SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gmf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		3 / 3 ALA A 241
VAL A 246
TRP A 137
 None
 1.00A 1gmkC-4gmfA:
undetectable
1gmkD-4gmfA:
undetectable		 1gmkC-4gmfA:
4.39
1gmkD-4gmfA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 12 LEU A 239
VAL A 246
LEU A 170
LEU A 138
THR A 136
 None
 1.07A 2egvA-4gmfA:
3.1		 2egvA-4gmfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 12 LEU A 239
VAL A 246
LEU A 170
LEU A 138
THR A 136
 None
 1.05A 2egvB-4gmfA:
4.1		 2egvB-4gmfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		4 / 5 LEU A 168
GLN A 331
THR A 179
HIS A 322
 None
 1.03A 2zj0B-4gmfA:
2.9		 2zj0B-4gmfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		4 / 5 LEU A 168
GLN A 331
THR A 179
HIS A 322
 None
 1.01A 2zj0C-4gmfA:
5.4		 2zj0C-4gmfA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		4 / 5 LEU A 168
GLN A 331
THR A 179
HIS A 322
 None
 1.02A 3ce6B-4gmfA:
7.7		 3ce6B-4gmfA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 12 VAL A  10
VAL A 298
LEU A 302
VAL A  73
GLY A  18
 None
 1.06A 3rr3A-4gmfA:
undetectable		 3rr3A-4gmfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 12 VAL A  10
VAL A 298
LEU A 302
VAL A  73
GLY A  18
 None
 1.06A 3rr3B-4gmfA:
undetectable		 3rr3B-4gmfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 12 VAL A  10
VAL A 298
LEU A 302
VAL A  73
GLY A  18
 None
 1.07A 3rr3C-4gmfA:
undetectable		 3rr3C-4gmfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 12 VAL A  10
VAL A 298
LEU A 302
VAL A  73
GLY A  18
 None
 1.05A 3rr3D-4gmfA:
undetectable		 3rr3D-4gmfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 11 LEU A 329
THR A 179
VAL A 182
SER A 166
LEU A 207
 None
 1.23A 3tbgA-4gmfA:
undetectable		 3tbgA-4gmfA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 11 ILE A 333
TYR A 165
LEU A 329
THR A 179
VAL A 182
 None
 1.05A 4g1bB-4gmfA:
5.8		 4g1bB-4gmfA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 12 ILE A 333
TYR A 165
LEU A 329
THR A 179
VAL A 182
 None
 1.04A 4g1bD-4gmfA:
2.0		 4g1bD-4gmfA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 10 LEU A 164
LEU A 209
LEU A 196
THR A 167
LEU A 168
 None
 0.89A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 10 LEU A 196
THR A 167
LEU A 168
LEU A 164
LEU A 209
 None
 0.92A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 10 LEU A 198
THR A 167
LEU A 168
LEU A 164
LEU A 209
 None
 0.91A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 10 LEU A 209
LEU A 196
THR A 167
LEU A 168
LEU A 164
 None
 0.92A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 10 THR A 167
LEU A 168
LEU A 164
LEU A 209
LEU A 196
 None
 0.88A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 10 THR A 167
LEU A 168
LEU A 164
LEU A 209
LEU A 196
 None
 0.92A 4z91A-4gmfA:
undetectable
4z91B-4gmfA:
undetectable
4z91C-4gmfA:
undetectable
4z91D-4gmfA:
undetectable
4z91E-4gmfA:
undetectable		 4z91A-4gmfA:
22.00
4z91B-4gmfA:
22.00
4z91C-4gmfA:
22.00
4z91D-4gmfA:
22.00
4z91E-4gmfA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		4 / 8 LEU A 228
LEU A 138
THR A 131
TYR A 128
 None
 0.91A 5hbsA-4gmfA:
1.8		 5hbsA-4gmfA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		4 / 6 HIS A 308
LEU A 309
CYH A 318
HIS A  96
 None
 1.26A 5hrqD-4gmfA:
undetectable
5hrqG-4gmfA:
undetectable
5hrqH-4gmfA:
undetectable		 5hrqD-4gmfA:
5.93
5hrqG-4gmfA:
5.22
5hrqH-4gmfA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 10 ILE A  54
LEU A  34
PHE A  52
GLY A  14
ALA A  39
 None
None
None
SO4  A 401 ( 4.3A)
SO4  A 401 ( 4.0A)
 0.69A 5mxbA-4gmfA:
undetectable		 5mxbA-4gmfA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 12 LEU A 228
THR A 126
ALA A 205
LEU A 326
LEU A 175
 None
 1.29A 6ie8A-4gmfA:
undetectable		 6ie8A-4gmfA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU
(Yersinia
enterocolitica) 		5 / 11 ASN A 125
TYR A 243
ASP A 169
THR A 126
GLY A 134
 None
 1.34A 6mb5A-4gmfA:
undetectable		 6mb5A-4gmfA:
14.25