SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gn1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 297
VAL A 296
MET A 277
VAL A 275
ILE A 273
 None
 1.17A 2uxoB-4gn1A:
undetectable		 2uxoB-4gn1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL A 275
LEU A 333
VAL A 287
VAL A 296
LEU A 314
 None
 1.00A 3gwxA-4gn1A:
undetectable		 3gwxA-4gn1A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASN A 339
ASN A 449
GLU A 331
 MLI  A 601 (-3.7A)
MLI  A 601 (-4.0A)
None
 0.85A 3kpdC-4gn1A:
undetectable		 3kpdC-4gn1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASN A 339
ASN A 449
GLU A 331
 MLI  A 601 (-3.7A)
MLI  A 601 (-4.0A)
None
 0.91A 3kpdB-4gn1A:
undetectable		 3kpdB-4gn1A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ASN A 336
GLU A 316
GLU A 331
GLU A 328
 MLI  A 601 (-3.6A)
MLI  A 601 (-2.7A)
None
None
 1.34A 4mi4A-4gn1A:
undetectable		 4mi4A-4gn1A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PHE A 327
THR A 292
GLU A 328
ASN A 498
 MLI  A 601 (-4.8A)
None
None
None
 1.24A 5ybbA-4gn1A:
undetectable		 5ybbA-4gn1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 509
TYR A 505
GLU A 331
ASN A 449
 None
None
None
MLI  A 601 (-4.0A)
 1.09A 6c71B-4gn1A:
undetectable		 6c71B-4gn1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 501
LEU A 297
TYR A 357
VAL A 293
 None
 1.29A 6g2pA-4gn1A:
undetectable		 6g2pA-4gn1A:
19.39