA:
1.2		 3jx6A-4gltA:
19.07
3jx6B-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.25A 3nljA-4gltA:
1.1
3nljB-4gltA:
undetectable		 3nljA-4gltA:
19.07
3nljB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 VAL A  76
ARG A 192
VAL A  18
PHE A 152
 None
 1.28A 3nlpA-4gltA:
undetectable
3nlpB-4gltA:
undetectable		 3nlpA-4gltA:
19.07
3nlpB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.26A 3nlpA-4gltA:
undetectable
3nlpB-4gltA:
undetectable		 3nlpA-4gltA:
19.07
3nlpB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.27A 3nlqA-4gltA:
undetectable
3nlqB-4gltA:
undetectable		 3nlqA-4gltA:
19.07
3nlqB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 VAL A  76
ARG A 192
VAL A  18
PHE A 152
 None
 1.28A 3nlrA-4gltA:
undetectable
3nlrB-4gltA:
undetectable		 3nlrA-4gltA:
19.07
3nlrB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		6 / 12 GLY A 160
PRO A  10
ALA A 104
LEU A 182
LEU A 166
TYR A 170
 None
GSH  A 301 (-4.4A)
None
None
None
None
 1.30A 3p2kD-4gltA:
undetectable		 3p2kD-4gltA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.30A 4cx4A-4gltA:
1.1
4cx4B-4gltA:
undetectable		 4cx4A-4gltA:
19.07
4cx4B-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 4 ALA A 155
VAL A 159
ASP A 156
LEU A 141
 None
 0.75A 4e7gA-4gltA:
undetectable		 4e7gA-4gltA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 SER A   9
VAL A 105
TYR A 165
ARG A 169
 GSH  A 301 (-2.7A)
GSH  A 301 ( 4.8A)
GSH  A 301 (-4.7A)
GSH  A 301 (-4.1A)
 0.67A 4ijiH-4gltA:
25.9		 4ijiH-4gltA:
35.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 6 VAL A  76
ARG A 192
VAL A  18
PHE A 152
 None
 1.30A 5addA-4gltA:
undetectable
5addB-4gltA:
undetectable		 5addA-4gltA:
19.07
5addB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.28A 5addA-4gltA:
undetectable
5addB-4gltA:
undetectable		 5addA-4gltA:
19.07
5addB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 6 VAL A  76
ARG A 192
VAL A  18
PHE A 152
 None
 1.27A 5adeA-4gltA:
undetectable
5adeB-4gltA:
undetectable		 5adeA-4gltA:
19.07
5adeB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.26A 5adeA-4gltA:
undetectable
5adeB-4gltA:
undetectable		 5adeA-4gltA:
19.07
5adeB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 ALA A 158
ASP A 140
ARG A 136
GLY A 133
 None
 0.88A 5bs8A-4gltA:
undetectable
5bs8C-4gltA:
undetectable
5bs8D-4gltA:
undetectable		 5bs8A-4gltA:
18.27
5bs8C-4gltA:
18.27
5bs8D-4gltA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 ALA A 158
ASP A 140
ARG A 136
GLY A 133
 None
 0.91A 5btdA-4gltA:
undetectable
5btdB-4gltA:
undetectable
5btdC-4gltA:
undetectable		 5btdA-4gltA:
18.27
5btdB-4gltA:
21.37
5btdC-4gltA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 ALA A 158
ASP A 140
ARG A 136
GLY A 133
 None
 0.86A 5btdA-4gltA:
undetectable
5btdC-4gltA:
undetectable
5btdD-4gltA:
undetectable		 5btdA-4gltA:
18.27
5btdC-4gltA:
18.27
5btdD-4gltA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		4 / 7 PHE A 152
VAL A  76
ARG A 192
VAL A  18
 None
 1.28A 5g0pA-4gltA:
undetectable
5g0pB-4gltA:
undetectable		 5g0pA-4gltA:
19.07
5g0pB-4gltA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		3 / 3 GLU A  68
TYR A  69
ARG A  73
 None
 0.74A 5uunA-4gltA:
19.1		 5uunA-4gltA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4glt GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN
(Methylobacillus
flagellatus) 		3 / 3 GLU A  68
TYR A  69
ARG A  73
 None
 0.69A 5uunB-4gltA:
19.2		 5uunB-4gltA:
23.38