SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gnj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gnj TRIOSEPHOSPHATE
ISOMERASE
(Leishmania
sp.
'siamensis') 		3 / 3 GLN A  53
ILE A 247
HIS A  32
 None
 0.62A 1fm9A-4gnjA:
undetectable		 1fm9A-4gnjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gnj TRIOSEPHOSPHATE
ISOMERASE
(Leishmania
sp.
'siamensis') 		3 / 3 GLN A  53
ILE A 247
HIS A  32
 None
 0.60A 1k74A-4gnjA:
undetectable		 1k74A-4gnjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4gnj TRIOSEPHOSPHATE
ISOMERASE
(Leishmania
sp.
'siamensis') 		5 / 10 GLY A 212
VAL A 215
ALA A 184
ASN A 219
ILE A 229
 None
 1.07A 1likA-4gnjA:
undetectable		 1likA-4gnjA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4gnj TRIOSEPHOSPHATE
ISOMERASE
(Leishmania
sp.
'siamensis') 		4 / 5 LEU A 210
LEU A 207
MET A 123
THR A 250
 None
 1.38A 2oaxD-4gnjA:
undetectable		 2oaxD-4gnjA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4gnj TRIOSEPHOSPHATE
ISOMERASE
(Leishmania
sp.
'siamensis') 		4 / 4 ASN A  12
SER A  45
ALA A  43
VAL A  42
 None
 1.28A 4x1kC-4gnjA:
undetectable		 4x1kC-4gnjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4gnj TRIOSEPHOSPHATE
ISOMERASE
(Leishmania
sp.
'siamensis') 		4 / 6 ILE A  22
VAL A  42
VAL A  52
TRP A  13
 None
 0.93A 5jwaH-4gnjA:
undetectable		 5jwaH-4gnjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4gnj TRIOSEPHOSPHATE
ISOMERASE
(Leishmania
sp.
'siamensis') 		4 / 4 ASN A  12
SER A  45
ALA A  43
VAL A  42
 None
 1.39A 5nm5A-4gnjA:
undetectable		 5nm5A-4gnjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4gnj TRIOSEPHOSPHATE
ISOMERASE
(Leishmania
sp.
'siamensis') 		3 / 3 GLN A  53
ILE A 247
HIS A  32
 None
 0.53A 5z12B-4gnjA:
undetectable		 5z12B-4gnjA:
14.50