SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gn8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 6 THR A  44
LEU A  29
LYS A 283
TYR A 259
 None
 1.16A 1gtiC-4gn8A:
undetectable		 1gtiC-4gn8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 HIS A 162
TYR A 180
LEU A 160
LEU A 182
 None
 1.07A 1i7zA-4gn8A:
undetectable		 1i7zA-4gn8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 6 SER A 170
ILE A 202
ALA A 125
ALA A 119
 None
None
ASO  A 305 (-4.6A)
None
 0.80A 1w0gA-4gn8A:
undetectable		 1w0gA-4gn8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4gn8 REGUCALCIN
(Mus
musculus) 		5 / 12 GLY A 271
LEU A 272
GLY A 279
ALA A 263
ASP A 243
 None
 0.86A 2bm9F-4gn8A:
undetectable		 2bm9F-4gn8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 SER A  26
SER A  28
LEU A  30
ASP A  43
 None
 0.81A 2j2pA-4gn8A:
undetectable
2j2pB-4gn8A:
undetectable		 2j2pA-4gn8A:
23.21
2j2pB-4gn8A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4gn8 REGUCALCIN
(Mus
musculus) 		5 / 10 PHE A 114
GLY A 116
PHE A 178
TYR A 167
PHE A 165
 None
 1.37A 3r6wA-4gn8A:
undetectable
3r6wB-4gn8A:
undetectable		 3r6wA-4gn8A:
23.08
3r6wB-4gn8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 7 ARG A 101
LEU A 171
ASN A 154
TYR A 167
 ASO  A 305 (-3.0A)
None
CA  A 301 ( 2.4A)
None
 1.28A 4f8yC-4gn8A:
undetectable
4f8yD-4gn8A:
undetectable		 4f8yC-4gn8A:
19.40
4f8yD-4gn8A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 4gn8 REGUCALCIN
(Mus
musculus) 		3 / 3 ASP A 151
ARG A 129
ASP A 148
 None
 0.77A 4fp9A-4gn8A:
undetectable		 4fp9A-4gn8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 5 PRO A 229
ASP A 228
ILE A 208
VAL A 289
 ASO  A 304 (-4.4A)
None
None
None
 1.40A 4hytA-4gn8A:
undetectable		 4hytA-4gn8A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 ASN A 103
MET A 118
GLU A 121
GLU A 120
 ASO  A 305 ( 3.0A)
ASO  A 305 ( 4.4A)
ASO  A 305 (-2.4A)
None
 1.07A 4mj8A-4gn8A:
undetectable
4mj8C-4gn8A:
undetectable		 4mj8A-4gn8A:
20.60
4mj8C-4gn8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 ASN A 103
MET A 118
GLU A 121
GLU A 120
 ASO  A 305 ( 3.0A)
ASO  A 305 ( 4.4A)
ASO  A 305 (-2.4A)
None
 1.14A 4mj8B-4gn8A:
undetectable
4mj8C-4gn8A:
undetectable		 4mj8B-4gn8A:
20.60
4mj8C-4gn8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 5 GLY A 155
TYR A 173
SER A 170
ASP A 204
 None
None
None
CA  A 301 ( 2.7A)
 1.35A 4xueA-4gn8A:
undetectable		 4xueA-4gn8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4gn8 REGUCALCIN
(Mus
musculus) 		3 / 3 LYS A 163
ASP A 179
ILE A 208
 None
 0.85A 5kc4E-4gn8A:
undetectable		 5kc4E-4gn8A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 ARG A 264
PRO A  35
GLY A  17
ASP A  33
 None
 1.14A 5kf8A-4gn8A:
undetectable		 5kf8A-4gn8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 ARG A 264
PRO A  35
GLY A  17
ASP A  33
 None
 1.12A 5kgpA-4gn8A:
undetectable		 5kgpA-4gn8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4gn8 REGUCALCIN
(Mus
musculus) 		4 / 8 ARG A 264
PRO A  35
GLY A  17
ASP A  33
 None
 1.12A 5kgpB-4gn8A:
undetectable		 5kgpB-4gn8A:
21.33