SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4glx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 11 VAL A 121
VAL A 174
GLU A 169
LEU A 130
ILE A 155
 None
 1.41A 1t6zB-4glxA:
undetectable		 1t6zB-4glxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 LEU A 538
LEU A 535
PHE A 564
ALA A 509
THR A 507
 None
None
None
None
SO4  A 602 ( 3.9A)
 1.13A 2v0mC-4glxA:
undetectable		 2v0mC-4glxA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 9 LEU A 576
LEU A 535
ALA A 514
LEU A 512
PHE A 564
 None
 1.24A 2vcvD-4glxA:
2.5		 2vcvD-4glxA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 10 ALA A 541
LEU A 546
LEU A 528
ILE A 517
PHE A 564
 None
 1.03A 2w9hA-4glxA:
undetectable		 2w9hA-4glxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 GLN A 435
GLY A 521
SER A 439
SER A 445
ALA A 448
 None
 1.25A 3d91A-4glxA:
undetectable		 3d91A-4glxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 LEU A 538
LEU A 546
GLN A 547
VAL A 552
ILE A 517
 None
 1.05A 3datA-4glxA:
undetectable		 3datA-4glxA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4glx DNA LIGASE
(Escherichia
coli) 		3 / 3 THR A 135
LYS A 194
GLU A 143
 None
 1.00A 3ijdB-4glxA:
undetectable		 3ijdB-4glxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 4glx DNA LIGASE
(Escherichia
coli) 		3 / 3 ASP A 138
ARG A 447
ARG A  74
 SO4  A 602 ( 4.9A)
None
SO4  A 602 (-2.5A)
 0.98A 3k37A-4glxA:
undetectable		 3k37A-4glxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 GLU A 113
LYS A 115
ARG A 136
GLU A 173
VAL A 288
 0XS  A 603 (-4.0A)
0XS  A 603 (-4.3A)
None
0XS  A 603 (-3.5A)
0XS  A 603 (-4.6A)
 1.13A 3qwuA-4glxA:
10.1		 3qwuA-4glxA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_A_ADNA501_1
(DNA LIGASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 GLU A 113
LYS A 115
GLU A 173
VAL A 288
LYS A 290
 0XS  A 603 (-4.0A)
0XS  A 603 (-4.3A)
0XS  A 603 (-3.5A)
0XS  A 603 (-4.6A)
0XS  A 603 (-2.9A)
 0.53A 3qwuA-4glxA:
10.1		 3qwuA-4glxA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 11 GLU A 113
LYS A 115
ARG A 136
GLU A 173
VAL A 288
 0XS  A 603 (-4.0A)
0XS  A 603 (-4.3A)
None
0XS  A 603 (-3.5A)
0XS  A 603 (-4.6A)
 0.98A 3qwuB-4glxA:
4.8		 3qwuB-4glxA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWU_B_ADNB501_1
(DNA LIGASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 11 GLU A 113
LYS A 115
GLU A 173
VAL A 288
LYS A 290
 0XS  A 603 (-4.0A)
0XS  A 603 (-4.3A)
0XS  A 603 (-3.5A)
0XS  A 603 (-4.6A)
0XS  A 603 (-2.9A)
 0.42A 3qwuB-4glxA:
4.8		 3qwuB-4glxA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 PHE A 443
ILE A 573
LEU A 576
THR A 507
VAL A 581
 None
None
None
SO4  A 602 ( 3.9A)
None
 0.99A 3rukA-4glxA:
undetectable		 3rukA-4glxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 PHE A 443
ILE A 573
LEU A 576
THR A 507
VAL A 581
 None
None
None
SO4  A 602 ( 3.9A)
None
 1.00A 3rukB-4glxA:
undetectable		 3rukB-4glxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 8 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.82A 3u5kA-4glxA:
undetectable		 3u5kA-4glxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 7 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.72A 3u5kB-4glxA:
undetectable		 3u5kB-4glxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 8 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.77A 3u5kC-4glxA:
undetectable		 3u5kC-4glxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 7 ILE A 573
PHE A 508
HIS A 561
VAL A 552
 None
 0.99A 4a97A-4glxA:
3.1		 4a97A-4glxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 6 ILE A 573
PHE A 508
HIS A 561
VAL A 552
 None
 0.98A 4a97I-4glxA:
2.7		 4a97I-4glxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 5 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.76A 4a9jA-4glxA:
undetectable		 4a9jA-4glxA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 5 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.75A 4a9jB-4glxA:
undetectable		 4a9jB-4glxA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 5 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.83A 4a9jC-4glxA:
undetectable		 4a9jC-4glxA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4glx DNA LIGASE
(Escherichia
coli) 		3 / 3 ARG A  40
ARG A  43
ILE A  73
 None
 0.85A 4b7qA-4glxA:
undetectable		 4b7qA-4glxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 8 ARG A 167
GLU A 126
GLU A 169
ARG A 171
 None
 1.18A 4bqfB-4glxA:
undetectable		 4bqfB-4glxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 8 ARG A 510
GLN A  72
GLY A 142
THR A 140
 SO4  A 602 (-4.1A)
None
None
SO4  A 602 ( 3.9A)
 0.94A 4k87A-4glxA:
undetectable		 4k87A-4glxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 GLU A 328
VAL A 327
PRO A 339
THR A 338
GLY A 335
 None
 1.45A 4ydqB-4glxA:
undetectable		 4ydqB-4glxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 9 PHE A 532
TYR A 531
VAL A 552
GLY A 553
VAL A 560
 None
 1.29A 5cp4A-4glxA:
undetectable		 5cp4A-4glxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4glx DNA LIGASE
(Escherichia
coli) 		5 / 12 ALA A 525
LEU A 528
ALA A 529
PHE A 532
THR A 507
 None
None
None
None
SO4  A 602 ( 3.9A)
 1.15A 5k9dA-4glxA:
undetectable		 5k9dA-4glxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 6 ASN A 495
VAL A 497
LEU A 477
GLN A 494
 None
 1.32A 5xdhA-4glxA:
undetectable
5xdhC-4glxA:
undetectable		 5xdhA-4glxA:
9.84
5xdhC-4glxA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 8 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.76A 5y1yA-4glxA:
undetectable		 5y1yA-4glxA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 8 LEU A 512
VAL A 520
VAL A 549
VAL A 552
 None
 1.04A 6cp4A-4glxA:
undetectable		 6cp4A-4glxA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 6 VAL A 170
LEU A 235
ARG A 242
HIS A 239
 None
 0.97A 6e43A-4glxA:
undetectable		 6e43A-4glxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 6 VAL A 170
LEU A 235
ARG A 242
HIS A 239
 None
 0.97A 6e43B-4glxA:
undetectable		 6e43B-4glxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 6 VAL A 170
LEU A 235
ARG A 242
HIS A 239
 None
 0.99A 6e43C-4glxA:
undetectable		 6e43C-4glxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4glx DNA LIGASE
(Escherichia
coli) 		4 / 6 VAL A 170
LEU A 235
ARG A 242
HIS A 239
 None
 1.00A 6e43D-4glxA:
2.4		 6e43D-4glxA:
21.77