SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ALA A 273
ARG A 250
ILE A 233
ILE A 245
THR A 274
 None
 1.04A 1d1gA-4gnrA:
undetectable		 1d1gA-4gnrA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ALA A 273
ARG A 250
ILE A 233
ILE A 245
THR A 274
 None
 1.04A 1d1gB-4gnrA:
undetectable		 1d1gB-4gnrA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 GLY A 266
ASN A 265
SER A 137
GLY A 263
VAL A 270
 None
None
None
ILE  A 401 (-3.6A)
None
 1.23A 1ffyA-4gnrA:
undetectable		 1ffyA-4gnrA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ASN A  46
ASP A 159
ILE A 193
ASP A 262
ALA A 122
 None
None
None
ILE  A 401 (-2.8A)
None
 1.34A 2qmjA-4gnrA:
2.9		 2qmjA-4gnrA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 10 ALA A 273
ILE A 281
ILE A 233
ILE A 245
THR A 274
 None
 1.09A 3clbD-4gnrA:
2.3		 3clbD-4gnrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 LEU A 135
ALA A 111
GLY A 132
ILE A 136
LEU A 343
 None
 1.34A 3gyqA-4gnrA:
3.6
3gyqB-4gnrA:
undetectable		 3gyqA-4gnrA:
23.51
3gyqB-4gnrA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 10 ALA A 273
ILE A 281
ILE A 233
ILE A 245
THR A 274
 None
 1.10A 3hbbD-4gnrA:
undetectable		 3hbbD-4gnrA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 5 VAL A 133
PHE A 153
ILE A 136
PHE A 358
 None
 1.06A 3owxB-4gnrA:
2.6		 3owxB-4gnrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 5 GLY A 237
ASP A 184
GLN A 248
MET A 252
 None
None
CL  A 405 (-4.1A)
None
 1.35A 3qx3A-4gnrA:
undetectable		 3qx3A-4gnrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 5 GLY A 237
ASP A 184
GLN A 248
MET A 252
 None
None
CL  A 405 (-4.1A)
None
 1.32A 3qx3B-4gnrA:
undetectable		 3qx3B-4gnrA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 7 ARG A 250
ALA A 278
ILE A 281
GLY A 243
 None
 0.95A 3v4tH-4gnrA:
undetectable		 3v4tH-4gnrA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 4 ASN A 265
SER A  91
LEU A  53
THR A 314
 None
 1.38A 4an2A-4gnrA:
undetectable		 4an2A-4gnrA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		3 / 3 GLN A  81
ASP A  69
GLN A  65
 None
 0.78A 4aztA-4gnrA:
2.0		 4aztA-4gnrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 SER A 187
GLN A 162
PHE A 157
ILE A 154
 None
 0.84A 4dx7B-4gnrA:
undetectable		 4dx7B-4gnrA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 LEU A 145
ILE A 154
ALA A 124
GLY A  57
ALA A 140
 None
None
None
None
ILE  A 401 (-4.1A)
 0.94A 4enhA-4gnrA:
undetectable		 4enhA-4gnrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 ASP A 159
ASP A 143
GLU A  48
ASP A 262
 None
None
None
ILE  A 401 (-2.8A)
 1.07A 4feuD-4gnrA:
undetectable		 4feuD-4gnrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 ALA A 120
TYR A 189
ILE A 193
TYR A 238
GLY A 260
 None
ILE  A 401 (-4.0A)
None
ILE  A 401 (-4.6A)
None
 1.34A 4l9qA-4gnrA:
undetectable		 4l9qA-4gnrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 GLU A  49
ALA A  64
GLY A  63
LEU A  66
TYR A 304
 None
 1.11A 4oadA-4gnrA:
undetectable		 4oadA-4gnrA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 VAL A 246
ASP A 262
ILE A 281
VAL A 170
ILE A 166
 None
ILE  A 401 (-2.8A)
None
None
None
 0.99A 4q5mA-4gnrA:
undetectable		 4q5mA-4gnrA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 PHE A 211
ILE A 245
GLY A 260
ILE A 281
 None
 0.79A 4qogA-4gnrA:
2.6
4qogB-4gnrA:
2.5		 4qogA-4gnrA:
19.17
4qogB-4gnrA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 12 GLY A  57
ALA A  59
PHE A  45
ALA A  64
VAL A 323
 None
 1.47A 4ryaA-4gnrA:
2.9		 4ryaA-4gnrA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 9 ALA A  55
ALA A  59
SER A 313
ALA A 116
SER A 139
 None
None
None
ILE  A 401 (-4.2A)
ILE  A 401 (-3.8A)
 1.13A 4twdA-4gnrA:
undetectable
4twdB-4gnrA:
undetectable
4twdC-4gnrA:
undetectable
4twdD-4gnrA:
undetectable
4twdE-4gnrA:
undetectable		 4twdA-4gnrA:
21.62
4twdB-4gnrA:
21.62
4twdC-4gnrA:
21.62
4twdD-4gnrA:
21.62
4twdE-4gnrA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 9 ALA A  59
SER A 313
ALA A 116
SER A 139
ALA A  55
 None
None
ILE  A 401 (-4.2A)
ILE  A 401 (-3.8A)
None
 1.21A 4twdA-4gnrA:
undetectable
4twdB-4gnrA:
undetectable
4twdC-4gnrA:
undetectable
4twdD-4gnrA:
undetectable
4twdE-4gnrA:
undetectable		 4twdA-4gnrA:
21.62
4twdB-4gnrA:
21.62
4twdC-4gnrA:
21.62
4twdD-4gnrA:
21.62
4twdE-4gnrA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		5 / 6 SER A  91
GLU A  92
GLY A 263
ASP A 262
GLY A 237
 None
None
ILE  A 401 (-3.6A)
ILE  A 401 (-2.8A)
None
 1.37A 5cdnA-4gnrA:
undetectable
5cdnB-4gnrA:
2.5		 5cdnA-4gnrA:
19.65
5cdnB-4gnrA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 7 THR A 141
ASP A 159
TYR A 238
GLY A 237
 ILE  A 401 (-2.8A)
None
ILE  A 401 (-4.6A)
None
 1.07A 5hwaA-4gnrA:
undetectable		 5hwaA-4gnrA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 8 PRO A 138
ALA A 120
THR A 117
ALA A  59
 None
None
ILE  A 401 (-4.1A)
None
 0.99A 5x2tI-4gnrA:
undetectable
5x2tJ-4gnrA:
undetectable
5x2tK-4gnrA:
undetectable
5x2tL-4gnrA:
undetectable		 5x2tI-4gnrA:
17.73
5x2tJ-4gnrA:
18.58
5x2tK-4gnrA:
17.73
5x2tL-4gnrA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		4 / 6 GLU A  48
LYS A  90
GLU A  95
ALA A  96
 None
 0.83A 6an0A-4gnrA:
4.4		 6an0A-4gnrA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT
(Streptococcus
pneumoniae) 		3 / 3 LYS A 202
SER A 167
SER A 200
 None
 1.01A 6gbfA-4gnrA:
4.2		 6gbfA-4gnrA:
24.45