SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gmj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 8 LEU B  64
TYR B 277
GLY B 261
TYR B  60
 None
GOL  B 303 ( 4.3A)
None
None
 0.99A 1jlfA-4gmjB:
1.3
1jlfB-4gmjB:
1.3		 1jlfA-4gmjB:
19.18
1jlfB-4gmjB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 8 LEU B  64
TYR B 277
GLY B 274
TYR B  60
 None
GOL  B 303 ( 4.3A)
None
None
 0.99A 1jlfA-4gmjB:
1.3
1jlfB-4gmjB:
1.3		 1jlfA-4gmjB:
19.18
1jlfB-4gmjB:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 8 PHE B 189
LEU B 169
LEU B  77
LEU B  79
 None
 0.98A 2bfpA-4gmjB:
undetectable		 2bfpA-4gmjB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 8 PHE B 189
LEU B 169
LEU B  77
LEU B  79
 None
 1.00A 2bfpD-4gmjB:
undetectable		 2bfpD-4gmjB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 12 LEU A1266
LEU A1286
ALA A1261
CYH B 148
LEU B 147
 None
 1.16A 3b0wA-4gmjA:
undetectable		 3b0wA-4gmjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 9 LEU B  65
TYR B 160
VAL B  69
ILE B 168
PHE B  43
 None
None
None
None
GOL  B 303 (-2.9A)
 1.46A 3cs9C-4gmjB:
undetectable		 3cs9C-4gmjB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLY A1300
TYR B 135
LEU A1222
ARG A1308
 None
 0.84A 3elzA-4gmjA:
undetectable		 3elzA-4gmjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE A1262
TYR B 135
LEU A1222
ARG A1308
 None
 0.85A 3elzA-4gmjA:
undetectable		 3elzA-4gmjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		3 / 3 MET A1127
MET A1136
PHE A1152
 None
 1.30A 3gn8A-4gmjA:
undetectable		 3gn8A-4gmjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 5 ILE B 166
PHE B 181
ASP B 180
GLU B 183
 None
 1.12A 3kp6A-4gmjB:
undetectable
3kp6B-4gmjB:
undetectable		 3kp6A-4gmjB:
21.40
3kp6B-4gmjB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		3 / 3 HIS B 249
PHE B 239
PHE B 238
 None
 0.71A 3lk0D-4gmjB:
undetectable		 3lk0D-4gmjB:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 8 TYR B 164
LEU B  72
ALA B 109
SER B 112
 None
 1.08A 3rodA-4gmjB:
undetectable		 3rodA-4gmjB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 5 ASP B  70
LEU B 174
ILE B  74
PHE B  43
 None
None
CL  B 304 (-4.3A)
GOL  B 303 (-2.9A)
 1.23A 3s3vA-4gmjB:
undetectable		 3s3vA-4gmjB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 5 LEU B  77
GLY B  78
PHE B  97
PHE B 136
 None
 1.09A 3smtA-4gmjB:
undetectable		 3smtA-4gmjB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 10 PHE B 188
PHE B 189
ALA B 137
THR B 133
ILE B  74
 None
None
None
CL  B 304 ( 4.7A)
CL  B 304 (-4.3A)
 1.38A 3t3qA-4gmjB:
undetectable		 3t3qA-4gmjB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 10 PHE B 188
PHE B 189
ALA B 137
THR B 133
ILE B  74
 None
None
None
CL  B 304 ( 4.7A)
CL  B 304 (-4.3A)
 1.40A 3t3qB-4gmjB:
undetectable		 3t3qB-4gmjB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 10 PHE B 188
PHE B 189
ALA B 137
THR B 133
ILE B  74
 None
None
None
CL  B 304 ( 4.7A)
CL  B 304 (-4.3A)
 1.40A 3t3qC-4gmjB:
undetectable		 3t3qC-4gmjB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 10 PHE B 188
PHE B 189
ALA B 137
THR B 133
ILE B  74
 None
None
None
CL  B 304 ( 4.7A)
CL  B 304 (-4.3A)
 1.40A 3t3qD-4gmjB:
undetectable		 3t3qD-4gmjB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		5 / 12 ILE A1173
LEU A1222
ILE A1210
VAL A1265
LEU A1266
 None
 0.76A 3w67B-4gmjA:
undetectable		 3w67B-4gmjA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens) 		4 / 5 THR A1178
LEU A1316
GLU A1223
LYS A1227
 None
 1.19A 4a3pA-4gmjA:
undetectable		 4a3pA-4gmjA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 5 HIS B 258
GLY B 257
TYR B 255
TYR B 193
 None
 1.48A 4ae1B-4gmjB:
undetectable		 4ae1B-4gmjB:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		5 / 12 GLY B 159
HIS B 157
ASP B 194
ILE B 166
LEU B  65
 None
 1.23A 4pooA-4gmjB:
undetectable		 4pooA-4gmjB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 6 ASP B  70
LEU B  65
ILE B 184
PHE B 181
 None
 0.95A 4y4dA-4gmjB:
undetectable		 4y4dA-4gmjB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4gmj CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
(Homo
sapiens) 		4 / 4 TYR B  88
GLY B 228
SER B 231
LEU B 232
 None
 1.41A 5bphC-4gmjB:
undetectable		 5bphC-4gmjB:
22.22