SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 5 GLY C 187
ILE C 185
TRP C 195
VAL C 260
 None
 1.12A 1rs7A-4gnxC:
undetectable		 1rs7A-4gnxC:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 6 VAL C 201
THR C 202
GLU C 230
LEU C 224
 None
 0.96A 1s8fB-4gnxC:
undetectable		 1s8fB-4gnxC:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		5 / 11 VAL B  98
VAL B 107
GLU A   2
LEU B  57
ILE B  56
 None
 1.44A 1t6zB-4gnxB:
undetectable		 1t6zB-4gnxB:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		5 / 12 PHE A  74
GLY A  25
VAL A  96
LEU A  93
LEU A  13
 None
 1.21A 1ya4B-4gnxA:
undetectable		 1ya4B-4gnxA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis;
Ustilago
maydis) 		3 / 3 THR B 102
THR A   5
PRO A   4
 None
 0.82A 209dC-4gnxB:
undetectable		 209dC-4gnxB:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis;
Ustilago
maydis) 		4 / 7 VAL A  99
SER A 103
ARG B 163
HIS B 162
 None
 1.11A 2f78A-4gnxA:
undetectable		 2f78A-4gnxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis;
Ustilago
maydis) 		4 / 7 VAL A  99
SER A 103
ARG B 163
HIS B 162
 None
 1.02A 2f78B-4gnxA:
undetectable		 2f78B-4gnxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis;
Ustilago
maydis) 		4 / 6 VAL A  99
SER A 103
ARG B 163
HIS B 162
 None
 1.10A 2f8dA-4gnxA:
undetectable		 2f8dA-4gnxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 6 LEU C 485
VAL C 473
VAL C 477
ILE C 600
 None
 0.89A 2hyyA-4gnxC:
undetectable		 2hyyA-4gnxC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 6 LEU C 485
VAL C 473
VAL C 477
ILE C 600
 None
 0.89A 2hyyB-4gnxC:
undetectable		 2hyyB-4gnxC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		3 / 3 LYS C 467
TYR C 470
PRO C 468
 None
 1.10A 2j9cC-4gnxC:
undetectable		 2j9cC-4gnxC:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_L_CSCL1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 4 THR C 357
LEU C 356
MET C 395
MET C 448
 None
 1.26A 2vavL-4gnxC:
0.0		 2vavL-4gnxC:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 7 ILE C 549
LEU C 548
VAL C 477
ARG C 573
 None
 0.64A 2wd9A-4gnxC:
undetectable		 2wd9A-4gnxC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 8 ILE C 549
LEU C 548
VAL C 477
ARG C 573
 None
 0.59A 2wd9B-4gnxC:
undetectable		 2wd9B-4gnxC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 6 ARG C 577
VAL C 477
ILE C 480
TYR C 579
 None
 1.19A 2yfbB-4gnxC:
undetectable		 2yfbB-4gnxC:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		3 / 3 THR A  39
SER A  40
PHE A  82
 None
 0.74A 3d4sA-4gnxA:
undetectable		 3d4sA-4gnxA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		5 / 12 VAL B  94
GLN B 109
VAL B 107
VAL B  84
VAL B 130
 None
 1.07A 3iw1A-4gnxB:
undetectable		 3iw1A-4gnxB:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 6 LEU C 485
VAL C 473
VAL C 477
ILE C 600
 None
 0.92A 3k5vA-4gnxC:
undetectable		 3k5vA-4gnxC:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 6 LEU C 485
VAL C 473
VAL C 477
ILE C 600
 None
 0.93A 3k5vB-4gnxC:
undetectable		 3k5vB-4gnxC:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		5 / 11 ILE C 255
THR C 282
ILE C 231
ASN C 261
ILE C 276
 None
 1.12A 3kpcA-4gnxC:
undetectable		 3kpcA-4gnxC:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		5 / 12 ILE C 255
THR C 282
ILE C 231
ASN C 261
ILE C 276
 None
 1.18A 3kpdB-4gnxC:
undetectable		 3kpdB-4gnxC:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 7 ILE B 154
GLU B 158
HIS B 149
VAL B 107
 None
 0.94A 4a97A-4gnxB:
undetectable		 4a97A-4gnxB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 7 ILE B 154
GLU B 158
HIS B 149
VAL B 107
 None
 0.89A 4a97D-4gnxB:
undetectable		 4a97D-4gnxB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 7 ILE B 154
GLU B 158
HIS B 149
VAL B 107
 None
 0.89A 4a97H-4gnxB:
undetectable		 4a97H-4gnxB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 7 ILE C 303
ARG C 302
VAL C 385
MET C 395
 None
 1.43A 4f4dA-4gnxC:
undetectable		 4f4dA-4gnxC:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		3 / 3 CYH C 509
ASN C 500
LYS C 497
 ZN  C 701 (-2.3A)
None
None
 1.42A 4k50A-4gnxC:
undetectable		 4k50A-4gnxC:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		5 / 12 THR B  52
ALA B 166
GLU B 165
LEU B  48
LEU B  70
 None
 1.24A 4xi3D-4gnxB:
undetectable		 4xi3D-4gnxB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 5 TYR C 274
GLU C 186
GLY C 187
SER C 189
 None
 1.48A 5jhdJ-4gnxC:
undetectable		 5jhdJ-4gnxC:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 5 ILE C 600
LYS C 481
ILE C 480
VAL C 477
 None
 0.93A 5jmnA-4gnxC:
undetectable		 5jmnA-4gnxC:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		5 / 12 MET C 401
VAL C 377
SER C 392
VAL C 317
LEU C 306
 None
 1.29A 5ubbA-4gnxC:
undetectable		 5ubbA-4gnxC:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis;
Ustilago
maydis) 		4 / 6 ARG B 163
VAL B 167
LEU B 164
ARG C 620
 None
 0.90A 5x7zA-4gnxB:
undetectable		 5x7zA-4gnxB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 8 ILE C 318
ARG C 302
ASN C 404
TYR C 417
 None
 1.22A 6hisA-4gnxC:
undetectable
6hisB-4gnxC:
undetectable		 6hisA-4gnxC:
13.14
6hisB-4gnxC:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 8 ILE C 318
ARG C 302
ASN C 404
TYR C 417
 None
 1.22A 6hisB-4gnxC:
undetectable
6hisC-4gnxC:
undetectable		 6hisB-4gnxC:
13.14
6hisC-4gnxC:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 8 ILE C 318
ARG C 302
ASN C 404
TYR C 417
 None
 1.21A 6hisC-4gnxC:
undetectable
6hisD-4gnxC:
undetectable		 6hisC-4gnxC:
13.14
6hisD-4gnxC:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 8 ILE C 318
ARG C 302
ASN C 404
TYR C 417
 None
 1.21A 6hisD-4gnxC:
undetectable
6hisE-4gnxC:
undetectable		 6hisD-4gnxC:
13.14
6hisE-4gnxC:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4gnx PUTATIVE
UNCHARACTERIZED
PROTEIN
(Ustilago
maydis) 		4 / 8 ASN C 404
TYR C 417
ILE C 318
ARG C 302
 None
 1.22A 6hisA-4gnxC:
undetectable
6hisE-4gnxC:
undetectable		 6hisA-4gnxC:
13.14
6hisE-4gnxC:
13.14