SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gm2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Plasmodium
falciparum) 		3 / 3 LEU A 241
LEU A 165
SER A 168
 None
 0.62A 1tlmA-4gm2A:
undetectable		 1tlmA-4gm2A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Plasmodium
falciparum) 		4 / 7 ILE A 149
LEU A  72
ILE A 116
ASP A 109
 None
 0.95A 1yc2E-4gm2A:
undetectable		 1yc2E-4gm2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Plasmodium
falciparum) 		4 / 6 GLY A 120
SER A  81
ILE A 121
ILE A 178
 None
 0.94A 3a7eA-4gm2A:
undetectable		 3a7eA-4gm2A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Plasmodium
falciparum) 		5 / 12 GLY A 144
LEU A 143
PHE A 170
ALA A 228
SER A 164
 None
 1.11A 3tbgB-4gm2A:
undetectable		 3tbgB-4gm2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Plasmodium
falciparum) 		5 / 12 GLY A 144
LEU A 143
PHE A 170
ALA A 228
SER A 164
 None
 1.10A 3tbgD-4gm2A:
undetectable		 3tbgD-4gm2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Plasmodium
falciparum) 		4 / 8 ILE A 115
ASN A 117
GLY A 120
ILE A 121
 None
 0.74A 3wxoA-4gm2A:
undetectable		 3wxoA-4gm2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4gm2 ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Plasmodium
falciparum) 		5 / 11 SER A 106
GLY A 108
ALA A 150
ILE A  70
ILE A  84
 None
 1.10A 4dt8A-4gm2A:
undetectable		 4dt8A-4gm2A:
23.13