SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4glw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		4 / 7 ALA A 126
SER A 114
SER A 116
THR A 118
 None
 0.38A 1dvxA-4glwA:
undetectable		 1dvxA-4glwA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		3 / 3 LEU A 234
TYR A 233
GLN A 236
 None
 0.65A 2wekA-4glwA:
undetectable		 2wekA-4glwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 104
VAL A  95
THR A 103
 None
 0.88A 2ygnA-4glwA:
undetectable		 2ygnA-4glwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		4 / 5 VAL A 275
VAL A 276
GLN A  80
ARG A  94
 None
0XT  A 402 (-4.6A)
None
None
 1.35A 3bjwB-4glwA:
undetectable		 3bjwB-4glwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		4 / 6 ARG A 199
THR A 129
ALA A 194
ALA A 195
 None
 1.18A 3ns1C-4glwA:
undetectable		 3ns1C-4glwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		5 / 12 GLU A 107
LYS A 109
GLU A 164
VAL A 276
LYS A 278
 0XT  A 402 (-3.7A)
0XT  A 402 ( 4.4A)
0XT  A 402 ( 4.5A)
0XT  A 402 (-4.6A)
0XT  A 402 (-2.8A)
 0.52A 3qwuA-4glwA:
10.5		 3qwuA-4glwA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		5 / 11 GLU A 107
LYS A 109
GLU A 164
VAL A 276
LYS A 278
 0XT  A 402 (-3.7A)
0XT  A 402 ( 4.4A)
0XT  A 402 ( 4.5A)
0XT  A 402 (-4.6A)
0XT  A 402 (-2.8A)
 0.52A 3qwuB-4glwA:
11.1		 3qwuB-4glwA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		4 / 4 ASN A 138
SER A 116
ALA A 126
VAL A 125
 None
 1.31A 4x1kC-4glwA:
undetectable		 4x1kC-4glwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 4glw DNA LIGASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 127
VAL A 146
GLY A 163
LEU A 211
ILE A 149
 None
 1.03A 6dh6B-4glwA:
undetectable		 6dh6B-4glwA:
12.30