SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4go4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 11 TYR A   6
PHE A  11
PHE A 109
LEU A  71
VAL A 191
 None
 1.33A 1q23G-4go4A:
undetectable		 1q23G-4go4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 11 TYR A   6
PHE A  11
PHE A 109
LEU A  71
VAL A 191
 None
 1.38A 1q23I-4go4A:
undetectable		 1q23I-4go4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 11 TYR A   6
PHE A  11
PHE A 109
LEU A  71
VAL A 191
 None
 1.40A 1q23L-4go4A:
undetectable		 1q23L-4go4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 10 LEU A 333
ALA A 359
ALA A 352
VAL A 332
LEU A 323
 None
 1.25A 1rlbE-4go4A:
undetectable		 1rlbE-4go4A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 LEU A  68
ALA A 164
LEU A 163
ASN A 167
ALA A 463
 None
 1.17A 1sa1A-4go4A:
undetectable
1sa1B-4go4A:
undetectable		 1sa1A-4go4A:
22.98
1sa1B-4go4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 LEU A  68
ALA A 164
LEU A 163
ASN A 167
ALA A 463
 None
 1.19A 1sa1C-4go4A:
undetectable
1sa1D-4go4A:
undetectable		 1sa1C-4go4A:
22.98
1sa1D-4go4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 10 LEU A 289
GLY A 252
GLY A 284
ILE A 273
VAL A 256
 None
 0.93A 1sdtA-4go4A:
undetectable		 1sdtA-4go4A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA202_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 10 MET A   1
GLN A   2
GLU A  81
GLU A 190
GLU A 186
 None
 1.29A 1wrkA-4go4A:
undetectable
1wrkB-4go4A:
undetectable		 1wrkA-4go4A:
10.02
1wrkB-4go4A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 5 ILE A  20
LEU A   5
ALA A  37
GLU A  38
 None
 1.25A 1xvaA-4go4A:
4.5
1xvaB-4go4A:
3.4		 1xvaA-4go4A:
22.43
1xvaB-4go4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 8 ARG A 104
SER A 445
PHE A 447
LEU A 409
 None
None
NAD  A 601 (-4.5A)
NAD  A 601 (-4.3A)
 0.94A 2bfpA-4go4A:
3.4		 2bfpA-4go4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 GLY A 249
GLY A 454
ASN A 276
PRO A 147
PHE A 154
 NAD  A 601 (-3.5A)
None
None
NAD  A 601 ( 4.0A)
NAD  A 601 (-4.5A)
 1.09A 2y7hB-4go4A:
undetectable		 2y7hB-4go4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 5 ILE A 171
ARG A 183
MET A 188
THR A 189
 None
 1.34A 3abkN-4go4A:
undetectable
3abkW-4go4A:
undetectable		 3abkN-4go4A:
22.22
3abkW-4go4A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 7 TRP A 148
GLU A 175
SER A 174
ARG A 331
 NAD  A 601 (-4.0A)
NAD  A 601 (-3.7A)
NAD  A 601 (-3.8A)
None
 1.47A 3dqtA-4go4A:
undetectable
3dqtB-4go4A:
undetectable		 3dqtA-4go4A:
20.58
3dqtB-4go4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 ALA A 348
PHE A 301
ARG A 300
LEU A 298
LEU A 289
 None
 1.04A 3k2hB-4go4A:
undetectable		 3k2hB-4go4A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 8 GLY A 448
MET A 459
LEU A 409
ILE A 282
 None
None
NAD  A 601 (-4.3A)
None
 0.83A 3nbqB-4go4A:
undetectable		 3nbqB-4go4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 8 GLY A 448
MET A 459
LEU A 409
ILE A 282
 None
None
NAD  A 601 (-4.3A)
None
 0.80A 3nbqC-4go4A:
undetectable		 3nbqC-4go4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 ALA A 222
ILE A 233
LEU A 248
GLY A 225
TYR A 407
 None
None
None
NAD  A 601 (-3.5A)
None
 1.12A 3nrrA-4go4A:
undetectable		 3nrrA-4go4A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 ALA A 222
ILE A 233
LEU A 248
GLY A 225
TYR A 407
 None
None
None
NAD  A 601 (-3.5A)
None
 1.10A 3nrrB-4go4A:
2.2		 3nrrB-4go4A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 ASN A 149
PHE A 383
PHE A 447
PHE A 223
PHE A 154
 NAD  A 601 (-3.3A)
NAD  A 601 (-3.7A)
NAD  A 601 (-4.5A)
NAD  A 601 (-4.8A)
NAD  A 601 (-4.5A)
 1.48A 3nuvA-4go4A:
undetectable		 3nuvA-4go4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 LEU A  59
GLY A  65
ALA A 116
ILE A 119
GLY A 160
 None
 1.07A 3ogqB-4go4A:
undetectable		 3ogqB-4go4A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 5 ASN A 240
GLU A 458
THR A 224
SER A 239
 None
None
NAD  A 601 (-4.2A)
None
 1.36A 3p2kC-4go4A:
4.5		 3p2kC-4go4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 4 LEU A 248
GLY A 249
GLY A 225
THR A 224
 None
NAD  A 601 (-3.5A)
NAD  A 601 (-3.5A)
NAD  A 601 (-4.2A)
 0.97A 3si7A-4go4A:
undetectable		 3si7A-4go4A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 GLY A  18
GLY A 203
ALA A  37
ALA A  39
ALA A 211
 None
 1.02A 3sudA-4go4A:
undetectable		 3sudA-4go4A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 GLY A  18
GLY A 203
ALA A  37
ALA A  39
ALA A 211
 None
 1.04A 3sudD-4go4A:
undetectable		 3sudD-4go4A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 GLY A  18
GLY A 203
ALA A  39
ALA A 211
ASP A  43
 None
 0.99A 3sueC-4go4A:
undetectable		 3sueC-4go4A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 ALA A 371
VAL A 369
ILE A 336
SER A 334
PHE A 386
 None
 1.29A 4c49A-4go4A:
undetectable		 4c49A-4go4A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 5 SER A 325
ARG A 328
LEU A 327
ASP A 330
 None
 1.43A 4ifxA-4go4A:
undetectable		 4ifxA-4go4A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 5 SER A 325
ARG A 328
LEU A 327
ASP A 330
 None
 1.39A 4ig1A-4go4A:
undetectable		 4ig1A-4go4A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 7 ALA A 270
GLU A 319
LEU A 304
TRP A 414
 None
 1.04A 4iomA-4go4A:
2.0		 4iomA-4go4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 7 TRP A 148
GLU A 175
SER A 174
ARG A 331
 NAD  A 601 (-4.0A)
NAD  A 601 (-3.7A)
NAD  A 601 (-3.8A)
None
 1.47A 4k5jA-4go4A:
undetectable
4k5jB-4go4A:
undetectable		 4k5jA-4go4A:
19.57
4k5jB-4go4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 11 GLY A 410
GLY A 250
ALA A 430
LEU A 409
HIS A 429
 None
None
None
NAD  A 601 (-4.3A)
None
 1.07A 4l8fB-4go4A:
2.2		 4l8fB-4go4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 11 GLY A 410
GLY A 250
ALA A 430
LEU A 409
GLN A 452
 None
None
None
NAD  A 601 (-4.3A)
None
 1.05A 4l8fD-4go4A:
2.4		 4l8fD-4go4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 11 GLY A 410
GLY A 250
ALA A 430
LEU A 409
HIS A 429
 None
None
None
NAD  A 601 (-4.3A)
None
 1.05A 4l8fD-4go4A:
2.4		 4l8fD-4go4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		3 / 3 GLY A 321
PRO A 322
GLN A 279
 None
 0.36A 4oltB-4go4A:
undetectable		 4oltB-4go4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		3 / 3 GLY A 321
PRO A 322
GLN A 279
 None
 0.39A 4qwpB-4go4A:
undetectable		 4qwpB-4go4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 5 ARG A 110
ARG A  66
GLY A  65
GLU A  63
 None
 1.24A 4z3oA-4go4A:
undetectable
4z3oB-4go4A:
1.8		 4z3oA-4go4A:
21.40
4z3oB-4go4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 7 ARG A 110
ALA A 106
ARG A  66
GLY A  65
GLU A  63
 None
 1.49A 5btgA-4go4A:
undetectable
5btgC-4go4A:
undetectable
5btgD-4go4A:
undetectable		 5btgA-4go4A:
22.28
5btgC-4go4A:
22.28
5btgD-4go4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 4 LEU A 399
ARG A 286
ILE A 401
ILE A 288
 None
 1.08A 5dzk2-4go4A:
undetectable
5dzkM-4go4A:
undetectable
5dzkN-4go4A:
undetectable		 5dzk2-4go4A:
2.94
5dzkM-4go4A:
17.92
5dzkN-4go4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 4 ILE A 401
ILE A 288
ARG A 286
LEU A 399
 None
 1.08A 5dzkh-4go4A:
undetectable
5dzkn-4go4A:
undetectable
5dzkv-4go4A:
undetectable		 5dzkh-4go4A:
17.92
5dzkn-4go4A:
17.92
5dzkv-4go4A:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 5 HIS A 215
VAL A 201
GLY A 209
ALA A 208
 None
None
NAD  A 601 (-3.4A)
None
 1.00A 5hwaA-4go4A:
undetectable		 5hwaA-4go4A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 12 ILE A 336
GLY A 350
GLU A 381
ALA A 371
ILE A 273
 None
None
NAD  A 601 (-2.6A)
None
None
 1.21A 5igvA-4go4A:
undetectable		 5igvA-4go4A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 9 ILE A 171
MET A 159
VAL A 200
THR A 181
ILE A 184
 None
 1.44A 5mzrD-4go4A:
undetectable		 5mzrD-4go4A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 6 SER A 174
ARG A 331
TRP A 148
GLU A 175
 NAD  A 601 (-3.8A)
None
NAD  A 601 (-4.0A)
NAD  A 601 (-3.7A)
 1.50A 5uo8A-4go4A:
undetectable
5uo8B-4go4A:
undetectable		 5uo8A-4go4A:
20.38
5uo8B-4go4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 7 TRP A 148
GLU A 175
SER A 174
ARG A 331
 NAD  A 601 (-4.0A)
NAD  A 601 (-3.7A)
NAD  A 601 (-3.8A)
None
 1.45A 5vv7A-4go4A:
undetectable
5vv7B-4go4A:
undetectable		 5vv7A-4go4A:
19.57
5vv7B-4go4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 7 TRP A 148
GLU A 175
SER A 174
ARG A 331
 NAD  A 601 (-4.0A)
NAD  A 601 (-3.7A)
NAD  A 601 (-3.8A)
None
 1.46A 5vvnA-4go4A:
undetectable
5vvnB-4go4A:
undetectable		 5vvnA-4go4A:
19.57
5vvnB-4go4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 7 SER A 174
ARG A 331
TRP A 148
GLU A 175
 NAD  A 601 (-3.8A)
None
NAD  A 601 (-4.0A)
NAD  A 601 (-3.7A)
 1.46A 6av6A-4go4A:
undetectable
6av6B-4go4A:
undetectable		 6av6A-4go4A:
10.64
6av6B-4go4A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 7 SER A 174
ARG A 331
TRP A 148
GLU A 175
 NAD  A 601 (-3.8A)
None
NAD  A 601 (-4.0A)
NAD  A 601 (-3.7A)
 1.45A 6av7A-4go4A:
undetectable
6av7B-4go4A:
undetectable		 6av7A-4go4A:
10.64
6av7B-4go4A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		5 / 9 ILE A  34
SER A 325
SER A 174
GLY A 203
THR A  32
 None
None
NAD  A 601 (-3.8A)
None
None
 1.32A 6awpA-4go4A:
undetectable		 6awpA-4go4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE
(Pseudomonas
sp.
WBC-3) 		4 / 5 GLU A 365
PRO A 366
THR A 367
MET A 320
 None
 1.46A 6fgdA-4go4A:
3.0		 6fgdA-4go4A:
24.55